Protein Alignment InR and tek

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_009299388.1
• Gene: tek / 30747
• ZFINID: ZDB-GENE-990415-56
• Length: 1117
• Species: Danio rerio
• Alignment Length: 1407
• Identity: 280/1407 - (19%)
• Similarity: 450/1407 - (31%)
• Gaps: 526/1407 - (37%)

  Fly   375 LNRSFPKLTEVTDYIIIYRVT---GLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHK 436
            |.:.||. ||...:.....||   ..|:....:..:....|.|::. |.::..:.|      |.:
Zfish    74 LGQEFPH-TEPRPHPAAATVTWSSRSHAFGAFYCQIRNSTGRKIYT-YKMLQEAAF------LPE 130

  Fly   437 LRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENG-------KEKECRLSKCPGEIR 494
            ..:||   |...:|..:.|.|     .:.:..:|   |:.:||       ||....:...|....
Zfish   131 SLTIT---VNQGENINISYSR-----RLYSPEDT---VIHKNGHFEHSSPKEDISDIIHYPVTNA 184

  Fly   495 IEEGH-------------DTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKCRNN--CIDE-- 542
            ..|.|             .:.||...:..||     |...|... |...|| :|.|.  |.|.
Zfish   185 KAESHAGIYAIRYISAAPSSAAITRLIVRSC-----RAGFWGPN-CTESCP-RCANGGVCDDTTG 242

  Fly   543 ----------HTC------------CSQDCLGG-------CVIDKNGNESCISCRNVSFNNICMD 578
                      |||            |.:.|:.|       |:.|..|.......|.:|    |.|
Zfish   243 ECVCPPGFRGHTCDIVCGEGRFGAGCKERCVDGVCRALVFCLRDPYGCSCASGWRGLS----CND 303

  Fly   579 SCPKGYY--QFDSRCVTANECITLTKFETNSVYSGIPYNGQC--ITHCPTGYQKSENKRMCEPCP 639
            :||.|||  ....:||.|                    .|:|  ...|           :|....
Zfish   304 ACPDGYYGAGCTQKCVCA--------------------KGRCDRFRGC-----------VCAGRH 337

  Fly   640 GGKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLM 704
            |.:|::..||.:|..|....      |.||.|                               |.
Zfish   338 GSRCEEADSSPVISHLRDVE------INTGVE-------------------------------LS 365

  Fly   705 VHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKL 769
            |:.:...:.......:|.|:      |::..:..:|...|::
Zfish   366 VNCSASGRPAPLHGDITLIT------ANRTTIAAVDTHTLND----------------------- 401

  Fly   770 CVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEP 834
                         .....|....|...|.| |..|          .|....|.:.....||:..|
Zfish   402 -------------QSTSVFRVQQVRVSSAG-RWRC----------QVNNTHAQVEDEFTVEVKVP 442

  Fly   835 QKPSNATIV-FKDPRAFIGFVFYHMI-----DPYGNSTKSSDDPCDDRWKVSSPEKS-------- 885
            .:|.|..:: ...||        |::     :||     |.|.|......:..|..:
Zfish   443 PRPQNPPVLQGSGPR--------HLLLLLNTEPY-----SGDGPIATTTLLYRPASAHTWSSFTA 494

  Fly   886 -GVMV-LSNLIPYTNYSYYVRTMAISSELTNAESDVKNFRTNPGRPSKV-------TEVV----- 936
             |.:| |.||.|.|.|            ||    .|:..|..||...:.       |:|:
Zfish   495 HGPLVRLDNLYPMTQY------------LT----QVQLSRPGPGGAGQAGPAATFSTQVLELPVG 543

  Fly   937 --ATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPT 999
              .:|:|.:.:.::|.....                       ..:||.. |..::...|.|..|
Zfish   544 VKLSAVSQTALLLSWDIAPA-----------------------EQHCTYE-VSCLQAGAPGTLRT 584

  Fly  1000 KKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEG 1064
            .::             ...:|:....|.|.                   |.....:...|.|.
Zfish   585 FQL-------------PSNSSAMHLSDLKP-------------------RHKYQCTVRSSCGV-- 615

