DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment InR and Cad96Ca

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_651349.1	Gene:	Cad96Ca / 43026	FlyBaseID:	FBgn0022800	Length:	773	Species:	Drosophila melanogaster

Alignment Length:	326	Identity:	116/326 - (35%)
Similarity:	176/326 - (53%)	Gaps:	39/326 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1362 DDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVM 1426
            |.||..|..:.....||:|:||.|:.....:...|......|:||:.|:||:.:|.:.|||..||
  Fly   461 DRWEFPRYRLKFFNILGEGAFGQVWRCEATNINGNEGITTVAVKTLKESATEVDRKDLLSELEVM 525

  Fly  1427 KEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQP 1490
            |..:.: :||.|||.|:...|..|::|.:.:|.|::|||:.|.|..             .||
  Fly   526 KSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTYLRSSRAERH-------------YGN--- 574

  Fly  1491 PTYGR--------IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYET 1547
             |:|:        :.....::|.||.||.::..:||||||||.::.||.|.|:.|||..||:..:
  Fly   575 -THGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVADFGFARDVITS 638

  Fly  1548 DYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDG 1612
            ..|.:.::|.||:|||..|||.|.::|..||::|||:::||:.||.:.||.|:|...|:|.|.||
  Fly   639 KIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGISAADVMRKVRDG 703

  Fly  1613 GVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKE 1677
            ..:|:||:|...|:.:|..||.|....||.|.:||..|:           ...|:|  :.:.|.|
  Fly   704 YRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLD-----------KLLHTE--MDYIELE 755

  Fly  1678 R 1678
            |
  Fly   756 R 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020
		PTKc_InsR_like	1364..1652	CDD:173625	110/296 (37%)
		Pkinase_Tyr	1371..1650	CDD:285015	106/287 (37%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		STYKc	470..741	CDD:214568	106/287 (37%)
		PTKc	474..742	CDD:270623	106/284 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940