DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and IGF1R

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	XP_016877625.1	Gene:	IGF1R / 3480	HGNCID:	5465	Length:	1392	Species:	Homo sapiens

Alignment Length:	1477	Identity:	544/1477 - (36%)
Similarity:	782/1477 - (52%)	Gaps:	212/1477 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   303 IADGLDKTALSVSGTQSRWTRSESNPTMRLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLID 367
            ||.||.:|.:.|.|                       ..:||||......:|||||||||:|.|.
Human    46 IAQGLPETRIQVCG-----------------------PGIDIRNDYQQLKRLENCTVIEGYLHIL 87

  Fly   368 LINDASPLNRS--FPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLM 430
            ||:.|... ||  |||||.:|:|::::||.||.||..:||||:||||.|||..||||::...:|.
Human    88 LISKAEDY-RSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLK 151

  Fly   431 DLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIRI 495
            |:||:.||:||||.:|||||..|||..|:||..||.......:|  .|...|||. ..|||.:..
Human   152 DIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIV--GNKPPKECG-DLCPGTMEE 213

  Fly   496 EEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKC-RNNCIDEHTCCSQDCLGGCVIDKN 559
            :...:.|.|..|.|..         ||.:..||..||..| :..|.:.:.||..:|||.|....|
Human   214 KPMCEKTTINNEYNYR---------CWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDN 269

  Fly   560 GNESCISCRNVSFNNICMDSCPKGYYQFDS-RCVTANECITLTKFETNSVYSGIPYNGQCITHCP 623
             :.:|::||:..:..:|:.:||...|:|:. |||..:.|..:...|::.....:.::|:|:..||
Human   270 -DTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECP 333

  Fly   624 TGYQKSENKRM-CEPCPG---GKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAH 684
            :|:.::.::.| |.||.|   ..|::|..:..|||:..|:...||||..|.  |.|:|:|  |.:
Human   334 SGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGN--LLINIRR--GNN 394

  Fly   685 VMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWG 749
            :..||:..:..:..:...:.:..::.|.||.|.::|..|.|:..::.: |:.|||||::|.:||.
Human   395 IASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGN-YSFYVLDNQNLQQLWD 458

  Fly   750 -PNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTL 813
             .::.:.|:.|.::|.||||||||.|.::..:..:|.: ..|.|:...:||.|.||.:.||:.|.
Human   459 WDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGR-QSKGDINTRNNGERASCESDVLHFTS 522

  Fly   814 QSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDR 876
            .:...|..::.       ....:|       .|.|..|.|..|:...|:.|.|: ...|.| .:.
Human   523 TTTSKNRIIIT-------WHRYRP-------PDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNS 573

  Fly   877 WK---VSSPEKSGV---MVLSNLIPYTNYSYYVR----TMAISSELTNAESDVKNFRTNPGRPSK 931
            |.   |..|....|   ::|..|.|:|.|:.||:    ||..:..:..|:|::...|||...||.
Human   574 WNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSI 638

  Fly   932 VTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPT-----RNNNRDYCTE---PLVKA 988
            ..:|::.:.|.|::.|.|:....|.|.|:.|.::.:  .:|.     |:|   ||::   |:.|.
Human   639 PLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQ--RQPQDGYLYRHN---YCSKDKIPIRKY 698

  Fly   989 MEN--DLPATTPTKKISDPLAGD----CKC--VEGSKKTSSQEYDDRKVQAGMEFENALQNFIFV 1045
            .:.  |:...|...| ::...|:    |.|  .|..|:...:|.:.|||     |||.|.|.|||
Human   699 ADGTIDIEEVTENPK-TEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKV-----FENFLHNSIFV 757

  Fly  1046 PNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITD 1110
            |                                .|.|:||||.      .|..:.:....|:.|
Human   758 P--------------------------------RPERKRRDVM------QVANTTMSSRSRNTT- 783

  Fly  1111 DTDAFFEKDDENTYK--DEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEI 1173
                     ..:||.  |.|:|.:...|:|    ....|:...|...||.||.|.|.:.:|..|
Human   784 ---------AADTYNITDPEELETEYPFFE----SRVDNKERTVISNLRPFTLYRIDIHSCNHE- 834

  Fly  1174 PSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEI 1238
             :|||.        ||..:.||..|...:.||   |:...:......|:.:.::|..|.:|||.|
Human   835 -AEKLG--------CSASNFVFARTMPAEGAD---DIPGPVTWEPRPENSIFLKWPEPENPNGLI 887

  Fly  1239 VTYEVAYKLQKPDQVEEKKCIPAADFNQTAG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKV 1302
            :.||:.|..|..||   ::|:...::.:..| .|.:||.|.|:.|::|.|::|.|.:|:.....|
Human   888 LMYEIKYGSQVEDQ---RECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYV 949

  Fly  1303 EPPPSYAKVFFWLLGIGLA-FLIVSLFGYVCYLHKRKVPSNDLH---MNTEVNP--FYASMQYIP 1361
            :....|......::.:.:| .|||.....:.|:..||..::.|.   :...|||  |.|:..|:|
Human   950 QAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVP 1014

  Fly  1362 DDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVM 1426
            |:|||.||.|.....||||||||||||:.|....:..:...|||||||.|:.|||..||:|||||
Human  1015 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVM 1079

  Fly  1427 KEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPP 1491
            |||:.:||||||||.|:|||.||:||||.:||||||||:.|||..:..::.            ||
Human  1080 KEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLA------------PP 1132

  Fly  1492 TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKG 1556
            :..::.|||.|||||||||.|.|||||||||||||||:|.||||||||||||||||||||||.||
Human  1133 SLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKG 1197

  Fly  1557 LLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENC 1621
            |||||||.||||:|||:::.|||:||||||||:||||.|||||||||||||:|::||::::|:||
Human  1198 LLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNC 1262

  Fly  1622 PDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDA 1686
            ||.|.:||:.||.:....|||||:||:.::.:. ...|:|||||:||      |.:..|..:||.
Human  1263 PDMLFELMRMCWQYNPKMRPSFLEIISSIKEEM-EPGFREVSFYYSE------ENKLPEPEELDL 1320

  Fly  1687 ----FAAVPLDQD-------LQDREQQEDATTPLRMGDYQQNSSLDQ 1722
                ..:||||..       |.||.....|......|.....:|.|:
Human  1321 EPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDE 1367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	63/110 (57%)
		Furin-like	512..645	CDD:279142	39/138 (28%)
		FU	545..592	CDD:238021	16/47 (34%)
		Recep_L_domain	663..781	CDD:279382	40/118 (34%)
		FN3	1224..1302	CDD:238020	25/78 (32%)
		PTKc_InsR_like	1364..1652	CDD:173625	186/287 (65%)
		Pkinase_Tyr	1371..1650	CDD:285015	181/278 (65%)
IGF1R	XP_016877625.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	365	1.000	Domainoid score	I933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30997
Inparanoid	1	1.050	809	1.000	Inparanoid score	I488
Isobase	1	0.950	-	0	Normalized mean entropy	S4340
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm41905
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4609
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.960