Protein Alignment InR and dnt

DIOPT Version :9

• Sequence 1: NP_001138093.1
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001260567.1
• Gene: dnt / 35207
• FlyBaseID: FBgn0024245
• Length: 584
• Species: Drosophila melanogaster
• Alignment Length: 586
• Identity: 134/586 - (22%)
• Similarity: 234/586 - (39%)
• Gaps: 135/586 - (23%)

  Fly  1148 QTHFVFEKLRHFTRYAI-FVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLK 1211
            :.::|.|  .|...||: |:|    .:|: .::|.||.....:.....:.........:::....
  Fly    65 EVYYVRE--GHINNYALNFIV----PVPA-NVKDISFTWQSLAGRGLPYSINVVSSDQEVLPRPA 122

  Fly  1212 VDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKC--IPAADFNQTAGYLIKL 1274
            :::.|:.  |.|..::            |:.:|.           ||  :.||:.:.|....:.|
  Fly   123 INVSHSG--EIPTTIQ------------TWSIAL-----------KCSGLKAAEVDVTVSLEVVL 162

  Fly  1275 NEGLYSFR---VRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSL---FGYVCY 1333
            |..|.:..   .|...|....|..|.....|:.|.....|.  |...||..|:|.:   .|.||.
  Fly   163 NRSLNNVTHLVFRRKKICLMNDSAEDLSEDVDDPQLLETVM--LPPTGLITLVVGVSVAMGSVCL 225

  Fly  1334 L-----------HKRK---------VPSNDLHMNTE-----------------VNPFYASM---- 1357
            |           :||:         ..|:...:||.                 :.|.:.|.
  Fly   226 LLMIAYCVKGAANKRQHHQHGGQPMRTSSFQRLNTHPPCQSSMGSAAYMTPSIIAPIHGSSLPRK 290

  Fly  1358 ------QYIPDDWEVLRENIIQL----------APLGQGSFGMVYEGILKSFPPNGVDRECAIKT 1406
                  |..|::   |...|.:|          :.|.:|:||.||.|....      .::..:||
  Fly   291 VPVSVEQQHPEE---LHRRISELTVERCRVRLSSLLQEGTFGRVYRGTYND------TQDVLVKT 346

  Fly  1407 VNENATDRERTNFLSEASVMKEFDTYHVVRLLGVC--SRGQPALVVMELMKKGDLKSYLRAHRPE 1469
            |.::|:..:....|.|..::.......::.:|||.  ....|.::...|....:||.:|
  Fly   347 VAQHASQMQVLLLLQEGMLLYGASHPGILSVLGVSIEDHTTPFVLYPALNNTRNLKQFL------ 405

  Fly  1470 ERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVK 1534
             .|.|....:..|            :|..||.:::..:.:|.:...||:|:|.|||::.|.|.||
  Fly   406 -LDPACARTVTTI------------QIVMMASQLSMALDHLHSHGVVHKDIATRNCVIDDQLRVK 457

  Fly  1535 IGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQG 1599
            :.|..::||::.:||...|.....||:||..|:|:...:|.|||.::|||::||:.|.|.|||..
  Fly   458 LSDSSLSRDLFPSDYNCLGDSENRPVKWMSLEALQHKQFSEASDSWAFGVLMWELCTSAKQPYAE 522

  Fly  1600 LSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSF 1664
            :...::..|:.||..:.:|.||||.|..:|..||....:.||:|..:     ..|.:..:.:::.
  Fly   523 VDPFEMEHYLKDGYRLAQPFNCPDELFTIMAYCWALLPAERPTFAQL-----QSCLSEFYSQITR 582

  Fly  1665 Y 1665
            |
  Fly   583 Y 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020	14/82 (17%)
		PTKc_InsR_like	1364..1652	CDD:173625	83/299 (28%)
		Pkinase_Tyr	1371..1650	CDD:285015	82/290 (28%)
dnt	NP_001260567.1	WIF	46..182	CDD:128745	26/148 (18%)
		PKc_like	310..580	CDD:304357	82/299 (27%)
		Pkinase_Tyr	317..573	CDD:285015	80/285 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455354
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940