DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and CG3277

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_608762.3	Gene:	CG3277 / 33543	FlyBaseID:	FBgn0031518	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	816	Identity:	183/816 - (22%)
Similarity:	290/816 - (35%)	Gaps:	303/816 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1070 NAI---PNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLS 1131
            ||:   |...||||:                   |:..|||               :.|:.|.:.
  Fly    22 NAVGQAPRENATNPT-------------------LISLVRS---------------SEKEPEQME 52

  Fly  1132 SNKQ---FYEVFAKE------LPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLR-------D 1180
            |::.   ..|..|.|      |.||....:.|...:.|.|       .|:||..::|       .
  Fly    53 SHRYVTGLSEPIAMEPLTRMRLNPNPDGEITELTTNVTLY-------MEKIPRLQVRWQDNLPQG 110

  Fly  1181 TSF-------KKSLCSD------------------------------------------YDTVFQ 1196
            ||:       ..|.|.|                                          |..:.:
  Fly   111 TSYNVLVSAVNNSRCPDAPCSEYGIKEKNASAETHSVNLPVNPNLNVESVDCNYMFGCQYQVIVE 175

  Fly  1197 TTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPP-------------VDPNGEIVTYEV----- 1243
            |:.    |.:....:|.:......:...::..|||             :..|..|:..|:
  Fly   176 TSN----AMVRRSARVYIPQCLEGKCSCQLAPTPPKVLAVAKMLSNETISINLSILASELLRKEQ 236

  Fly  1244 ---------AYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLY-----SFRVRANSIAG---Y 1291
                     .||:|.....|....:|      ..|.|..|...:|     :||.......|   .
  Fly   237 DSHLHETLRTYKMQLKINEETNPSLP------WGGVLKHLMTRVYKLSELNFRATPKGFEGVMKL 295

  Fly  1292 GDFTEVEH--------IKVEP-----PPSYAKV----------------------FFWLLGIGLA 1321
            |..|:::.        :.::|     |.|..||                      ...|:.|.||
  Fly   296 GLGTQLKEKASLSLQAVIIDPTGCEGPRSVTKVPVPANPVLLTEGDSVSNSIIVMSAMLIAIILA 360

  Fly  1322 FLIVSLFGYVCYLHKRKV-----------------PSNDLHMNTEVNPFYASMQYIPDDWEVLRE 1369
            .||:.|      |.:|:.                 .::.:.|...||       |:  |..|.:.
  Fly   361 GLIMLL------LRRRRARTTAKLRKQEQIYIQTFATSAIEMEDNVN-------YV--DKYVEKS 410

  Fly  1370 NIIQLAP--------------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFL 1420
            .::.||.              ||:|:||.|:|....:..........|:|.:..|....|...:|
  Fly   411 QVLGLADIFEVPHSAIQIGRMLGEGAFGQVHEATAINLRRMRGTTIVAVKQLKPNPKADEVAEYL 475

  Fly  1421 SEASVMKEFDTYH-VVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERD-----------E 1473
            :|..::|...|:| ||..||.|:...|.|::||.:.||:|.||||..|.|...           .
  Fly   476 AEIEMLKGVGTHHNVVSFLGCCTIKPPYLMIMEYVNKGNLLSYLRTVRKEASKLRNRNANYTSCR 540

  Fly  1474 AMMTYLNRIG-----------------------------VTGNVQP-PTYG-------------- 1494
            .:||..|...                             :.|..|| |::.
  Fly   541 PIMTRTNSTSSPKSQSVNYIELKASSQTIEMPQEDSTAHMNGIRQPHPSFAETTYTIVEDEDAFE 605

  Fly  1495 ------RIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR-DIYETDYYRK 1552
                  .::..|::||:||.:|..::..||||||||.::..:.|:||.|||::| .||.....||
  Fly   606 YILDNKELHNFALQIANGMRFLEEQEITHRDLAARNVLIDSNKTLKISDFGLSRHGIYTNTRTRK 670

  Fly  1553 GTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMER 1617
                 ||:||:..|::|:.||||.||::::||||||:.||.|.||..:||::::.:::.|..:||
  Fly   671 -----LPLRWLSIEAIRENVYSSKSDIWAYGVVLWEIGTLGASPYPTISNDELIPFLMAGNRLER 730

  Fly  1618 PENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQ 1653
            ||.|...::.:|.:||......||:|..:...|.|:
  Fly   731 PEICTPQVYTIMLQCWLEEPEERPTFDALYKVLSPK 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020	20/120 (17%)
		PTKc_InsR_like	1364..1652	CDD:173625	107/364 (29%)
		Pkinase_Tyr	1371..1650	CDD:285015	105/355 (30%)
CG3277	NP_608762.3	STYKc	426..763	CDD:214568	103/341 (30%)
CG3277	NP_608762.3	PTKc	430..763	CDD:270623	103/337 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940