Protein Alignment InR and CG10702

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_724157.1
• Gene: CG10702 / 35181
• FlyBaseID: FBgn0032752
• Length: 946
• Species: Drosophila melanogaster
• Alignment Length: 1111
• Identity: 263/1111 - (23%)
• Similarity: 436/1111 - (39%)
• Gaps: 294/1111 - (26%)

  Fly   333 SQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLN---RSFPKLTEVTDYIIIYRV 394
            |:....|.|:||||...:.:.|:||||:.|:::|.||......|   .|:|.|||:|:::|...|
  Fly    24 SKKEHECTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDV 88

  Fly   395 TGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTI 459
            .||.:::::||:|:||||.:||..|||.|.:..:|..|...||.:|.||.|.|....|||....:
  Fly    89 RGLVNITEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRV 153

  Fly   460 DW-LEILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWN 523
            :| |..|...|..::::.:|     |....|.|                    |...:    ||:
  Fly   154 NWDLLTLTRGENNIIMVNKN-----CSTPVCSG--------------------CSSSH----CWS 189

  Fly   524 SKLCQTKCPEKCRNNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFD 588
            :..||....|...|...:.: .|.::|||||..:.:....|..||.:|.:.:|:.||||..|..:
  Fly   190 NHYCQRSINENVANPKANIN-ACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVME 253

  Fly   589 S--RCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPC-PGGKCDKECS-- 648
            :  ||.|..||:    .:...|.||    .||:..||:|| |:.|:..|..| |...|...|:
  Fly   254 NYQRCYTKAECV----LKHGYVISG----SQCVAFCPSGY-KTNNRSECVLCSPDEACISFCTPE 309

  Fly   649 ----SGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTY 709
                :..:.:|..|....||.|..|:..:||..|...     .:|.....::.:::..:.|:.:.
  Fly   310 WPGKAFTVYNLADAENLRGCQIFNGSLVITIRNKVNE-----TQLYQSFTSMREVRGHVKVYRSS 369

  Fly   710 GLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTI 774
            .|:||:|.::|..:.|| |::...|:..:.||::|.|||.|::.:...:||:|.|.|.|||...:
  Fly   370 QLRSLQFLRNLERVHGD-PLENRHYSFILYDNKELSELWTPSRQLEFMEGGMFMHRNNKLCNRRM 433

  Fly   775 NQLLPMLASKPKFFEKS---DVGADS---NGNRGSCGTAVLNVTLQSVGANSAMLN-----VTTK 828
            .:           |:.:   |...||   |.....|....|.:.:|.....|..|:     .:.|
  Fly   434 RE-----------FQNAVTHDRALDSLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQK 487

  Fly   829 VE-IGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDR--WK--VSSPE---KS 885
            :| |..|..|..               .||       .....|.|...|  ||  :..|:   ::
  Fly   488 IELIHRPLLPGK---------------LYH-------EESELDAPICTRINWKRRLLFPDDLIEN 530

  Fly   886 G---VMVLSNLIPYTNYSYYVRTMA--ISSELTNAESDVKNFRTNPGRPS-KVTEVVATAISDSK 944
            |   :..|.:|.|.|.|...:||..  .:.|...|.|::...:|....|. .:.|:|..  :||.
  Fly   531 GTHYLFDLDDLQPDTRYVVLLRTFGNDEAHEAYEARSELTYVQTELDIPKPPLLELVKK--TDSS 593

  Fly   945 INVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGD 1009
            :.|..:..|....:||.:    :|.:.......|:||.:|.....:.|
  Fly   594 LTVQMASHDHVSFLLTVF----ELSDDQDYIEQRNYCHQPSYVWQDMD----------------- 637

  Fly  1010 CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPN 1074
                 |.:..:.::|||...|...:||::.    |:.::|:....:.|..:.....|
  Fly   638 -----GPRWMAYEDYDDCCAQKAEQFEDSR----FIADMREQYRCTLDDREQCRRLA-------- 685

  Fly  1075 GGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV 1139
                     ..:|:| |:|
  Fly   686 ---------HTEVSL-PQL---------------------------------------------- 694

  Fly  1140 FAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFA 1204
               .||.|.|.:..:.|..:..||:.:.||.   |..           ||.:.|::..|.....|
  Fly   695 ---RLPGNTTEYELKALHRYRLYALQLQACN---PLG-----------CSSHTTLYGRTNYTMGA 742

  Fly  1205 DIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK--CIPAADFNQT 1267
            |::..|...  |....:..: :|:..|..|||.:..|.:.::    :...:..  |:...| :|:
  Fly   743 DLLTQLYAC--HIPEMDKYI-MRFEEPKKPNGLVTNYVIHFR----NNFSQTHVGCVTRMD-HQS 799

  Fly  1268 AGYLI--KLNEGLYSFRVRANSIAG-----Y--------GDFTEVEHIK--------VEPPPSYA 1309
            |||:.  ::|.......||.:|:||     |        .|..:..|.:        :...|:.|
  Fly   800 AGYMYVKQINITFTECAVRVHSLAGDVMTPYMPISLCSDEDRLQAFHSREAKDLSPEITDLPATA 864

  Fly  1310 KVFFWLLGIGLA-FLIVSLFG------YVCYLHK--RKVPSNDLHMNTEVNPFYASMQYIP--DD 1363
            .     .|.|:: |||..|||      :|.|..:  ||:|              ...:|:|  :.
  Fly   865 S-----HGRGISIFLICFLFGCSVSLVWVLYKRRCWRKLP--------------GLRRYVPVREQ 910

  Fly  1364 WEVLRE 1369
            |  ||:
  Fly   911 W--LRD 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	46/112 (41%)
		Furin-like	510..645	CDD:395614	43/137 (31%)
		Recep_L_domain	663..781	CDD:460032	33/117 (28%)
		FN3	791..>964	CDD:442628	43/197 (22%)
		FN3	1224..1302	CDD:238020	21/102 (21%)
		PTKc_InsR_like	1364..1652	CDD:173625	3/6 (50%)
CG10702	NP_724157.1	Recep_L_domain	47..159	CDD:460032	46/111 (41%)
		Furin-like	171..297	CDD:395614	44/164 (27%)
		Recep_L_domain	328..441	CDD:460032	34/129 (26%)