Protein Alignment InR and ephb4a

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_571489.1
• Gene: ephb4a / 30688
• ZFINID: ZDB-GENE-990415-62
• Length: 987
• Species: Danio rerio
• Alignment Length: 994
• Identity: 232/994 - (23%)
• Similarity: 370/994 - (37%)
• Gaps: 241/994 - (24%)

  Fly   783 SKPKFFEKSDVGADSNGNR--------GSCGTAVLNVTLQSVGANSAMLNV-TTKVEIGEPQKPS 838
            |||::.|.|.:..::|..|        ||....|.:..::..||:...:.: .|.||.      |
Zfish    47 SKPEWEEVSGLDEENNSVRTYQICQADGSSSHCVRSKLIERRGASQVYVELFFTMVEC------S 105

  Fly   839 NATIVFKDPRAFIGFVFYH-------------MIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVL 890
            :.....:..:......:|.             |.:||   ||......|...:....:|..|..|
Zfish   106 SRNTHHRSCKETFNLYYYQSDTDDATATHPAWMENPY---TKVDTVAADFLLRKGGEKKVNVKTL 167

  Fly   891 SNLIPYTNYSYYV------RTMAISS---------ELTNAESDVKNFRTNPGRPSKVTEVVATAI 940
             .|.|.:...:|:      ..||:.|         .||.:.|...  .|.|  .|.|.|.|...:
Zfish   168 -RLGPLSKRGFYLAFQAQGACMALLSVRVFFKKCPALTRSLSVFP--ETVP--RSLVQEAVGQCV 227

  Fly   941 SDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDP 1005
            :::.         :|               .|:....:.:|.|   .....|.|.||
Zfish   228 ANAA---------QP---------------GPSPRPPKMFCGE---DGQWVDQPTTT-------- 257

  Fly  1006 LAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGS---------SDKSDG 1061
                |.|:.|. :.|..|.:.|....|:                 .|.||         .:...|
Zfish   258 ----CTCLPGF-EASHGELECRACPVGL-----------------FKMGSGTGPCSVCPENSQTG 300

  Fly  1062 AEGAAL------------DSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDA 1114
            ..|:|.            ||...|   .|.|....|...  |::                :||..
Zfish   301 ETGSAACVCRSGFYRALSDSADTP---CTRPPSSPRSPV--PQV----------------NDTSL 344

  Fly  1115 FFEKDDENTYKDEEDLSSNKQFYEVFAK----------------ELPPNQTHFVFEK-----LRH 1158
            ..|..:........|||     |.|..:                ...|:||.....:     ||.
Zfish   345 TLEWSEPLDSGGRSDLS-----YSVECRMCSTPGSPCTLCSDGVNYRPSQTGIQGRRVSIWGLRP 404

  Fly  1159 FTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESP 1223
            .|.|:..|:|         |...|.:.......:|:..||...     |..|...|..:..|||.
Zfish   405 HTTYSFTVMA---------LNGVSAQSQQGPAGETINITTSPN-----VPVLVSGLRKSTATESS 455

  Fly  1224 VRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL-YSFRVRANS 1287
            :.:.|..|...:..|:.|::.| .:|....||..| ...:.|.....|..|.... |..:|||.:
Zfish   456 LTLYWNTPTQSHYRILQYQIRY-CEKERGSEENSC-HYMESNNNEVVLSDLRRATQYEVQVRART 518

  Fly  1288 IAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLA---FLIVSLFGYVCYLHKRKVPSNDLHMNTE 1349
            .||||.|.:....:..|....:.....:.||.:|   .|::.:.|...|..:::....|..: ::
Zfish   519 FAGYGSFGKAILFRTLPDEDDSSSPLLVTGILIAMGMLLLIIVIGAAIYCIRKQNNYKDPEL-SD 582

  Fly  1350 VNPFYASMQ----YI-PDDWEVLRENIIQLAP------------LGQGSFGMVYEGILKSFPPNG 1397
            .|..|...|    || |..:|...|.:.:.|.            :|.|.||.|..|.|:.  |..
Zfish   583 KNGQYLMGQGVKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLRI--PGK 645

  Fly  1398 VDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSY 1462
            .:...||||:....||::|.:||:|||:|.:|...:::.|.|:.:...|.:::.|.|:.|.|.|:
Zfish   646 KENYVAIKTLKGGYTDKQRRDFLAEASIMGQFQHPNIIHLEGIITASCPVMILTEFMENGALDSF 710

  Fly  1463 LRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMV 1527
            ||.      ::...|.:..:|               |...||.||.||:...:|||||||||.:|
Zfish   711 LRL------NDGQFTPIQLVG---------------MLRGIASGMKYLSEMSYVHRDLAARNILV 754

  Fly  1528 ADDLTVKIGDFGMTRDIYETD---YYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEM 1589
            ..:|..|:.|||::|.:.|..   .|.....|.:|:||..||::....::.||||:|:|:|:||:
Zfish   755 NSNLVCKVSDFGLSRFLQENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTCASDVWSYGIVMWEV 819

  Fly  1590 ATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQC 1654
            .:...:||..:||:.|:..:.....:..|.:|..:||:||..||....:|||.|.:|::.|:...
Zfish   820 MSFGERPYWDMSNQDVINAIEQDYRLPPPPDCSTYLHQLMLDCWQKERTARPRFANIVSALDKLI 884

  Fly  1655 PNSQFKEVSFYHSEAGLQH 1673
            .|....:::.... ||..|
Zfish   885 RNPASLKITAQEG-AGPSH 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628	38/209 (18%)
		FN3	1224..1302	CDD:238020	21/78 (27%)
		PTKc_InsR_like	1364..1652	CDD:173625	96/302 (32%)
ephb4a	NP_571489.1	EphR_LBD	26..199	CDD:470656	32/161 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	319..340		7/41 (17%)
		fn3	339..418	CDD:394996	18/108 (17%)
		FN3	440..533	CDD:238020	26/94 (28%)
		EphA2_TM	547..618	CDD:464211	16/71 (23%)
		PTKc_EphR_B	616..884	CDD:173638	93/290 (32%)
		SAM_EPH-B4	914..980	CDD:188953