Protein Alignment InR and Csf1r

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001424441.1
• Gene: Csf1r / 307403
• RGDID: 2425
• Length: 978
• Species: Rattus norvegicus
• Alignment Length: 1042
• Identity: 237/1042 - (22%)
• Similarity: 390/1042 - (37%)
• Gaps: 236/1042 - (22%)

  Fly   816 VGANSAMLNVTTKVEIGEPQ-KPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKV 879
            :||...:|..|.....|.|. :||...:|. :|.|.:      .:....|.:...|.|....|.:
  Rat     3 LGAPLVLLLATAWHGQGAPVIEPSGPELVV-EPGATV------TLRCVSNGSVEWDGPISPYWTL 60

  Fly   880 SSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAESDVKNFRTNPGRP-----SKVT------ 933
            .|.....:::..| ..:.|...| |...:...:..:.: :..:..:|.||     .:||
  Rat    61 DSESPGSILITKN-ATFKNTGTY-RCTELEDPMRGSTA-IHLYVKDPVRPWNLLAQEVTVFEGQE 122

  Fly   934 EVVATAISDSKINVTWSYL---DKPYGVLTRY-------FI--KAKLINRPTRNNNRDYCTEPLV 986
            .|:...|:|..:..:.|.:   .:|....|.|       ||  |||.::..|      |..:.:|
  Rat   123 AVLPCLITDPTLKDSVSLVREWGRPVSRKTVYSFLPWRGFIIHKAKFLDSHT------YMCKAVV 181

  Fly   987 KAMENDL-----------PA-----TTPTKKISDPLAGDCKCVEGSKKTSSQEYD------DRKV 1029
            .|.|:..           |.     ..|||.:.  :.|:...:..|...|..|::      |.|:
  Rat   182 NARESTSIGIRLKVNRAHPGPPHIILEPTKLVR--IRGEAAQIVCSATHSEVEFNVILKRGDTKL 244

  Fly  1030 Q--AGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPE 1092
            :  ...:|::.....:...|:     .:.|..|    |.:.|....|...:|.:.....|.....
  Rat   245 EIPINSDFQDNAYKKVLTLNL-----NAVDFQD----AGIYSCVANNAAGSNTATMNFQVVESAY 300

  Fly  1093 LDDVEGSVLLRHVR-----SITDDTDAFFEKDDEN-TY-----KDEEDLSSNKQFYEVFAKELPP 1146
            |:......||:.|.     .:|...||:......| ||     :|..:|....|:
  Rat   301 LNLTSEQSLLQEVSVGENLDLTVIADAYPGLQRYNWTYLGPFFEDPHNLEFRTQW---------- 355

  Fly  1147 NQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKR----------- 1200
              |.:.:....|..|..          |.|..|.:...::.....:..|:.|.|
  Rat   356 --TTYSYSFKLHLNRVK----------PLEAGRYSLMAQNKAGWNNLTFELTLRYPPEVSVTWIP 408

  Fly  1201 KKFADIVM-DLK-------VDLEHANNT----ESPVRVRWTPPVDPNGEIVTYEVAYKLQKP-DQ 1252
            ...:|::: |:.       ..:|...:|    |:.....|.   |...|:::       ||| .:
  Rat   409 VNGSDVLLCDVSGYPQPNVTWMECRGHTDRCDEAQASQVWD---DTQPEVLS-------QKPFHR 463

  Fly  1253 VEEKKCIPAADFNQTAGYLIKL--NEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWL 1315
            |..:..:|.........|:.:.  |.|..|...||.|:   |...::       |..|......:
  Rat   464 VILQSQLPIGTLKHNMTYVCRAHNNVGNSSQFFRAISL---GQSKQL-------PDEYLFTPVVV 518

  Fly  1316 LGIGLAFLIVSLFGYVCYLHKRK---------VPSNDLHMNTEVNPFYASMQYIPDDWEVLRENI 1371
            ..|.:..|:|.|...:.|.:|:|         :.|.:.:..|.::|  ..:.| .:.||..|.|:
  Rat   519 ACISVMSLLVLLLLLLLYKYKQKPKYQVRWKIIESYEGNNYTFIDP--TQLPY-NEKWEFPRNNL 580

  Fly  1372 IQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVV 1435
            .....||.|:||.|.|.............:.|:|.:...|...|:...:||..:|.....: ::|
  Rat   581 QFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIV 645

  Fly  1436 RLLGVCSRGQPALVVMELMKKGDLKSYLR-------------AHRPE---------------ERD 1472
            .|||.|:.|.|.||:.|....|||.::||             ...||               .||
  Rat   646 NLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGDSSYKNIHLEKKYVRRD 710

  Fly  1473 -----EAMMTY--LNRIGVTGN------------VQPPTYGRIYQMAIEIADGMAYLAAKKFVHR 1518
                 :.:.||  :..:..:.|            .:|.....:...:.::|.|||:||:|..:||
  Rat   711 SGFSSQGVDTYVEMRPVSTSSNDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHR 775

  Fly  1519 DLAARNCMVADDLTVKIGDFGMTRDIY-ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSF 1582
            |:||||.::......||||||:.|||. :::|..|| ...|||:||.|||:.|.||:..|||:|:
  Rat   776 DVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKG-NARLPVKWMAPESIFDCVYTVQSDVWSY 839

  Fly  1583 GVVLWEMATLAAQPYQG-LSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDI 1646
            |::|||:.:|...||.| |.|.:..:.|.||..|.:|...|:.::.:||.||....:.||:|..|
  Rat   840 GILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPENIYSIMQSCWDLEPTKRPTFQQI 904

  Fly  1647 IAYLEPQC------------PNSQFKEVSFYHSEAGLQHREKERKERNQLDAFA-------AVPL 1692
            ...|:.|.            |:|.....|...|..|......|.:|.:..:..|       |.||
  Rat   905 CFLLQEQARLERREQDYANLPSSSSSSSSSSDSGGGSGGSSSEPEEESSSEHLACCEPGDIAQPL 969

  Fly  1693 DQ 1694
            .|
  Rat   970 LQ 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628	32/169 (19%)
		FN3	1224..1302	CDD:238020	16/80 (20%)
		PTKc_InsR_like	1364..1652	CDD:173625	107/337 (32%)
Csf1r	NP_001424441.1	None