Protein Alignment InR and CG10702

DIOPT Version :9

• Sequence 1: NP_001138093.1
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001188841.1
• Gene: CG10702 / 35181
• FlyBaseID: FBgn0032752
• Length: 946
• Species: Drosophila melanogaster
• Alignment Length: 1111
• Identity: 263/1111 - (23%)
• Similarity: 436/1111 - (39%)
• Gaps: 294/1111 - (26%)

  Fly   333 SQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLN---RSFPKLTEVTDYIIIYRV 394
            |:....|.|:||||...:.:.|:||||:.|:::|.||......|   .|:|.|||:|:::|...|
  Fly    24 SKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDV 88

  Fly   395 TGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTI 459
            .||.:::::||:|:||||.:||..|||.|.:..:|..|...||.:|.||.|.|....|||....:
  Fly    89 RGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRV 153

  Fly   460 DW-LEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWN 523
            :| |..|...|..::::.:|     |....|.|                    |...:    ||:
  Fly   154 NWDLLTLTRGENNIIMVNKN-----CSTPVCSG--------------------CSSSH----CWS 189

  Fly   524 SKLCQTKCPEKCRNNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFD 588
            :..||....|...|...:.: .|.::|||||..:.:....|..||.:|.:.:|:.||||..|..:
  Fly   190 NHYCQRSINENVANPKANIN-ACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVME 253

  Fly   589 S--RCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPC-PGGKCDKECS-- 648
            :  ||.|..||:    .:...|.||    .||:..||:|| |:.|:..|..| |...|...|:
  Fly   254 NYQRCYTKAECV----LKHGYVISG----SQCVAFCPSGY-KTNNRSECVLCSPDEACISFCTPE 309

  Fly   649 ----SGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTY 709
                :..:.:|..|....||.|..|:..:||..|...     .:|.....::.:::..:.|:.:.
  Fly   310 WPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNE-----TQLYQSFTSMREVRGHVKVYRSS 369

  Fly   710 GLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTI 774
            .|:||:|.::|..:.|| |::...|:..:.||::|.|||.|::.:...:||:|.|.|.|||...:
  Fly   370 QLRSLQFLRNLERVHGD-PLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNNKLCNRRM 433

  Fly   775 NQLLPMLASKPKFFEKS---DVGADS---NGNRGSCGTAVLNVTLQSVGANSAMLN-----VTTK 828
            .:           |:.:   |...||   |.....|....|.:.:|.....|..|:     .:.|
  Fly   434 RE-----------FQNAVTHDRALDSLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQK 487

  Fly   829 VE-IGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR--WK--VSSPE---KS 885
            :| |..|..|..               .||       .....|.|...|  ||  :..|:   ::
  Fly   488 IELIHRPLLPGK---------------LYH-------EESELDAPICTRINWKRRLLFPDDLIEN 530

  Fly   886 G---VMVLSNLIPYTNYSYYVRTMA--ISSELTNAESDVKNFRTNPGRPS-KVTEVVATAISDSK 944
            |   :..|.:|.|.|.|...:||..  .:.|...|.|::...:|....|. .:.|:|..  :||.
  Fly   531 GTHYLFDLDDLQPDTRYVVLLRTFGNDEAHEAYEARSELTYVQTELDIPKPPLLELVKK--TDSS 593

  Fly   945 INVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGD 1009
            :.|..:..|....:||.:    :|.:.......|:||.:|.....:.|
  Fly   594 LTVQMASHDHVSFLLTVF----ELSDDQDYIEQRNYCHQPSYVWQDMD----------------- 637

  Fly  1010 CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPN 1074
                 |.:..:.::|||...|...:||::.    |:.::|:....:.|..:.....|
  Fly   638 -----GPRWMAYEDYDDCCAQKAEQFEDSR----FIADMREQYRCTLDDREQCRRLA-------- 685

  Fly  1075 GGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV 1139
                     ..:|:| |:|
  Fly   686 ---------HTEVSL-PQL---------------------------------------------- 694

  Fly  1140 FAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFA 1204
               .||.|.|.:..:.|..:..||:.:.||.   |..           ||.:.|::..|.....|
  Fly   695 ---RLPGNTTEYELKALHRYRLYALQLQACN---PLG-----------CSSHTTLYGRTNYTMGA 742

  Fly  1205 DIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK--CIPAADFNQT 1267
            |::..|...  |....:..: :|:..|..|||.:..|.:.::    :...:..  |:...| :|:
  Fly   743 DLLTQLYAC--HIPEMDKYI-MRFEEPKKPNGLVTNYVIHFR----NNFSQTHVGCVTRMD-HQS 799

  Fly  1268 AGYLI--KLNEGLYSFRVRANSIAG-----Y--------GDFTEVEHIK--------VEPPPSYA 1309
            |||:.  ::|.......||.:|:||     |        .|..:..|.:        :...|:.|
  Fly   800 AGYMYVKQINITFTECAVRVHSLAGDVMTPYMPISLCSDEDRLQAFHSREAKDLSPEITDLPATA 864

  Fly  1310 KVFFWLLGIGLA-FLIVSLFG------YVCYLHK--RKVPSNDLHMNTEVNPFYASMQYIP--DD 1363
            .     .|.|:: |||..|||      :|.|..:  ||:|              ...:|:|  :.
  Fly   865 S-----HGRGISIFLICFLFGCSVSLVWVLYKRRCWRKLP--------------GLRRYVPVREQ 910

  Fly  1364 WEVLRE 1369
            |  ||:
  Fly   911 W--LRD 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	46/112 (41%)
		Furin-like	512..645	CDD:279142	43/135 (32%)
		FU	545..592	CDD:238021	17/48 (35%)
		Recep_L_domain	663..781	CDD:279382	33/117 (28%)
		FN3	1224..1302	CDD:238020	21/102 (21%)
		PTKc_InsR_like	1364..1652	CDD:173625	3/6 (50%)
		Pkinase_Tyr	1371..1650	CDD:285015
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	46/111 (41%)
		Furin-like	171..297	CDD:279142	44/164 (27%)
		FU	210..258	CDD:238021	16/47 (34%)
		Recep_L_domain	328..441	CDD:279382	34/129 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I6775
eggNOG	1	0.900	-	-		E2759_KOG4258
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920