Protein Alignment InR and Ror1

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001102141.1
• Gene: Ror1 / 362550
• RGDID: 1559469
• Length: 937
• Species: Rattus norvegicus
• Alignment Length: 1087
• Identity: 269/1087 - (24%)
• Similarity: 410/1087 - (37%)
• Gaps: 288/1087 - (26%)

  Fly   880 SSPEKSGVMVLSNLIPYTNYSYYVRTMAISSEL-----TNAESDVKNFRTNPGRPSKVTEVVATA 939
            ::.:::.:.|.:.|:|.::::       .|||:     ...:..:.|..|:.|   :..|:....
  Rat    27 AAAQETELSVSAELVPTSSWN-------TSSEIDKDSYLTLDEPMNNITTSLG---QTAELHCKV 81

  Fly   940 ISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNR--DYCTEPLVKAMENDLPATTPTKKI 1002
            ..:...|:.|...|.|            ::..|.|.:.|  :|.:...::.::     ||.|
  Rat    82 SGNPPPNIRWFKNDAP------------VVQEPRRISFRATNYGSRLRIRNLD-----TTDT--- 126

  Fly  1003 SDPLAGDCKCV--EGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGA 1065
                 |..:||  .|.|..|:         .|:.|..      |.|....|. ||||:.:
  Rat   127 -----GYFQCVATSGKKVVST---------TGVLFVK------FGPPPTASP-GSSDEYE----- 165

  Fly  1066 ALDSNAIPNGGATNPSR--------RRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDEN 1122
                    ..|...|.|        ..|.|.:|.          |.....|.:...|.|.....:
  Rat   166 --------EDGFCQPYRGIACARFIGNRTVYMES----------LHMQGEIENQITAAFTMIGTS 212

  Fly  1123 TYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSL 1187
            ::     ||.....:.:      |:..|:.|.             .|.|.....|.||      |
  Rat   213 SH-----LSDKCSQFAI------PSLCHYAFP-------------YCDETSSVPKPRD------L 247

  Fly  1188 CSDYDTVFQTT---KRKKFAD----IVMDLKV-DLEHANNTESP-----VRVRWTPPVDP----- 1234
            |.|...|.:..   ....||.    |:|.||: :.|.....|||     :|: ..|..||
  Rat   248 CRDECEVLENVLCHTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRI-GIPMADPINKNH 311

  Fly  1235 ---NGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQ--------TAGYLIKLNEGLYSFRVRANSI 1288
               |...|.|.....:.|    ..::|.|   :|.        ||....:||.|....|...|..
  Rat   312 KCYNSTGVDYRGTVSVTK----SGRQCQP---WNSQYPHTHSFTALRFPELNGGHSYCRNPGNQK 369

  Fly  1289 AGYGDFTEVEHIK---VEPPPSYAK----------VFFWLLGIGLAFLIVSLFGYVCYL-HKRKV 1339
            .....||..|:.|   .:.|...:|          ::..:..:.:...|..||.::|.. :.:|.
  Rat   370 EAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAFLFFFICVCRNNQKS 434

  Fly  1340 PSNDLH--------MNTEVNPFYASMQYIPDD--WEVLRENIIQLAPLGQGSFGMVYEGILKSFP 1394
            ||..:.        .|.|::...|   |.|..  .|:....:..:..||:.:||.:|:|.|  :.
  Rat   435 PSPPVQRQPKPVRGQNVEMSMLNA---YKPKSKAKELPLSAVRFMEELGECTFGKIYKGHL--YL 494

  Fly  1395 PNGVDRE--CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKG 1457
            | |:|..  .||||:.:....::.|.|..|||:|.|....::|.|||..::.||..::.|.|.:|
  Rat   495 P-GMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQG 558

  Fly  1458 DLKSYLRAHRP-------EERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKF 1515
            ||..:|....|       .:.|..:.:.|:            :|....:||:||.||.||::..|
  Rat   559 DLHEFLIMRSPHSDVGCSSDEDGTVKSSLD------------HGDFLHIAIQIAAGMEYLSSHFF 611

  Fly  1516 VHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVF 1580
            ||:||||||.::.:.|.|||.|.|::|:||..||||..:|..||:||||||::..|.:||.||::
  Rat   612 VHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDIW 676

  Fly  1581 SFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLD 1645
            ||||||||:.:...|||.|.||::|:..|....::...|:||..::.||..||:...|.||.|.|
  Rat   677 SFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKD 741

  Fly  1646 IIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLR 1710
            |...|               .|..||                            .....:|||..
  Rat   742 IHVRL---------------RSWEGL----------------------------SSHTSSTTPSG 763

  Fly  1711 MGDYQQNSSLDQPPES-------PIAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQNIPAA 1768
            .....|.:||...|.|       |..|...||.. |....:|||..:.|..|..:......||..
  Rat   764 GNATTQTTSLSASPVSNLSNPRFPNYMFPSQGIP-PQGQIAGFIGPAIPQNQRFIPINGYPIPPG 827

  Fly  1769 QGDISATYVVPDADALDGDRGYEIYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPRKGRQ----- 1828
            .....|.:..|     .|......:.|.|| :..|:|.||||..|.::.    ||..|..
  Rat   828 YAAFPAAHYQP-----AGPPRVIQHCPPPK-SRSPSSASGSTSTGHVAS----LPSSGSNQEANV 882

  Fly  1829 PTIMSSSMPD-------DVIGGSSLQP------STASAGSSNASSHT 1862
            |.:...|:|:       .|.|..|.:|      ..:..|.||...||
  Rat   883 PLLPHMSIPNHPGGMGITVFGNKSQKPYKIDSKQPSLLGDSNIHGHT 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628	14/88 (16%)
		FN3	1224..1302	CDD:238020	22/96 (23%)
		PTKc_InsR_like	1364..1652	CDD:173625	112/296 (38%)
Ror1	NP_001102141.1	IG_like	66..148	CDD:214653	22/118 (19%)
		Ig strand B	75..79	CDD:409570	1/3 (33%)
		Ig strand C	88..92	CDD:409570	1/3 (33%)
		Ig strand E	114..118	CDD:409570	0/3 (0%)
		Ig strand F	128..133	CDD:409570	1/4 (25%)
		Ig strand G	141..144	CDD:409570	1/11 (9%)
		CRD_TK_ROR1	166..307	CDD:143576	37/181 (20%)
		KR	311..393	CDD:214527	19/88 (22%)
		PTKc_Ror1	467..749	CDD:270672	112/311 (36%)