  Fly  1065 AALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAF-------------- 1115
                       |..:||.....:: :|||.....::.:.::    .||.|.
Zfish   616 -----------GQNHPSASAWTLS-DPELPPPPANISIWNI----SDTSAVLTWAVAEGESVSRA 664

  Fly  1116 ---FEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFE--KLRHFTRYAIFVVACREEIPS 1175
               |::.::..|:.:.:|....|            |.|..|:  .||..|.|
Zfish   665 VIRFQQVEQAQYRQQVELPVQTQ------------QLHMRFQLLGLRPNTGY------------- 704

  Fly  1176 EKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANN----TESPVRVRWTPPVD--- 1233
                                               ::.|...||    .|||.....|.|..
Zfish   705 -----------------------------------QLQLWTVNNMGESAESPPVSLMTLPQQESS 734

  Fly  1234 ----PNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAG---------YLIKLNEGLYSFRVRA 1285
                .:|.::.|.:.                     .:||         :.|.|.....:.:.|.
Zfish   735 ALFAAHGHLLLYAIL---------------------GSAGMTCCTVLLAFCIVLQLKRNTLQRRI 778

  Fly  1286 NSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRK-VPSNDLHMNTE 1349
            :||...   ....|....|||                            |:|. |.|..|
Zfish   779 HSILRE---EPAVHFSSAPPP----------------------------HRRSAVVSRSL----- 807

  Fly  1350 VNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDR 1414
               .:.::|     |..::...:    ||:|:||.|.:..::.   :|:..:.|:|.:.:.|:..
Zfish   808 ---VFPALQ-----WSDIQFQDV----LGEGNFGQVLKARIRK---DGLRMDAAVKRMKDYASQD 857

  Fly  1415 ERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTY 1478
            :..:|..|..|:.....: :::.|||.|.......:.:|....|:|..:||..|..|.|.| ...
Zfish   858 DHRDFAGELEVLCRLGPHKNIIHLLGACEHRGYLYLAIEFAPHGNLLDFLRKSRVLETDPA-FAI 921

  Fly  1479 LNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRD 1543
            .:|...|.:.|     ::...:.::|.||:||:.|:|:||||||||.:|.::...||.|||::|.
Zfish   922 AHRTASTLSSQ-----QLLAFSADVARGMSYLSQKQFIHRDLAARNVLVGENFVAKIADFGLSRG 981

  Fly  1544 IYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRY 1608
               .:.|.|.|.|.||||||..|||...||::.|||:|:||:|||:.:|...||.|::..::...
Zfish   982 ---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEVVSLGGTPYCGMTCAELYEK 1043

  Fly  1609 VIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL 1650
            :..|..:|:|.||.|.:::|||:||..:...||||..|:..|
Zfish  1044 LPLGFRLEKPLNCDDEVYELMQQCWREKPFERPSFSQILLSL 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	19/92 (21%)
		Furin-like	510..645	CDD:395614	38/171 (22%)
		Recep_L_domain	663..781	CDD:460032	11/117 (9%)
		FN3	791..>964	CDD:442628	40/202 (20%)
		FN3	1224..1302	CDD:238020	12/93 (13%)
		PTKc_InsR_like	1364..1652	CDD:173625	97/288 (34%)
tek	XP_009299388.1	Ig_Tie2_1	25..121	CDD:463089	11/48 (23%)
		EGF_CA	<231..255	CDD:238011	5/23 (22%)
		Ig	348..437	CDD:472250	21/178 (12%)
		Ig strand B	364..368	CDD:409353	2/3 (67%)
		Ig strand C	380..384	CDD:409353	1/3 (33%)
		Ig strand E	405..409	CDD:409353	1/3 (33%)
		Ig strand F	419..424	CDD:409353	2/14 (14%)
		Ig strand G	432..435	CDD:409353	0/2 (0%)
		fn3	541..621	CDD:394996	16/148 (11%)
		FN3	633..717	CDD:214495	17/147 (12%)
		PTKc_Tie2	809..1111	CDD:133219	98/298 (33%)