DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and INSRR

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_055030.1	Gene:	INSRR / 3645	HGNCID:	6093	Length:	1297	Species:	Homo sapiens

Alignment Length:	1423	Identity:	511/1423 - (35%)
Similarity:	720/1423 - (50%)	Gaps:	239/1423 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 SRWTRSESNPTMRLS-----QNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---L 375
            |.|......|.:.||     ..|:.|.|:|||:.|:...|||||:|:||.|.|.|:..|:.   .
Human     5 SLWPWGACLPVIFLSLGFGLDTVEVCPSLDIRSEVAELRQLENCSVVEGHLQILLMFTATGEDFR 69

  Fly   376 NRSFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSI 440
            ..|||:||:||||::::||.||.||..:||||:||||.:||.|||||::....|.|:.|..|.::
Human    70 GLSFPRLTQVTDYLLLFRVYGLESLRDLFPNLAVIRGTRLFLGYALVIFEMPHLRDVALPALGAV 134

  Fly   441 TRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIE 505
            .||.||:|||.:||:..||||..:........:|..:.|  :|| ...|||.:         ...
Human   135 LRGAVRVEKNQELCHLSTIDWGLLQPAPGANHIVGNKLG--EEC-ADVCPGVL---------GAA 187

  Fly   506 GELNASCQL--HNNRRLCWNSKLCQTKCPEKCRNN--CIDEHTCCSQDCLGGCVIDKNGNESCIS 566
            ||..|....  |.:.| ||.|..||..||  |.:.  |.....||..:||||| .......:|::
Human   188 GEPCAKTTFSGHTDYR-CWTSSHCQRVCP--CPHGMACTARGECCHTECLGGC-SQPEDPRACVA 248

  Fly   567 CRNVSFNNICMDSCPKGYYQFDS-RCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSE 630
            ||::.|...|:.:||.|.||::| |||||..|.:|......:...|| :.|.|:..||:|:.::.
Human   249 CRHLYFQGACLWACPPGTYQYESWRCVTAERCASLHSVPGRASTFGI-HQGSCLAQCPSGFTRNS 312

  Fly   631 NKRMCEPCPGGKCDKECSSG--LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGL 693
            :...|..|. |.|.|||..|  .|||::.|::..|||.:.|:  |.:::::  |.::..:|::.|
Human   313 SSIFCHKCE-GLCPKECKVGTKTIDSIQAAQDLVGCTHVEGS--LILNLRQ--GYNLEPQLQHSL 372

  Fly   694 AAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDEL--W-GPNQTVF 755
            ..|..|...|.:..::.|.||.||::|..|.||..:|.: |.||||||::|.:|  | ....|:.
Human   373 GLVETITGFLKIKHSFALVSLGFFKNLKLIRGDAMVDGN-YTLYVLDNQNLQQLGSWVAAGLTIP 436

  Fly   756 IRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANS 820
            :  |.::|.|||:||:..|.:|..:..::.: ..|:::...:||:|.:|.|..|........|:.
Human   437 V--GKIYFAFNPRLCLEHIYRLEEVTGTRGR-QNKAEINPRTNGDRAACQTRTLRFVSNVTEADR 498

  Fly   821 AMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKS-SDDPCDDR-WK----- 878
            .:|.       .|..:|..|       |..:.|:.|:...|:.|:|:. ..|.|..: |.
Human   499 ILLR-------WERYEPLEA-------RDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVE 549

  Fly   879 --VSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTN----AESDVKNFRTNPGRPSKVTEVVA 937
              :|..::.|| .|::|.|:|.|:.:||.:.:::|..:    |:|.:...||.|..|:...:|::
Human   550 LPLSRTQEPGV-TLASLKPWTQYAVFVRAITLTTEEDSPHQGAQSPIVYLRTLPAAPTVPQDVIS 613

  Fly   938 TAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNN---RDYCTEPLVKAMENDLPATTPT 999
            |:.|.|.:.|.|....:..|.||.|.:   |..|...:.:   .|||...|.....|:.|.
Human   614 TSNSSSHLLVRWKPPTQRNGNLTYYLV---LWQRLAEDGDLYLNDYCHRGLRLPTSNNDPR---- 671

