DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and KIT

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001372213.1 Gene:KIT / 3815 HGNCID:6342 Length:977 Species:Homo sapiens


Alignment Length:1055 Identity:235/1055 - (22%)
Similarity:379/1055 - (35%) Gaps:321/1055 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   799 GNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPS--------------NATIVFKDPRA 849
            |.||:.....:.:.|..|...|:..:|:.    |||..||              ...::..||  
Human     3 GARGAWDFLCVLLLLLRVQTGSSQPSVSP----GEPSPPSIHPGKSDLIVRVGDEIRLLCTDP-- 61

  Fly   850 FIGFV--FYHMIDPYGNSTKSSDDPCDDRWKVSSPE--KSGVMVLSNLIPYTNYSY-YVRTMA-- 907
              |||  .:.::|. .|..|.::      |.....|  .:|....:|....:|..| :||..|  
Human    62 --GFVKWTFEILDE-TNENKQNE------WITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKL 117

  Fly   908 ----------------ISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPY 956
                            :...||:.|  |.|:... |...|........|.|.|..:....:.:.|
Human   118 FLVDRSLYGKEDNDTLVRCPLTDPE--VTNYSLK-GCQGKPLPKDLRFIPDPKAGIMIKSVKRAY 179

  Fly   957 --------------GVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAME--------NDLPATTPT 999
                          .||:..||   |..||.      :...|:|...:        .:...|...
Human   180 HRLCLHCSVDQEGKSVLSEKFI---LKVRPA------FKAVPVVSVSKASYLLREGEEFTVTCTI 235

  Fly  1000 KKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNG----SSDKSD 1060
            |.:|..:....| .|.|::|..||..:........:|.  |..:.:.:.|.:.:|    .::.:.
Human   236 KDVSSSVYSTWK-RENSQQTKLQEKYNSWHHGDFNYER--QATLTISSARVNDSGVFMCYANNTF 297

  Fly  1061 GAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYK 1125
            |:.........:..|          .:.:.|.::                  ...|..|.||.  
Human   298 GSANVTTTLEVVDKG----------FINIFPMIN------------------TTVFVNDGENV-- 332

  Fly  1126 DEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFT---------------RYAIFVVACREEIPS 1175
               ||...   ||.|.|   |....:::.. |.||               ||.       .|:..
Human   333 ---DLIVE---YEAFPK---PEHQQWIYMN-RTFTDKWEDYPKSENESNIRYV-------SELHL 380

  Fly  1176 EKLRDT-----SFKKSLCSDYD-------TVFQTTKRK-----------------KFADIVMD-- 1209
            .:|:.|     :|   |.|:.|       .|:..||.:                 .|.:..:|  
Human   381 TRLKGTEGGTYTF---LVSNSDVNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWY 442

  Fly  1210 -------------LKVDLEHANNTESPVRVRWTPPVDPNGEIVTY----EVAYKLQKPDQVEEKK 1257
                         |.||::..|::..|.           |::|..    ..|:|  ....||   
Human   443 FCPGTEQRCSASVLPVDVQTLNSSGPPF-----------GKLVVQSSIDSSAFK--HNGTVE--- 491

  Fly  1258 CIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFF-WLLGIGLA 1321
            |....|..:|:.|        ::|..:.|:           ..::.|...:..:.. :::..|:.
Human   492 CKAYNDVGKTSAY--------FNFAFKGNN-----------KEQIHPHTLFTPLLIGFVIVAGMM 537

  Fly  1322 FLIVSLFGYVCYLHKRKVPSNDLHMNT--EVNP---FYASMQYIPDD--WEVLRENIIQLAPLGQ 1379
            .:||.:..|. ||.|   |..::....  |:|.   .|.....:|.|  ||..|..:.....||.
Human   538 CIIVMILTYK-YLQK---PMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGA 598

  Fly  1380 GSFGMVYE----GILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLG 1439
            |:||.|.|    |::||.....|    |:|.:..:|...||...:||..|:.....: ::|.|||
Human   599 GAFGKVVEATAYGLIKSDAAMTV----AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLG 659

  Fly  1440 VCSRGQPALVVMELMKKGDLKSYLRAHR-------PEERDEAMMTYLN----------------- 1480
            .|:.|.|.||:.|....|||.::||..|       .|:..||.: |.|                 
Human   660 ACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAAL-YKNLLHSKESSCSDSTNEYM 723

  Fly  1481 --------------------RIG--VTGNVQPP---------TYGRIYQMAIEIADGMAYLAAKK 1514
                                |||  :..:|.|.         ....:...:.::|.|||:||:|.
Human   724 DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKN 788

  Fly  1515 FVHRDLAARNCMVADDLTVKIGDFGMTRDI-YETDYYRKGTKGLLPVRWMPPESLRDGVYSSASD 1578
            .:||||||||.::......||.|||:.||| .:::|..|| ...|||:||.|||:.:.||:..||
Human   789 CIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKG-NARLPVKWMAPESIFNCVYTFESD 852

  Fly  1579 VFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPS 1642
            |:|:|:.|||:.:|.:.||.|:. :.:..:.:.:|..|..||:.|..::.:|:.||......||:
Human   853 VWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPT 917

  Fly  1643 FLDIIAYLEPQCPNS 1657
            |..|:..:|.|...|
Human   918 FKQIVQLIEKQISES 932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 42/215 (20%)
FN3 1224..1302 CDD:238020 12/81 (15%)
PTKc_InsR_like 1364..1652 CDD:173625 108/349 (31%)
KITNP_001372213.1 ig 216..306 CDD:395002 14/92 (15%)
Ig strand B 229..233 CDD:409353 0/3 (0%)
Ig strand E 267..278 CDD:409353 2/12 (17%)
Ig strand F 288..293 CDD:409353 0/4 (0%)
Ig strand G 301..304 CDD:409353 0/2 (0%)
IgI_4_SCFR 312..412 CDD:409446 26/149 (17%)
Ig strand A 312..318 CDD:409446 1/15 (7%)
Ig strand A' 322..327 CDD:409446 1/4 (25%)
Ig strand B 330..340 CDD:409446 5/17 (29%)
Ig strand C 344..351 CDD:409446 1/6 (17%)
Ig strand C' 353..356 CDD:409446 1/3 (33%)
Ig strand D 359..364 CDD:409446 0/4 (0%)
Ig strand E 373..382 CDD:409446 3/15 (20%)
Ig strand F 389..397 CDD:409446 2/10 (20%)
Ig strand G 400..411 CDD:409446 1/10 (10%)
Ig 427..503 CDD:409353 16/91 (18%)
Ig strand C 438..442 CDD:409353 1/3 (33%)
Ig strand E 471..479 CDD:409353 2/7 (29%)
Ig strand F 489..494 CDD:409353 3/7 (43%)
PTKc_Kit 554..929 CDD:270682 114/380 (30%)
Important for interaction with phosphotyrosine-binding proteins 569..571 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

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