DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Pvr

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001162911.1 Gene:Pvr / 34127 FlyBaseID:FBgn0032006 Length:1577 Species:Drosophila melanogaster


Alignment Length:1557 Identity:314/1557 - (20%)
Similarity:522/1557 - (33%) Gaps:559/1557 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   671 EPLTISIKRES-GAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKY 734
            :||...:.|.| ..||..:..:.|    ..:.|..|...||::                      
  Fly   326 KPLPKPVIRSSVEHHVFTDTNFTL----DCEQSAYVESVYGME---------------------- 364

  Fly   735 ALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTI---NQLLPMLASKPKFFEKSDVG-- 794
              :...:||.:.::......           :||...||.   ...|.:|.::|     ||.|  
  Fly   365 --WFTPSRDENRIFASQSRT-----------DPKTRNSTHQTGRSTLTVLNAQP-----SDTGLY 411

  Fly   795 ----ADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEP------QKPSNATIVFKDPRA 849
                .|::.......|..:.|..|    |.:.|||      |||      |:.:|.||  :....
  Fly   412 KCVTTDNSNQNVQRATYRIKVLKQ----NESYLNV------GEPSGHYNVQEYANRTI--QMTAN 464

  Fly   850 FIGF--VFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSEL 912
            |.||  ..:....|.|...:.|    ::.:|:.|.|.|.::.:.|.....:.:|.:|. :.|..:
  Fly   465 FEGFPTPSFSWFKPDGTEVRQS----ENNFKILSTELSTMLQVLNAQLQDSGTYVLRG-SNSFGV 524

  Fly   913 TNAESDVKNFRTNPGRPSKVTEVVATAISDSKINV---------TWSYLDKPYGVLTRYFIKAKL 968
            ...|.:|           .|.:..|..:||:.:.|         ..||   |..::|.:|....|
  Fly   525 VQREYNV-----------SVMDAPALKMSDAYVQVGSVARLECTVRSY---PPAIVTFFFRPCSL 575

  Fly   969 ---------INR----PTRNNNRDYCTEPLVKAMENDLPATTPTKKI-------SDPLAGDCKCV 1013
                     :|:    |:......:.|.|        .|.....::|       ::|  |...|:
  Fly   576 EPQWPTCSVLNQNFSLPSEQEKYQFQTRP--------RPGKLSVERIYEVSFLPTEP--GILTCI 630

  Fly  1014 EGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGAT 1078
                   :|...|     |.|.....:..:.:.||  |:|.:....|.....|.:.|.       
  Fly   631 -------AQNIID-----GKERRTLTKAHVLLGNI--SENMTIYGFDKDHKIAKEDNV------- 674

  Fly  1079 NPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKE 1143
                                        :.|.:..|:....:...:.:.|||..:...:      
  Fly   675 ----------------------------NFTCEALAYHFDGNLKWFINGEDLKESDSVH------ 705

  Fly  1144 LPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQT----------- 1197
            :..:.|.:.::...|.|..            |::.|.|...::..:|.|.|:.:           
  Fly   706 IETSHTKYSYKSTVHITTI------------SDRDRGTYECRAYHNDKDAVYSSREIDLYVHDPS 758

  Fly  1198 --------------TKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQ 1248
                          .|||      :...::||.|:.......|||   ...:.|:...::.:.::
  Fly   759 APQWTNGGQEGHSKIKRK------LSQTLELECASTAVPVAIVRW---FKDDKEVTESKLRHIIE 814

  Fly  1249 KPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFF 1313
            |    |.|..|.         :|...:||:|...|..........||.|    :...|..:..:.
  Fly   815 K----ESKLLIT---------HLYPGDEGVYKCVVENRLDRIERSFTVV----ISDLPGISMAWV 862

  Fly  1314 WLLGIGLAFLIVSLFGYVCYL-------HKRKV-------------------PSNDLHMNTEVNP 1352
            | .|: :.|||  |.|...:|       |||.:                   |...|....|:.|
  Fly   863 W-FGV-ILFLI--LIGLCVFLAVRYQKEHKRHLALKAAGLANFEEGAVGHINPDLTLDEQAELLP 923

  Fly  1353 FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRE-----CAIKTVNENAT 1412
            :..       ::|..|||:.....||.|:||:|.:|..|     |:.||     .|:|.|...|.
  Fly   924 YNR-------EFEFPRENLKLGKQLGAGAFGVVLKGEAK-----GIRREEPTTTVAVKMVKATAD 976

  Fly  1413 DRERTNFLSEASVMKEFDTY-HVVRLLGVCSRG---QPALVVMELMKKGDLKSYLRAHR------ 1467
            :......:||..:|.....: :||.|||..::.   :..:|::|..:.|:::::|..:|      
  Fly   977 NEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNRKCFINQ 1041

