Protein Alignment InR and htl

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_524394.2
• Gene: htl / 42160
• FlyBaseID: FBgn0010389
• Length: 729
• Species: Drosophila melanogaster
• Alignment Length: 377
• Identity: 132/377 - (35%)
• Similarity: 199/377 - (52%)
• Gaps: 51/377 - (13%)

  Fly  1344 LHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVN 1408
            |....|..||......:..:||:.|.:::..|.||:|:||.|....:.    |.:   .|:|.|.
  Fly   389 LQNGNEPAPFNEYEFPLDSNWELPRSHLVLGATLGEGAFGRVVMAEVN----NAI---VAVKMVK 446

  Fly  1409 ENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERD 1472
            |..||.:..:.:.|..|||....: :::.|||.||:..|..|::|....|:||.:|..:||..||
  Fly   447 EGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRD 511

  Fly  1473 EAMMTYLNRIGVTGNVQPP--------TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVAD 1529
            :.          ..:.|||        |...:.:.|.:||.||.|||:::.:||||||||.:|:|
  Fly   512 QD----------RDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSD 566

  Fly  1530 DLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAA 1594
            |..:||.|||:.|||..||||||.|.|.||::||.||||::..|.|.|||:|:|::|||:.|...
  Fly   567 DYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQ 631

  Fly  1595 QPYQG-LSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQ 1658
            |||.. :|.|::..|::.|..||:|..|...::.||::|||..:..||.|.:|:.|::..
  Fly   632 QPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDKL----- 691

  Fly  1659 FKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLR 1710
                        ||.:|      :.||...| .||......:::||.|..|:
  Fly   692 ------------LQTKE------DYLDVDIA-NLDTPPSTSDEEEDETDNLQ 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020
		PTKc_InsR_like	1364..1652	CDD:173625	116/297 (39%)
htl	NP_524394.2	Ig	101..191	CDD:472250
		Ig strand B	121..125	CDD:409353
		Ig strand C	134..138	CDD:409353
		Ig strand E	157..161	CDD:409353
		Ig strand F	171..176	CDD:409353
		Ig strand G	184..187	CDD:409353
		Ig	200..289	CDD:472250
		Ig strand B	216..220	CDD:409353
		Ig strand C	229..233	CDD:409353
		Ig strand E	255..259	CDD:409353
		Ig strand F	269..274	CDD:409353
		Ig strand G	282..285	CDD:409353
		Protein Kinases, catalytic domain	404..692	CDD:473864	116/321 (36%)