DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and NTRK2

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_006171.2 Gene:NTRK2 / 4915 HGNCID:8032 Length:838 Species:Homo sapiens


Alignment Length:732 Identity:202/732 - (27%)
Similarity:313/732 - (42%) Gaps:174/732 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1041 NFIFVPNIRKSKNGSSDKSD------GAEGAALDSNAIPNGGATNPSRRRRDVALEP-------- 1091
            :.:::..::::|: |.|..|      .::...|.:..|||.|..:.:....::.:|.        
Human   155 DIMWIKTLQEAKS-SPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSC 218

  Fly  1092 -----------------------ELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSN 1133
                                   |....:||:.:.::.|  ||:........||...:::| |.|
Human   219 SVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISS--DDSGKQISCVAENLVGEDQD-SVN 280

  Fly  1134 KQFYEVFAK-----ELPPNQTHFVF---------EKLRHFTRYAIFVVACREEIPSEKLRDTSFK 1184
            ...:  ||.     |.|.:..|:..         ..|:.|...||.                :..
Human   281 LTVH--FAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAIL----------------NES 327

  Fly  1185 KSLCSDYDTVFQTTKRKKFADIVMDLKVD-LEHANNTESPVRVR----------------WTPPV 1232
            |.:|    |....|...::...   |::| ..|.||.:..:..:                | |.:
Human   328 KYIC----TKIHVTNHTEYHGC---LQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGW-PGI 384

  Fly  1233 D----PNGEIVTYE----VAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIA 1289
            |    ||...|.||    .|..:  .|.......||:.|.....|   :.:..:|:..|.| |:.
Human   385 DDGANPNYPDVIYEDYGTAANDI--GDTTNRSNEIPSTDVTDKTG---REHLSVYAVVVIA-SVV 443

  Fly  1290 GYGDFTEVEHIKVEPPPSYA-KVFFWL--------LGIGLAFLIVSLFGYVCYLHKRKVPSNDLH 1345
            |:.....:..:|:.....:. |.|.|.        .|:|.|.:|.:.......||.....||...
Human   444 GFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASPLHHISNGSNTPS 508

  Fly  1346 MN-----------TEV----NPFY---ASMQYIPDDW--EVLRENIIQLAPLGQGSFGMVYEGIL 1390
            .:           |::    ||.|   .:.|..||.:  .:.|.||:....||:|:||.|:....
Human   509 SSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAEC 573

  Fly  1391 KSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMK 1455
            .:..|.......|:||: ::|:|..|.:|..||.::......|:|:..|||..|.|.::|.|.||
Human   574 YNLCPEQDKILVAVKTL-KDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMK 637

  Fly  1456 KGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPP---TYGRIYQMAIEIADGMAYLAAKKFVH 1517
            .|||..:||||.|   |..:|       ..||  ||   |..::..:|.:||.||.|||::.|||
Human   638 HGDLNKFLRAHGP---DAVLM-------AEGN--PPTELTQSQMLHIAQQIAAGMVYLASQHFVH 690

  Fly  1518 RDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSF 1582
            ||||.|||:|.::|.||||||||:||:|.|||||.|...:||:|||||||:....:::.|||:|.
Human   691 RDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSL 755

  Fly  1583 GVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCW----HHR------- 1636
            ||||||:.|...||:..|||.:|:..:..|.|::||..||..:::||..||    |.|       
Human   756 GVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIH 820

  Fly  1637 ------SSARPSFLDII 1647
                  :.|.|.:|||:
Human   821 TLLQNLAKASPVYLDIL 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 19/101 (19%)
PTKc_InsR_like 1364..1652 CDD:173625 125/306 (41%)
NTRK2NP_006171.2 LRR_8 92..150 CDD:404697
LRR 1 92..113
LRR 2 116..137
LRRCT_2 151..195 CDD:465313 8/40 (20%)
Ig 205..283 CDD:472250 12/80 (15%)
Ig strand B 214..218 CDD:409353 0/3 (0%)
Ig strand C 227..230 CDD:409353 0/2 (0%)
Ig strand E 245..252 CDD:409353 2/6 (33%)
Ig strand F 262..268 CDD:409353 0/5 (0%)
Ig strand G 276..279 CDD:409353 1/3 (33%)
IgI_TrkB_d5 286..379 CDD:409441 17/115 (15%)
Ig strand A 286..294 CDD:409441 1/7 (14%)
Ig strand A' 295..298 CDD:409441 1/2 (50%)
Ig strand B 301..309 CDD:409441 0/7 (0%)
Ig strand C 312..319 CDD:409441 1/6 (17%)
Ig strand C' 322..325 CDD:409441 2/18 (11%)
Ig strand D 330..335 CDD:409441 2/8 (25%)
Ig strand E 341..349 CDD:409441 1/10 (10%)
Ig strand F 357..365 CDD:409441 0/7 (0%)
Ig strand G 368..376 CDD:409441 0/7 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..514 4/22 (18%)
PTKc_TrkB 548..835 CDD:270675 122/299 (41%)
Blue background indicates that the domain is not in the aligned region.

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