DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and Sdr

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	932	Identity:	263/932 - (28%)
Similarity:	396/932 - (42%)	Gaps:	178/932 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 SNPTMRLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFL---LIDLINDAS---PLNRSFPKLTE 384
            |:|.:..|.:...|.|::| |.::...:|:|||.:.|.:   .:|| .|.|   .|:.....:||
  Fly    29 SSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYVDL-TDVSGNYSLDSLASNVTE 91

  Fly   385 VTDYIIIYRVTGLHSLSKIFPNLSVIRGNK-LFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIE 448
            ::||:::||.|||.||..|||.|.:|||.: |||.|:||||.|.:|.:|||.:|..|..|.:|:|
  Fly    92 ISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRNLRELGLVELLRIQSGFIRVE 156

  Fly   449 KNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQ 513
            .|..||:..|:||:.::.....|...|..|..:.:|.|  |                |.|:|..:
  Fly   157 SNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQCPL--C----------------GSLSADFE 203

  Fly   514 -LHNNRRLCWNSKLCQTK--------CPEKC-RNNCIDEHTCCSQDCLGGCVIDKNGNESCISCR 568
             :.|:...|||....|.:        ||..| .|.|.....||..:|:.||.     :::|..|.
  Fly   204 FIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGCY-----SQNCSLCA 263

  Fly   569 NVSFNNICMDSCPKGYYQFDSRCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKS--EN 631
            |......|::.|...|.....||:...||..|.:......|       ||:..|| |.||.  ..
  Fly   264 NYQGRMGCVNQCVASYELNKRRCIGHRECRELGRIPLIRGY-------QCVKKCP-GNQKEILVA 320

  Fly   632 KRMCEPCPGGKCDKECSSGL-IDSLERAREFHGCTIITGTEPLTI---SIKRESGAHVMDELKYG 692
            |.:..      |..||:... :.|.........|..|.|:  |||   :||.:    ::|.|:..
  Fly   321 KGIIH------CQVECNGDFHVKSAADLEVLQDCVTINGS--LTIELTNIKEK----IVDALENA 373

  Fly   693 LAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIR 757
            ||:|.:|...|.|..:..|.||.|.|:|..|.||..:: :||||||::|..|:.:|.||..|.|:
  Fly   374 LASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVE-NKYALYVVNNYHLEHIWPPNHLVIIQ 437

  Fly   758 KGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAM 822
            :|.:|||.||:||...|:||...|.|... ...:||..:|||.|..||.||.::..:....||..
  Fly   438 RGTLFFHLNPRLCYEKIHQLQGSLKSGEN-ISVADVSPNSNGERVICGDAVRSLNPKVEDLNSTA 501

  Fly   823 LNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKVS-SPEK 884
            :.:....            :.::.....||:.:::...|..|.|. .....| .|.|.:. .|.:
  Fly   502 VRIILDY------------MDWEGMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNWLMDVVPNQ 554

  Fly   885 SGVMVLSNLIPYTNYSYYVRTMAISSELTNAE--------SDVKNFRTNPGRPSKVTEVVATAIS 941
            |...|:|.|.|||.|:|:|:|      ||..|        |.:..|:|.|.|||.|..:..::..
  Fly   555 SRRHVISGLKPYTQYAYFVKT------LTRTEYHIQIDAYSKIGYFQTLPDRPSPVLRIYGSSEI 613

  Fly   942 DSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPL 1006
            .|:|.:.|....:|.||:..||:.|:..|......:::|....|..|           |.|
  Fly   614 SSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYVNVELENA-----------KDI---- 663

  Fly  1007 AGDCKCVEGSKKTSSQEYDD----RKVQAGMEFENALQNFIFVPNIRKSKNGS------------ 1055
              ||:|.......|..:.||    .|.|  :.:|:||.|.|:|     |:|..
  Fly   664 --DCECAGVLPYYSGPQPDDEDYYNKEQ--ITYEDALPNLIYV-----SRNHDYRRKEFEKVINY 719

  Fly  1056 ----SDKSDGAEGAALDSNAIPNGGA---------------TNPSRRRRDVALEPELDDVEGSVL 1101
                |.|.|........:...|....               .|..:::||:   .:||  :....
  Fly   720 EHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRLNSEKKQRDL---QDLD--QHKYT 779

  Fly  1102 LRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFV 1166
            :||......::.|...:..|.....||.||         ..|||..|..:...:|...|.|.|.:
  Fly   780 IRHALPKCQNSHASVVQQVEEKCVAEEPLS---------GYELPGTQHFYCLSQLEPETHYRITI 835

  Fly  1167 VACREEI------PSEKLRDTS 1182
            .||.|.:      |:|.:..|:
  Fly   836 RACVEGVVNGCSTPAEAVIKTA 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	51/115 (44%)
		Furin-like	512..645	CDD:279142	36/144 (25%)
		FU	545..592	CDD:238021	12/46 (26%)
		Recep_L_domain	663..781	CDD:279382	49/120 (41%)
		FN3	1224..1302	CDD:238020
		PTKc_InsR_like	1364..1652	CDD:173625
		Pkinase_Tyr	1371..1650	CDD:285015
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	51/115 (44%)
		Furin-like	209..332	CDD:279142	37/141 (26%)
		Recep_L_domain	347..461	CDD:279382	49/120 (41%)
		FN3	491..578	CDD:214495	23/104 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470675
Domainoid	1	1.000	63	1.000	Domainoid score	I6775
eggNOG	1	0.900	-	-		E2759_KOG4258
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.700