Protein Alignment InR and Ephb6

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001101327.1
• Gene: Ephb6 / 312275
• RGDID: 1306163
• Length: 1013
• Species: Rattus norvegicus
• Alignment Length: 742
• Identity: 166/742 - (22%)
• Similarity: 285/742 - (38%)
• Gaps: 198/742 - (26%)

  Fly   970 NRPTRNNNR-DYCTEPLVKAMENDLPAT-TPTKKIS-DPLAGDCKCVEGSKKTSSQEYDDRKVQA 1031
            ::|.|.:.. ..|.|...||:..::|.: .|.:..| ||.|..|.|::|..:.||..
  Rat   299 HQPARGDKLCQACPEGSYKALPGNVPCSPCPARSHSPDPAAPVCPCLQGFYRASSDP-------- 355

  Fly  1032 GMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDV 1096
                                                     |....|.|....|::..|     |
  Rat   356 -----------------------------------------PEAPCTGPPSAPRELWFE-----V 374

  Fly  1097 EGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQ-FYEVFAKEL-----PP--------- 1146
            :||.|:.|                   ::..::|..... .:.|..||.     |.
  Rat   375 QGSALMLH-------------------WRLPQELGGRGDLLFNVVCKECGGHKEPSSGGMCRRCR 420

  Fly  1147 NQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMD-- 1209
            ::.|| ..:.|..|...:.|...|..:|                  .:.:.......:::..|
  Rat   421 DEVHF-DPRQRGLTESRVLVGGLRAHVP------------------YILEVQAVNGVSELSPDPP 466

  Fly  1210 ----LKVDLEH-----------ANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCI 1259
                :.|...|           .:...:.:.|.|..|...||.|:.|::.|.    ||.|::
  Rat   467 QAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNILDYQLRYY----DQAEDE--- 524

  Fly  1260 PAADFNQTA----GYLIKLNEG-LYSFRVRANSIAGYGDFTEVEHIKVEP--------PPSYAKV 1311
             :..|..|:    ..:.:|:.| :|.|:|||.:.||:|.:....:.:..|        |...:.|
  Rat   525 -SHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSLV 588

  Fly  1312 FFWLLGIGLAFLIVSLFGY--VCYLHKRKVPSNDLHMNTEVNP-----FYASMQYIPDDWEVLRE 1369
            ...:|| .||||:::....  |.:..||:.......:....:|     :|.......|..:.:||
  Rat   589 IGSILG-ALAFLLLAAITVLAVIFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYDDPCQAIRE 652

  Fly  1370 NIIQLAP--------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVM 1426
            ...::.|        :|.||||.|..|.|:  |....::..||:.:.....:..:..||..|:::
  Rat   653 LAREVDPTYIKIEEVIGAGSFGEVRRGRLQ--PRGRREQAVAIQALWAGGAESLKMTFLGRAALL 715

  Fly  1427 KEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPP 1491
            .:|...:::||.||.:|.:|.:|:.|||:.|.|.|:||               .|.|...::|
  Rat   716 GQFQHPNILRLEGVVTRSRPVMVLTELMELGPLDSFLR---------------QREGQFSSLQ-- 763

  Fly  1492 TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKG 1556
                :..|...:|..|.||::..||||.|:||:.:|...|..|:...|         :..:|:..
  Rat   764 ----LVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLG---------HSPQGSSS 815

  Fly  1557 LLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENC 1621
            ||  ||..||.:..|.|:::|||:|||:::||:.:...:||..:|:::||..:.....:..|..|
  Rat   816 LL--RWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMSDQEVLNAIEQEFRLPPPPGC 878

  Fly  1622 PDFLHKLMQRCWHHRSSARPSFLDIIA 1648
            |..||.||...|....:.||.|..::|
  Rat   879 PTGLHLLMLDTWQKDRARRPHFDQLVA 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	23/82 (28%)
		PTKc_InsR_like	1364..1652	CDD:173625	86/293 (29%)
Ephb6	NP_001101327.1	EphR_LBD_B6	33..225	CDD:198443
		TNFRSF	294..361	CDD:276900	18/110 (16%)
		CRD2	311..342	CDD:276900	10/30 (33%)
		fn3	365..463	CDD:394996	19/140 (14%)
		fn3	481..563	CDD:394996	23/89 (26%)
		EphA2_TM	604..659	CDD:464211	8/54 (15%)
		Protein Kinases, catalytic domain	657..911	CDD:473864	84/283 (30%)
		SAM_EPH-B6	937..1005	CDD:188954
		PDZ-binding. /evidence=ECO:0000255	1011..1013