Protein Alignment InR and Ror

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_476962.1
• Gene: Ror / 34367
• FlyBaseID: FBgn0010407
• Length: 685
• Species: Drosophila melanogaster
• Alignment Length: 618
• Identity: 163/618 - (26%)
• Similarity: 285/618 - (46%)
• Gaps: 128/618 - (20%)

  Fly  1125 KDEEDLSSNKQFY---EVFAKELP----PNQTHFVF--------EKLRHFTRYAIFVVACREEIP 1174
            |:.:|:::|.:.|   .:....:|    |.:|:.::        ::|::       |...|:...
  Fly    81 KESKDMNANCRMYALPSLCFSSMPICRTPERTNLLYFANVATNAKQLKN-------VSIRRKRTK 138

  Fly  1175 SEKLRDTSFKKSLCSDYDTVFQTTKRKKF----------------ADIVMDLKVDLEHANNTESP 1223
            |:.:::.|..|...:.|:.||.|....|:                .:::.:.....|:|.....|
  Fly   139 SKDIKNISIFKKKSTIYEDVFSTDISSKYPPTRESENLKRICREECELLENELCQKEYAIAKRHP 203

  Fly  1224 ----VRVRWTPPVDPNGEIVTYEVAYKLQKPD----------------QVEEKKCI-------PA 1261
                |.|.....:..:.:.::..:..::.|.:                ....|.|:       ..
  Fly   204 VIGMVGVEDCQKLPQHKDCLSLGITIEVDKTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEI 268

  Fly  1262 ADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYA-KVFFWLLGIGLAFLIV 1325
            :||.:..|.....|.|...     ||...:.|.:....|::...|..| |::..::|...|.:::
  Fly   269 SDFPELIGQNYCRNPGSVE-----NSPWCFVDSSRERIIELCDIPKCADKIWIAIVGTTAAIILI 328

  Fly  1326 SLFGYVCYLHKRK--------------VPSND--LHMNTEVNPFYAS--------MQYIPDDWEV 1366
            .:..:...|.||:              .||.|  ::.|:::|....:        ..::..:.::
  Fly   329 FIIIFAIILFKRRTIMHYGMRNIHNINTPSADKNIYGNSQLNNAQDAGRGNLGNLSDHVALNSKL 393

  Fly  1367 LRENIIQ------------LAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNF 1419
            :..|.:.            |..||:|:||.||:|.|  ..||......|||.:.|||:.:.:.:|
  Fly   394 IERNTLLRINHFTLQDVEFLEELGEGAFGKVYKGQL--LQPNKTTITVAIKALKENASVKTQQDF 456

  Fly  1420 LSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEE-RDEAMMTYLNRIG 1483
            ..|..::.:....::|.:|||....:|..::.|.|..|||..:|.::.|.| :..:.:.:|
  Fly   457 KREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQLEFL---- 517

  Fly  1484 VTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD 1548
                          |:|::|::||.||:|..:||||||||||:|.:.|.|||.|||::||||.:|
  Fly   518 --------------QIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSD 568

  Fly  1549 YYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGG 1613
            |||..:|.||||||||.||:..|.:::.|||:||||||||:.:...|||.|.||::|:..:....
  Fly   569 YYRVQSKSLLPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQ 633

  Fly  1614 VMERPENCPDFLHKLMQRCWHHRSSARPSFLDI 1646
            ::..|||||..::.||..|||.:|..||:|.||
  Fly   634 LLSAPENCPTAVYSLMIECWHEQSVKRPTFTDI 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	14/100 (14%)
		PTKc_InsR_like	1364..1652	CDD:173625	115/296 (39%)
Ror	NP_476962.1	CRD_TK_ROR_like	39..228	CDD:143568	23/153 (15%)
		KR	235..312	CDD:214527	12/81 (15%)
		PTKc_Ror	404..673	CDD:270642	114/283 (40%)