DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and sev

DIOPT Version :9

Sequence 1:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_511114.2 Gene:sev / 32039 FlyBaseID:FBgn0003366 Length:2554 Species:Drosophila melanogaster


Alignment Length:951 Identity:244/951 - (25%)
Similarity:365/951 - (38%) Gaps:250/951 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   857 HMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNY-------SYYVRTMAISSELTN 914
            |.::|.|            :|.:.:.|.   :.|::|:|:|.|       |:|.:.:|:.: |..
  Fly  1739 HGMEPLG------------QWLLGAGES---LNLTDLLPFTRYRVSGILSSFYQKKLALPT-LVL 1787

  Fly   915 AESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRD 979
            |..::......|..|...:   ...:|..::.|:|                  |.....|:.:..
  Fly  1788 APLELLTASATPSPPRNFS---VRVLSPRELEVSW------------------LPPEQLRSESVY 1831

  Fly   980 YCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIF 1044
            |...                                    ..||.|...||...|:|        
  Fly  1832 YTLH------------------------------------WQQELDGENVQDRREWE-------- 1852

  Fly  1045 VPNIRKSKNGSSDKSDGAEGAA-----LDSNAIPNGGATNPSRRRRDVALEPELDDVE-GSVLLR 1103
             .:.|:.:...:.:..|.:..:     :.::|.|....::.....|..|..|||..:| |...|.
  Fly  1853 -AHERRLETAGTHRLTGIKPGSGYSLWVQAHATPTKSNSSERLHVRSFAELPELQLLELGPYSLS 1916

  Fly  1104 HVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVA 1168
            ...:.|.|.....:.         |..||.:|    ..:.:..|.|..|.|.|:..|||     .
  Fly  1917 LTWAGTPDPLGSLQL---------ECRSSAEQ----LRRNVAGNHTKMVVEPLQPRTRY-----Q 1963

  Fly  1169 CREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVD 1233
            ||..:.................|:|:.....:..        |..|||.  .|...||.||....
  Fly  1964 CRLLLGYAATPGAPLYHGTAEVYETLGDAPSQPG--------KPQLEHI--AEEVFRVTWTAARG 2018

  Fly  1234 PNGEIVTYEVAYKLQKPDQVEEKK------------CIPAA-----------DFNQTA--GYLIK 1273
            ....|..|.:. .||....:..::            .:|.|           ||..|.  ..::|
  Fly  2019 NGAPIALYNLE-ALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVK 2082

  Fly  1274 L--NEGLYSFRVRANSIA-GYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYL- 1334
            .  :..|..|||||.|:. |:|.::|......||..|..|....:|.|.....|||    .|.| 
  Fly  2083 SLHSSRLLLFRVRARSLEHGWGPYSEESERVAEPFVSPEKRGSLVLAIIAPAAIVS----SCVLA 2143

  Fly  1335 -------HKRKVPSNDLHMNTEVNPFYASMQYIPDDWE---------------------VLRENI 1371
                   .||::.:..|           ..|..|..|.                     .|.:..
  Fly  2144 LVLVRKVQKRRLRAKKL-----------LQQSRPSIWSNLSTLQTQQQLMAVRNRAFSTTLSDAD 2197

  Fly  1372 IQLAP------------LGQGSFGMVYEGILK---SFPPNGVDRECAIKTVNENATDRERTNFLS 1421
            |.|.|            ||.|:||.||||.||   |..|..|    |||::.:.|:  |....|.
  Fly  2198 IALLPQINWSQLKLLRFLGSGAFGEVYEGQLKTEDSEEPQRV----AIKSLRKGAS--EFAELLQ 2256

  Fly  1422 EASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTG 1486
            ||.:|..|...::|.|:|:|...:...::||.|:.|||.|||||.|                .|.
  Fly  2257 EAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAAR----------------ATS 2305

  Fly  1487 NVQP-PTYG----RIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDL-------TVKIGDFG 1539
            ..:| ||.|    .:..|.|::|:|.:||....|||||||.|||:|.:..       ||||||||
  Fly  2306 TQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFG 2370

  Fly  1540 MTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQ 1604
            :.||||::|||||..:||||||||.||||.||::::.|||::|||:.||:.||..|||...:|.:
  Fly  2371 LARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFE 2435

  Fly  1605 VLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEA 1669
            ||.:|.:||.:::|..|.:.|:.|:..||......||||......|.....:.:..:::...::.
  Fly  2436 VLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQMASATADT 2500

  Fly  1670 GLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLR 1710
            .:.....|.|.|     |...||::..:..|:.||....||
  Fly  2501 VVSCSRPEFKVR-----FDGQPLEEHREHNERPEDENLTLR 2536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382
Furin-like 512..645 CDD:279142
FU 545..592 CDD:238021
Recep_L_domain 663..781 CDD:279382
FN3 1224..1302 CDD:238020 24/105 (23%)
PTKc_InsR_like 1364..1652 CDD:173625 128/335 (38%)
Pkinase_Tyr 1371..1650 CDD:285015 125/305 (41%)
sevNP_511114.2 fn3 439..520 CDD:278470
FN3 826..921 CDD:238020
LY 993..1026 CDD:214531
FN3 1292..1374 CDD:214495
FN3 1799..1897 CDD:238020 19/163 (12%)
FN3 1993..2111 CDD:238020 29/128 (23%)
Pkinase_Tyr 2209..2481 CDD:285015 122/293 (42%)
PTKc_c-ros 2213..2483 CDD:270640 123/291 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45455274
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24416
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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