Protein Alignment InR and NTRK1

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_002520.2
• Gene: NTRK1 / 4914
• HGNCID: 8031
• Length: 796
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 151/453 - (33%)
• Similarity: 217/453 - (47%)
• Gaps: 66/453 - (14%)

  Fly  1219 NTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIP------------AADFNQTAGYL 1271
            |.|.|:.|.:: |||.|.           ...|.||:|...|            |..|..|  .|
Human   386 NPEDPIPVSFS-PVDTNS-----------TSGDPVEKKDETPFGVSVAVGLAVFACLFLST--LL 436

  Fly  1272 IKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHK 1336
            :.||:            .|..:...:....|..|..         |:.::...::|.|  ..|..
Human   437 LVLNK------------CGRRNKFGINRPAVLAPED---------GLAMSLHFMTLGG--SSLSP 478

  Fly  1337 RKVPSNDLHMNTEVNPFYASMQYIPDD--WEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVD 1399
            .:...:.|..:...||     ||..|.  ..:.|.:|:....||:|:||.|:.....:..|....
Human   479 TEGKGSGLQGHIIENP-----QYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDK 538

  Fly  1400 RECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLR 1464
            ...|:|.:.| |::..|.:|..||.::......|:||..|||:.|:|.|:|.|.|:.|||..:||
Human   539 MLVAVKALKE-ASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR 602

  Fly  1465 AHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAD 1529
            :|.|:.:       |...|......|...|::..:|.::|.||.|||...|||||||.|||:|..
Human   603 SHGPDAK-------LLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ 660

  Fly  1530 DLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAA 1594
            .|.||||||||:||||.|||||.|.:.:||:|||||||:....:::.|||:||||||||:.|...
Human   661 GLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGK 725

  Fly  1595 QPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE--PQCP 1655
            ||:..|||.:.:..:..|..:|||..||..::.:|:.||......|.|..|:.|.|:  .|.|
Human   726 QPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAP 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	17/89 (19%)
		PTKc_InsR_like	1364..1652	CDD:173625	117/289 (40%)
NTRK1	NP_002520.2	leucine-rich repeat	68..92	CDD:275378
		LRR 1	90..113
		LRR_8	92..150	CDD:404697
		leucine-rich repeat	93..116	CDD:275378
		LRR 2	116..137
		leucine-rich repeat	117..139	CDD:275378
		leucine-rich repeat	140..152	CDD:275378
		LRRCT_2	151..192	CDD:465313
		Ig_TrkABC_d4	195..282	CDD:409361
		Ig strand A	195..201	CDD:409361
		Ig strand B	210..219	CDD:409361
		Ig strand C	222..229	CDD:409361
		Ig strand C'	231..233	CDD:409361
		Ig strand D	236..243	CDD:409361
		Ig strand E	246..255	CDD:409361
		Ig strand F	262..269	CDD:409361
		Ig strand G	272..279	CDD:409361
		IgI_TrKABC_d5	285..379	CDD:409360
		Ig strand A	285..291	CDD:409360
		Ig strand A'	293..296	CDD:409360
		Ig strand B	299..307	CDD:409360
		Ig strand C	310..317	CDD:409360
		Ig strand C'	320..323	CDD:409360
		Ig strand D	328..334	CDD:409360
		Ig strand E	341..349	CDD:409360
		Ig strand F	357..365	CDD:409360
		Ig strand G	368..376	CDD:409360
		Interaction with SQSTM1. /evidence=ECO:0000250	469..490		4/22 (18%)
		PTKc_TrkA	504..783	CDD:270674	117/286 (41%)
		DXXLL. /evidence=ECO:0000269|PubMed:26446845	537..541		0/3 (0%)
		DXXLL. /evidence=ECO:0000269|PubMed:26446845	607..611		0/10 (0%)