DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and INSRR

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_055030.1 Gene:INSRR / 3645 HGNCID:6093 Length:1297 Species:Homo sapiens


Alignment Length:1423 Identity:511/1423 - (35%)
Similarity:720/1423 - (50%) Gaps:239/1423 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   319 SRWTRSESNPTMRLS-----QNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---L 375
            |.|......|.:.||     ..|:.|.|:|||:.|:...|||||:|:||.|.|.|:..|:.   .
Human     5 SLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFR 69

  Fly   376 NRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSI 440
            ..|||:||:||||::::||.||.||..:||||:||||.:||.|||||::....|.|:.|..|.::
Human    70 GLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAV 134

  Fly   441 TRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIE 505
            .||.||:|||.:||:..||||..:........:|..:.|  :|| ...|||.:         ...
Human   135 LRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLG--EEC-ADVCPGVL---------GAA 187

  Fly   506 GELNASCQL--HNNRRLCWNSKLCQTKCPEKCRNN--CIDEHTCCSQDCLGGCVIDKNGNESCIS 566
            ||..|....  |.:.| ||.|..||..||  |.:.  |.....||..:||||| .......:|::
Human   188 GEPCAKTTFSGHTDYR-CWTSSHCQRVCP--CPHGMACTARGECCHTECLGGC-SQPEDPRACVA 248

  Fly   567 CRNVSFNNICMDSCPKGYYQFDS-RCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSE 630
            ||::.|...|:.:||.|.||::| |||||..|.:|......:...|| :.|.|:..||:|:.::.
Human   249 CRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGI-HQGSCLAQCPSGFTRNS 312

  Fly   631 NKRMCEPCPGGKCDKECSSG--LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGL 693
            :...|..|. |.|.|||..|  .|||::.|::..|||.:.|:  |.:::::  |.::..:|::.|
Human   313 SSIFCHKCE-GLCPKECKVGTKTIDSIQAAQDLVGCTHVEGS--LILNLRQ--GYNLEPQLQHSL 372

  Fly   694 AAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDEL--W-GPNQTVF 755
            ..|..|...|.:..::.|.||.||::|..|.||..:|.: |.||||||::|.:|  | ....|:.
Human   373 GLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGN-YTLYVLDNQNLQQLGSWVAAGLTIP 436

  Fly   756 IRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANS 820
            :  |.::|.|||:||:..|.:|..:..::.: ..|:::...:||:|.:|.|..|........|:.
Human   437 V--GKIYFAFNPRLCLEHIYRLEEVTGTRGR-QNKAEINPRTNGDRAACQTRTLRFVSNVTEADR 498

  Fly   821 AMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKS-SDDPCDDR-WK----- 878
            .:|.       .|..:|..|       |..:.|:.|:...|:.|:|:. ..|.|..: |.     
Human   499 ILLR-------WERYEPLEA-------RDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVE 549

  Fly   879 --VSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTN----AESDVKNFRTNPGRPSKVTEVVA 937
              :|..::.|| .|::|.|:|.|:.:||.:.:::|..:    |:|.:...||.|..|:...:|::
Human   550 LPLSRTQEPGV-TLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQDVIS 613

  Fly   938 TAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNN---RDYCTEPLVKAMENDLPATTPT 999
            |:.|.|.:.|.|....:..|.||.|.:   |..|...:.:   .|||...|.....|:.|.    
Human   614 TSNSSSHLLVRWKPPTQRNGNLTYYLV---LWQRLAEDGDLYLNDYCHRGLRLPTSNNDPR---- 671

  Fly  1000 KKISDPLAGD---------CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVP-------NI 1048
               .|...||         |.|............:.::.....:|||.|.|.|.:|       :|
Human   672 ---FDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSI 733

  Fly  1049 RKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTD 1113
            .||....|.:...|.|               |.|                               
Human   734 NKSPQRDSGRHRRAAG---------------PLR------------------------------- 752

  Fly  1114 AFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKL 1178
                            |..|...:|:...::|..:.  |...|||||.|.|.:.||.....:.. 
Human   753 ----------------LGGNSSDFEIQEDKVPRERA--VLSGLRHFTEYRIDIHACNHAAHTVG- 798

  Fly  1179 RDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEV 1243
                     ||....||..|...:.||.:.. ||..|  .::::.|.:||..|.||||.|:.||:
Human   799 ---------CSAATFVFARTMPHREADGIPG-KVAWE--ASSKNSVLLRWLEPPDPNGLILKYEI 851

  Fly  1244 AYKLQKPDQVEEKK---CIPAADFNQTAG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEP 1304
            .|:     ::.|:.   |:....:.:..| :|..|..|.||.||||.|:||.|.:|:        
Human   852 KYR-----RLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTD-------- 903

  Fly  1305 PPSYAKVFFWLLG-----------------IGLAFLIV-SLFGYVCYLHKRKVPSNDLHMNTEVN 1351
                 .|.|::||                 :||..||| :..|:. |..||     :..:...||
Human   904 -----SVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFF-YGKKR-----NRTLYASVN 957

  Fly  1352 P--FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDR 1414
            |  |.||..|:||:|||.||.|..:..||||||||||||:.:...........|:|||||.|:.|
Human   958 PEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPR 1022

  Fly  1415 ERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYL 1479
            |...||.||||||.|..:||||||||.|:|||.||:||||.:|||||:||:.|||..:..     
Human  1023 ECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNP----- 1082

  Fly  1480 NRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDI 1544
                   .:..|..|.:.|||.|||||||||||.||||||||||||||:.|.||||||||||||:
Human  1083 -------GLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV 1140

  Fly  1545 YETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV 1609
            |||||||||.|||||||||.||||:||::::.|||:||||||||:.|||.||||||||||||::|
Human  1141 YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV 1205

  Fly  1610 IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHS 1667
            :||||:|..|.||..|.:||.|||......||||..|:..::.:...| |:.:|||:|
Human  1206 MDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPS-FRLLSFYYS 1262

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032 56/111 (50%)
Furin-like 510..645 CDD:395614 48/139 (35%)
Recep_L_domain 663..781 CDD:460032 41/120 (34%)
FN3 791..>964 CDD:442628 47/185 (25%)
FN3 1224..1302 CDD:238020 29/81 (36%)
PTKc_InsR_like 1364..1652 CDD:173625 177/287 (62%)
INSRRNP_055030.1 Recep_L_domain 47..158 CDD:460032 56/110 (51%)
Furin-like 173..326 CDD:395614 56/170 (33%)
Recep_L_domain 346..461 CDD:460032 41/121 (34%)
FN3 <489..>640 CDD:442628 41/165 (25%)
FN3 605..>649 CDD:238020 13/46 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..687 5/27 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..758 10/87 (11%)
FN3 819..908 CDD:238020 33/109 (30%)
PTKc_InsR_like 972..1248 CDD:173625 177/287 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1297
Blue background indicates that the domain is not in the aligned region.

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