DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and INSR

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_000199.2	Gene:	INSR / 3643	HGNCID:	6091	Length:	1382	Species:	Homo sapiens

Alignment Length:	1480	Identity:	547/1480 - (36%)
Similarity:	771/1480 - (52%)	Gaps:	221/1480 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---LNRSFPKLTEVTDYIIIYRVTGLHSL 400
            |..|||||.::..::||||:||||.|.|.|:....|   .:.|||||..:|||::::||.||.||
Human    35 CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESL 99

  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465
            ..:||||:||||::||..||||::....|.:|||:.|.:||||.||||||::|||..||||..||
Human   100 KDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRIL 164

  Fly   466 AENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTK 530
            ...|...:||.::..| ||. ..|||..:.:.....|.|.|:.         ...||....||..
Human   165 DSVEDNYIVLNKDDNE-ECG-DICPGTAKGKTNCPATVINGQF---------VERCWTHSHCQKV 218

  Fly   531 CPEKCRNN-CIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQF-DSRCVT 593
            ||..|::: |..|..||..:|||.| ...:....|::|||...:..|:::||..||.| |.|||.
Human   219 CPTICKSHGCTAEGLCCHSECLGNC-SQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN 282

  Fly   594 ANECITLTKFETNSVYSG----IPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKEC----SSG 650
            .:.|..|.....||...|    :.:|.:||..||:||..:.:..:|.||. |.|.|.|    ...
Human   283 FSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCL-GPCPKVCHLLEGEK 346

  Fly   651 LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLK 715
            .|||:..|:|..|||:|.|:  |.|:|:  .|.::..||:..|..:.:|...|.:..:|.|.||.
Human   347 TIDSVTSAQELRGCTVINGS--LIINIR--GGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS 407

  Fly   716 FFQSLTEISGDPPMDADKYALYVLDNRDLDELWG-PNQTVFIRKGGVFFHFNPKLCVSTINQLLP 779
            ||:.|..|.|: .::...|:.|.|||::|.:||. ....:.|.:|.:|||:|||||:|.|:::..
Human   408 FFRKLRLIRGE-TLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEE 471

  Fly   780 MLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVF 844
            :..:|.: .|::|:...:||::.||...:|..:......:..:|.       .||..|.:    |
Human   472 VSGTKGR-QERNDIALKTNGDQASCENELLKFSYIRTSFDKILLR-------WEPYWPPD----F 524

  Fly   845 KDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKV--------SSPEKS----GVMVLSNLIP 895
            :|   .:||:.::...||.|.|: ...|.| .:.|.|        |:..||    | .::..|.|
Human   525 RD---LLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG-WLMRGLKP 585

  Fly   896 YTNYSYYVRTMAISSE---LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYG 957
            :|.|:.:|:|:...|:   ...|:||:...:|:...||...:.::.:.|.|:|.:.|.....|.|
Human   586 WTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNG 650

  Fly   958 VLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQ 1022
            .:|.|.:..:.....:.....|||.:.|          ..|::..|.|...     |.|:|.:..
Human   651 NITHYLVFWERQAEDSELFELDYCLKGL----------KLPSRTWSPPFES-----EDSQKHNQS 700

  Fly  1023 EYDDRKVQAG----------------------MEFENALQNFIFVPNIRKSKNGSSDKSDGAEGA 1065
            ||:|   .||                      ..||:.|.|.:|||  ||:.:|:     |||.
Human   701 EYED---SAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVP--RKTSSGT-----GAED- 754

  Fly  1066 ALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDL 1130
                        ..|||:||      .|.|| |:|      ::...|.|.|......:.....:
Human   755 ------------PRPSRKRR------SLGDV-GNV------TVAVPTVAAFPNTSSTSVPTSPE- 793

  Fly  1131 SSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVF 1195
             .::.|.:|..||      ..|...|||||.|.|.:.||.::.|.|:          ||....|.
Human   794 -EHRPFEKVVNKE------SLVISGLRHFTGYRIELQACNQDTPEER----------CSVAAYVS 841

  Fly  1196 QTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIP 1260
            ..|..:..||   |:...:.|.....:.|.:.|..|.:|||.||.|||:|:....:::.  .|:.
Human   842 ARTMPEAKAD---DIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELH--LCVS 901

  Fly  1261 AADFNQTAGYLIK-LNEGLYSFRVRANSIAGYGDFTEVEHIKV----EPPPSYAKVFFWLLGIGL 1320
            ...|....|..:: |:.|.||.|:||.|:||.|.:||..:..|    :.|.:.||:.     ||
Human   902 RKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKII-----IG- 960

  Fly  1321 AFLIVSLFGYV-----CYLHKRKV--PSNDLHMNTEVNPFYASMQ-------YIPDDWEVLRENI 1371
            ..:.|.||..|     .:|.||:.  |...|:.::  ||.|.|..       |:||:|||.||.|
Human   961 PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASS--NPEYLSASDVFPCSVYVPDEWEVSREKI 1023

  Fly  1372 IQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVR 1436
            ..|..||||||||||||..:.......:...|:|||||:|:.|||..||:||||||.|..:||||
Human  1024 TLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVR 1088

  Fly  1437 LLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAI 1501
            ||||.|:|||.|||||||..||||||||:.|||..:..            ...|||...:.|||.
Human  1089 LLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNP------------GRPPPTLQEMIQMAA 1141

  Fly  1502 EIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPE 1566
            |||||||||.|||||||||||||||||.|.||||||||||||||||||||||.|||||||||.||
Human  1142 EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE 1206

  Fly  1567 SLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQR 1631
            ||:|||::::||::||||||||:.:||.||||||||||||::|:|||.:::|:|||:.:..||:.
Human  1207 SLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRM 1271

  Fly  1632 CWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKE-RNQLDAFAAVPLDQD 1695
            ||......||:||:|:..|:... :..|.||||:|||   :::..|.:| ..:.:....||||:
Human  1272 CWQFNPKMRPTFLEIVNLLKDDL-HPSFPEVSFFHSE---ENKAPESEELEMEFEDMENVPLDR- 1331

  Fly  1696 LQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSG 1745
             ....|:|:|      |.....|||        ........|:|::..:|
Human  1332 -SSHCQREEA------GGRDGGSSL--------GFKRSYEEHIPYTHMNG 1366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	60/111 (54%)
		Furin-like	512..645	CDD:279142	46/138 (33%)
		FU	545..592	CDD:238021	18/47 (38%)
		Recep_L_domain	663..781	CDD:279382	43/118 (36%)
		FN3	1224..1302	CDD:238020	28/78 (36%)
		PTKc_InsR_like	1364..1652	CDD:173625	181/287 (63%)
		Pkinase_Tyr	1371..1650	CDD:285015	175/278 (63%)
INSR	NP_000199.2	Recep_L_domain	52..164	CDD:279382	60/111 (54%)
		Furin-like	179..337	CDD:279142	55/170 (32%)
		FU	234..281	CDD:238021	18/47 (38%)
		Recep_L_domain	359..472	CDD:279382	43/117 (37%)
		FN3	622..>665	CDD:238020	10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..708		9/29 (31%)
		Insulin-binding	733..741		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..766		10/43 (23%)
		FN3	867..944	CDD:238020	28/78 (36%)
		PTKc_InsR	1016..1303	CDD:133192	184/299 (62%)
		Pkinase_Tyr	1023..1290	CDD:285015	175/278 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1382		2/7 (29%)
		PIK3R1-binding	1361..1364		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	365	1.000	Domainoid score	I933
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	809	1.000	Inparanoid score	I488
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm41905
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4609
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870