Protein Alignment InR and Eph

DIOPT Version :9

• Sequence 1: NP_001138093.1
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_524625.3
• Gene: Eph / 43803
• FlyBaseID: FBgn0025936
• Length: 1096
• Species: Drosophila melanogaster
• Alignment Length: 1117
• Identity: 249/1117 - (22%)
• Similarity: 392/1117 - (35%)
• Gaps: 381/1117 - (34%)

  Fly   713 SLKFFQSLTEISGDPPMDADKYALYVL---------DNRDLD---ELWGPNQTVFIRKGGVFFHF 765
            ||.|::........||...|.|.|...         .|.|:|   |:    :::.:.|.||:|.|
  Fly   182 SLLFYEFDAATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEV----KSIAVNKKGVYFAF 242

  Fly   766 NPK-LCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKV 829
            ..: .|:|       :||.|                       |..:|..:|..|.|..|.|
  Fly   243 RDQGACIS-------VLAVK-----------------------VYYITCPAVTENFAHFNET--- 274

  Fly   830 EIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLI 894
                                           |.|.             :::..||.....:.|..
  Fly   275 -------------------------------PTGR-------------EITIIEKQNGTCVDNAE 295

  Fly   895 PYTNYSYYVRTMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVL 959
            ||...:|..:                                    .|.|    |:.|...
  Fly   296 PYETPTYLCK------------------------------------GDGK----WTILTGG---- 316

  Fly   960 TRYFIKAKLINRPTRNNNRDYCTE-PLVKAMENDLPATTP------TKKISDPLAGDCKCVEGSK 1017
                .:.|....|...|..  ||| ||......::...||      ..|...|.   |||..|
  Fly   317 ----CRCKAGYEPNYTNKT--CTECPLGTFKSPEVTKCTPCPPNSNASKTGSPF---CKCASG-- 370

  Fly  1018 KTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSR 1082
                                    |...||            ||.........|.|    ||
  Fly   371 ------------------------FYRHPN------------DGRHMPCYSPPAAP----TN--- 392

  Fly  1083 RRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFE-----KDDENTYKDEEDLSSNKQFYEVFAK 1142
                            ..||     ..|.|.|...     |::..:.:....:..:...|::...
  Fly   393 ----------------LTLL-----FVDQTSAIISWSAPAKNESFSSETNSKIYHSDIVYKIKCN 436

  Fly  1143 ELPP-----------NQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQ 1196
            ...|           |:|......|...|.|.:.:.|........:.:..|.:.||.:..|.||.
  Fly   437 ICSPNVVYNPSTDTFNETKITLTNLEPVTTYTVQIHAINSVSHINEFKRHSNESSLVAVSDIVFS 501

  Fly  1197 TTKRKKFADIVMDLKVDLEHANN-------------------------TESPVRVRWTPPVDPNG 1236
            .|.       ::::.:||.....                         |.....:.|..||..:.
  Fly   502 NTS-------LLNIPLDLNEVKTGQAEIVFTTESVLLSTVFNLRILAITNKDADLEWDKPVQSDF 559

  Fly  1237 EIVTYEVAY--KLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL-YSFRVRANSIAGYGDFTEVE 1298
            .:..|||.:  |::. |.:.:.    |.:..:|..:::.|.|.. |.|:||..:..|:|.::.:
  Fly   560 PLEFYEVRWFPKVEL-DAINKS----ALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNM- 618

  Fly  1299 HIKVEPPPSYAKVF------FWLLG---IGLAFLIVSLFGYVCYLHKR----------------- 1337
             |..:...|...|:      .::.|   .|:.||::.:...|.::..:
  Fly   619 -IYAQTLQSVGSVYDDSVQIRFIAGAIVTGVLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPL 682

  Fly  1338 -----KVPSND-------LHMNTEVNPFYASMQYI-PDDWE----VLRE-------NIIQL-APL 1377
                 :|.|.|       ||:|.....|..|..|: |..:|    .:||       |.|.: |.:
  Fly   683 DYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAII 747

  Fly  1378 GQGSFGMVYEGILKSFPPNGV-DRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVC 1441
            |.|.||.|..|.|| .|||.| |.:.||||:...::::.|.:||:|||:|.:||..:|:.|.||.
  Fly   748 GGGEFGDVCRGRLK-IPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVV 811

  Fly  1442 SRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADG 1506
            :|..|.:::.|.|:.|.|.::||.:     |....|.                ::..|...||.|
  Fly   812 TRSNPVMIITEYMENGSLDTFLRVN-----DGKFQTL----------------QLIVMLRGIASG 855

  Fly  1507 MAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD--YYRKGTKGLLPVRWMPPESLR 1569
            |:||:...:|||||||||.:|...|..||.|||::|:|....  |..:|  |.:||||..||::.
  Fly   856 MSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRG--GKIPVRWTAPEAIA 918

  Fly  1570 DGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWH 1634
            ...::|||||:|:||||||:.:...:||...||:.|::.:..|..:..|.:||:.|::||..||.
  Fly   919 FRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQ 983

  Fly  1635 HRSSARPSFLDIIAYL-----EPQ-------CPNSQFKEV--------SFYHSEAGLQHREKER- 1678
            .:.:.||:|..|::.|     :||       .|.|....:        .|..::..|:|.:..|
  Fly   984 KQRTHRPTFASIVSTLDNLARQPQSLLTTRPSPESDGNHILDGQRGQNIFISTDLWLEHIKMSRY 1048

  Fly  1679 ----KERNQLDA 1686
                ||.|.::|
  Fly  1049 CHHFKEANLINA 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382	19/80 (24%)
		FN3	1224..1302	CDD:238020	19/80 (24%)
		PTKc_InsR_like	1364..1652	CDD:173625	111/307 (36%)
		Pkinase_Tyr	1371..1650	CDD:285015	106/282 (38%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	23/111 (21%)
		FN3	387..476	CDD:238020	18/116 (16%)
		FN3	536..623	CDD:238020	20/93 (22%)
		EphA2_TM	644..736	CDD:291255	17/91 (19%)
		PTKc_EphR	736..1002	CDD:270629	108/289 (37%)
		Pkinase_Tyr	741..999	CDD:285015	106/281 (38%)
		SAM_1	1033..1092	CDD:278937	8/28 (29%)
		SAM	1039..1092	CDD:197735	7/22 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940