Protein Alignment InR and Epha2

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001102447.1
• Gene: Epha2 / 366492
• RGDID: 1307204
• Length: 977
• Species: Rattus norvegicus
• Alignment Length: 807
• Identity: 212/807 - (26%)
• Similarity: 336/807 - (41%)
• Gaps: 212/807 - (26%)

  Fly   930 SKVTEVVATAISDSK--INVTWSYLDK---PYGVLTRYFIKAKLINRPTRNNNRDYCT---EPLV 986
            ::..|.:|.|:||::  ..|..:.:|.   |||.      :..|:          :||   |.||
  Rat   208 ARFPETIAVAVSDAQPLATVAGTCVDHAVVPYGG------EGPLM----------HCTVDGEWLV 256

  Fly   987 KAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKS 1051
                              |: |.|.|.||.:|.                |:|.|  ...|...||
  Rat   257 ------------------PI-GQCLCQEGYEKV----------------EDACQ--ACSPGFFKS 284

  Fly  1052 KNGSS----------DKSDGAEGAALDSN--AIPNGGATNPSRRRRDVALEPELDDVEGSVLLRH 1104
            :...|          ..::||.....:..  ..|....:.|..|............:...|.||.
  Rat   285 EASESPCLQCPEHTLPSTEGATSCQCEEGYFRAPEDPLSMPCTRPPSAPHYLTAIGMGAKVELRW 349

  Fly  1105 VRSITDDT----DAFFEKDDENTYKDEEDLSS---NKQFYEVFAKELPP---NQTHFVFEKLRHF 1159
              :...||    |..:....|..:.:..:..|   :.|:.|      ||   .:|......|...
  Rat   350 --TAPQDTGGRKDIVYSVTCEQCWPESGECGSCEASVQYSE------PPQALTRTSVTVSDLEPH 406

  Fly  1160 TRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPV 1224
            ..|. |.|..|..: |:.:...||:.:..|    :.||...          ||.||..:.|.  :
  Rat   407 MNYT-FTVEARNGV-SDLVNSRSFRTASVS----INQTEPP----------KVRLEDRSTTS--L 453

  Fly  1225 RVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFN--QTAGYLIKLNEGL-----YSFR 1282
            .|.|:.||.....:..|||.|: :|.|         |..:|  :|.|:.:.| :||     |..:
  Rat   454 SVAWSIPVPQQSRVWKYEVTYR-KKGD---------ANSYNVHRTDGFSVTL-DGLAPGTTYLVQ 507

  Fly  1283 VRANSIAGYGDFTEVEHIK-VEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHKR------KVP 1340
            |:|.:..|.|..::|...: :....|........:.:|:..|:| |.|...::|:|      :..
  Rat   508 VQALTQEGQGAGSKVHEFQTLSTEGSATMAVIGGVAVGVVLLLV-LAGIGFFIHRRRRNLRARQS 571

  Fly  1341 SNDLHMN----------------------------TEVNPFYASMQYIPDDWEVLRENIIQLAPL 1377
            |.|::.:                            ||::|...|.|.:                :
  Rat   572 SEDVYFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVSRQKV----------------I 620

  Fly  1378 GQGSFGMVYEGILKSFPPNGVDRE--CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGV 1440
            |.|.||.||:|.|||   :...:|  .||||:....|:::|.:||||||:|.:|..::::||.||
  Rat   621 GAGEFGEVYKGTLKS---SSGKKEIPVAIKTLKAGYTEKQRVDFLSEASIMGQFSHHNIIRLEGV 682

  Fly  1441 CSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIAD 1505
            .|:.:|.:::.|.|:.|.|..:||     |:| ...:.|..:|               |...||.
  Rat   683 VSKYKPMMIITEYMENGALDKFLR-----EKD-GEFSVLQLVG---------------MLRGIAS 726

  Fly  1506 GMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---DIYETDYYRKGTKGLLPVRWMPPES 1567
            ||.|||...:|||||||||.:|..:|..|:.|||::|   |..|..|...|  |.:|:||..||:
  Rat   727 GMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSG--GKIPIRWTAPEA 789

  Fly  1568 LRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRC 1632
            :....::|||||:|:|:|:||:.|...:||..|||.:|::.:.||..:..|.:||..:::||.:|
  Rat   790 ISYRKFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQC 854

  Fly  1633 WHHRSSARPSFLDIIAYLEP--QCPNS 1657
            |....|.||.|.||::.|:.  :.|:|
  Rat   855 WQQERSRRPKFADIVSILDKLIRAPDS 881

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628	10/38 (26%)
		FN3	1224..1302	CDD:238020	23/85 (27%)
		PTKc_InsR_like	1364..1652	CDD:173625	108/292 (37%)
Epha2	NP_001102447.1	EphR_LBD_A2	27..200	CDD:198448
		fn3	331..419	CDD:394996	18/96 (19%)
		fn3	439..520	CDD:394996	27/103 (26%)
		EphA2_TM	<570..611	CDD:464211	4/40 (10%)
		Protein Kinases, catalytic domain	608..876	CDD:473864	112/309 (36%)
		SAM_EPH-A2	903..972	CDD:188942