  Fly  1468 ----PEERDEAMMT-------------------YLNRIGV----------TGNVQPPTYGR---- 1495
                .:..|.::||                   |.| :|.          ..|.||||:.|    
  Fly  1042 INPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYAN-VGFPIHSYINEPHNNNTQPPTHRRNSDN 1105

  Fly  1496 ----------------------------------------------------------------- 1495
                                                                             
  Fly  1106 DPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVT 1170

  Fly  1496 ---IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGL 1557
               :...|.::|.||.||::||.:|.||||||.::.:|..|||.|||:.|.:|..|.|:|...|.
  Fly  1171 TVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGK 1235

  Fly  1558 LPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMERPENC 1621
            ||::|:..|||.|.|:|:.|||:|:|:|||||.:||..||.|:. |:::...:.||..||:|:..
  Fly  1236 LPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFA 1300

  Fly  1622 PDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDA 1686
            ...|:::|..||.....:||.|    |.||.:..|...::|:.::                    
  Fly  1301 NQELYEIMLECWRKNPESRPLF----AELEKRFANMLGEDVASHY-------------------- 1341

  Fly  1687 FAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSGFIASST 1751
                   .||.:...|.:.       :|.:..|.|.     :|::                  .:
  Fly  1342 -------LDLNNPYMQSNI-------EYMKKQSTDY-----LALM------------------GS 1369

  Fly  1752 PDGQTVMATAFQNIPAAQGDISATYVVPD--ADALDGDRGYEIYDPSP-KCAEL--PTSRSGSTG 1811
            ||         :..|||...::. ::|||  .:.|..|......|..| .|..:  ||       
  Fly  1370 PD---------ELAPAAPRYVNG-HIVPDIRIEELPDDYMEMSRDSDPDACTAIFSPT------- 1417

  Fly  1812 GGKLSGEQHLLPRKGRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSHTGRPSLKKT------ 1870
              :|.||....|....:.|.   :.|     |:...|:.    |:|.:|.:.:|..||.      
  Fly  1418 --RLEGESSDFPDFSSETTF---NFP-----GARQSPTL----SNNLNSGSSKPLRKKNGMPTVD 1468

  Fly  1871 VADSVRNKANFINRHLFNHKRTGSNASHKS-------------NASNAPSTSSNTNLTSHPVAMG 1922
            |||....:...::|     ..|||:.|.:.             ..:.:|.....|.|...|    
  Fly  1469 VADQAPEEIPMLHR-----SSTGSDGSPEQGRRFNQALKQQYVTPTPSPRHHVETKLNGEP---- 1524

  Fly  1923 NLGTIESGGSGSAGSYTG--TPRFYTPSATPGGGSGMAIS------DNPNYRLLDESIASEQ 1976
                        :.:|..  .||...|..|..||.|.|..      .||:|:.|......||
  Fly  1525 ------------SENYVNMKPPRKNIPGKTTTGGGGAAAGASTEAFSNPSYQPLSTVNEKEQ 1574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032 18/113 (16%)
FN3 791..>964 CDD:442628 43/195 (22%)
FN3 1224..1302 CDD:238020 16/77 (21%)
PTKc_InsR_like 1364..1652 CDD:173625 111/408 (27%)
PvrNP_001162911.1 IG_like 346..432 CDD:214653 19/129 (15%)
Ig strand C 363..366 CDD:409353 0/26 (0%)
Ig strand E 396..400 CDD:409353 1/3 (33%)
Ig strand F 410..415 CDD:409353 0/4 (0%)
Ig strand G 425..428 CDD:409353 0/2 (0%)
Ig 458..533 CDD:472250 18/92 (20%)
Ig strand B 459..463 CDD:409353 1/5 (20%)
Ig strand C 472..476 CDD:409353 0/3 (0%)
Ig strand E 497..503 CDD:409353 1/5 (20%)
Ig strand F 513..518 CDD:409353 1/4 (25%)
Ig 671..>742 CDD:472250 13/123 (11%)
Ig strand B 674..678 CDD:409353 0/38 (0%)
Ig strand C 687..691 CDD:409353 0/3 (0%)
Ig strand E 717..721 CDD:409353 0/3 (0%)
Ig strand F 731..736 CDD:409353 1/4 (25%)
Ig 779..851 CDD:472250 19/91 (21%)
Ig strand B 781..785 CDD:409570 1/3 (33%)
Ig strand C 794..798 CDD:409570 3/6 (50%)
Ig strand E 816..821 CDD:409570 2/4 (50%)
Ig strand F 831..836 CDD:409570 1/4 (25%)
Ig strand G 844..847 CDD:409570 0/2 (0%)
Protein Kinases, catalytic domain 927..1332 CDD:473864 112/414 (27%)
Blue background indicates that the domain is not in the aligned region.

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