DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and epha2a

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_571490.1 Gene:epha2a / 30689 ZFINID:ZDB-GENE-990415-63 Length:984 Species:Danio rerio


Alignment Length:567 Identity:164/567 - (28%)
Similarity:256/567 - (45%) Gaps:117/567 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1138 EVFAKELPPNQTH-FVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRK 1201
            ||...||.|:..: |..|.....::::                    :|...:...||...|...
Zfish   391 EVVVSELEPHVNYTFTVEAQNGVSQFS--------------------RKRAKASITTVLHFTDGP 435

  Fly  1202 KFADIVMDLKVDLEHANNTESPVRVRWTPPVD---PNGEIVTYEVAY-KLQKPDQVE-------- 1254
            :    |:.|:|:    :.|.|.:.:.|.  ||   .|.....||:.| |.:.|.:::        
Zfish   436 R----VLYLRVE----DRTTSSLTLSWA--VDHHVQNQPSPRYELMYRKKEDPGELDVTTYTVLV 490

  Fly  1255 -EKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPP--------SYAK 1310
             ||..:|..|.         |....|.|||...:..|:......| ::.|..|        |...
Zfish   491 LEKNSVPINDL---------LPGTKYVFRVHTLTAEGHPSSHSAE-LEFETLPLAESRTQNSSMV 545

  Fly  1311 VFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYAS--------MQYI-PDDWEV 1366
            |...:.|.|:..|||.:   :..||||::.|   |:...|:..|.|        ..|| |..:|.
Zfish   546 VMGAIAGGGVMLLIVVV---ILLLHKRRLNS---HVRRRVDGDYFSCPEKLLPLKTYIDPHTYED 604

  Fly  1367 LRENIIQLAP------------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNF 1419
            ....|::.|.            :|.|.||.|:.|.||.  |...:...||||:....|:::|.:|
Zfish   605 PCAAILKFASEIHPGHITKQKVIGAGEFGEVFRGSLKM--PGRSEVAVAIKTLKPGYTEKQRQDF 667

  Fly  1420 LSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGV 1484
            |||||:|.:|...:::||.||.::.:.|:::.|.|:.|.|..|||.|..:.....::..||    
Zfish   668 LSEASIMGQFSHKNIIRLEGVVTKFKDAMIITEYMENGALDQYLRDHDGDFSSYQLVGMLN---- 728

  Fly  1485 TGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---DIYE 1546
                             .||.||.||:...:|||||||||.:|..:|..|:.|||::|   |..|
Zfish   729 -----------------GIAAGMKYLSDMNYVHRDLAARNVLVNSNLECKVSDFGLSRVLEDFPE 776

  Fly  1547 TDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVID 1611
            ..|...|  |.:|:||..||::....::|||||:|||:|:||:.:...:||..:||::|::.:.|
Zfish   777 GTYTTTG--GKIPIRWTAPEAIAYRKFTSASDVWSFGIVMWEVMSFGERPYWDMSNQEVMKSIND 839

  Fly  1612 GGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQ 1658
            |..:..|..||..:::||.:||....|.||.|:||:..||....|.:
Zfish   840 GYRLPAPMGCPSAVNQLMLQCWMQDRSTRPRFVDIVNLLEKLLRNPE 886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 20/90 (22%)
PTKc_InsR_like 1364..1652 CDD:173625 105/302 (35%)
epha2aNP_571490.1 EphR_LBD_A2 27..202 CDD:198448
FN3 <321..>537 CDD:442628 38/185 (21%)
FN3 440..531 CDD:238020 24/106 (23%)
EphA2_TM 546..618 CDD:464211 21/77 (27%)
PTKc_EphR_A2 615..882 CDD:133194 103/291 (35%)
SAM_EPH-A2 909..978 CDD:188942
Blue background indicates that the domain is not in the aligned region.

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