  Fly  1000 KKISDPLAGD---------CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVP-------NI 1048
               .|...||         |.|............:.::.....:|||.|.|.|.:|       :|
Human   672 ---FDGEDGDPEAEMESDCCPCQHPPPGQVLPPLEAQEASFQKKFENFLHNAITIPISPWKVTSI 733

  Fly  1049 RKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTD 1113
            .||....|.:...|.|               |.|
Human   734 NKSPQRDSGRHRRAAG---------------PLR------------------------------- 752

  Fly  1114 AFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKL 1178
                            |..|...:|:...::|..:.  |...|||||.|.|.:.||.....:..
Human   753 ----------------LGGNSSDFEIQEDKVPRERA--VLSGLRHFTEYRIDIHACNHAAHTVG- 798

  Fly  1179 RDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEV 1243
                     ||....||..|...:.||.:.. ||..|  .::::.|.:||..|.||||.|:.||:
Human   799 ---------CSAATFVFARTMPHREADGIPG-KVAWE--ASSKNSVLLRWLEPPDPNGLILKYEI 851

  Fly  1244 AYKLQKPDQVEEKK---CIPAADFNQTAG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEP 1304
            .|:     ::.|:.   |:....:.:..| :|..|..|.||.||||.|:||.|.:|:
Human   852 KYR-----RLGEEATVLCVSRLRYAKFGGVHLALLPPGNYSARVRATSLAGNGSWTD-------- 903

  Fly  1305 PPSYAKVFFWLLG-----------------IGLAFLIV-SLFGYVCYLHKRKVPSNDLHMNTEVN 1351
                 .|.|::||                 :||..||| :..|:. |..||     :..:...||
Human   904 -----SVAFYILGPEEEDAGGLHVLLTATPVGLTLLIVLAALGFF-YGKKR-----NRTLYASVN 957

  Fly  1352 P--FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDR 1414
            |  |.||..|:||:|||.||.|..:..||||||||||||:.:...........|:|||||.|:.|
Human   958 PEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPR 1022

  Fly  1415 ERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYL 1479
            |...||.||||||.|..:||||||||.|:|||.||:||||.:|||||:||:.|||..:..
Human  1023 ECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNP----- 1082

  Fly  1480 NRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDI 1544
                   .:..|..|.:.|||.|||||||||||.||||||||||||||:.|.||||||||||||:
Human  1083 -------GLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDV 1140

  Fly  1545 YETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV 1609
            |||||||||.|||||||||.||||:||::::.|||:||||||||:.|||.||||||||||||::|
Human  1141 YETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFV 1205

  Fly  1610 IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHS 1667
            :||||:|..|.||..|.:||.|||......||||..|:..::.:...| |:.:|||:|
Human  1206 MDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPS-FRLLSFYYS 1262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	56/111 (50%)
		Furin-like	512..645	CDD:279142	47/137 (34%)
		FU	545..592	CDD:238021	19/47 (40%)
		Recep_L_domain	663..781	CDD:279382	41/120 (34%)
		FN3	1224..1302	CDD:238020	29/81 (36%)
		PTKc_InsR_like	1364..1652	CDD:173625	177/287 (62%)
		Pkinase_Tyr	1371..1650	CDD:285015	172/278 (62%)
INSRR	NP_055030.1	Recep_L_domain	47..158	CDD:279382	56/110 (51%)
		Furin-like	173..326	CDD:279142	56/170 (33%)
		FU	228..275	CDD:238021	19/47 (40%)
		Recep_L_domain	346..460	CDD:279382	41/120 (34%)
		FN3	490..600	CDD:238020	27/124 (22%)
		FN3	605..>649	CDD:238020	13/46 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..687		5/27 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..758		10/87 (11%)
		FN3	819..908	CDD:238020	33/109 (30%)
		PTKc_InsR_like	972..1248	CDD:173625	177/287 (62%)
		Pkinase_Tyr	979..1246	CDD:285015	172/278 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1297
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	365	1.000	Domainoid score	I933
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I488
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm41905
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.840