DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Ror2

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:XP_017455997.1 Gene:Ror2 / 306782 RGDID:1305275 Length:950 Species:Rattus norvegicus


Alignment Length:1067 Identity:239/1067 - (22%)
Similarity:374/1067 - (35%) Gaps:320/1067 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   940 ISDSKINVTWSYL---DKPYGVLTRYFIK-AKLINRPTRNNNRD---YC-----TEPLVKAMEND 992
            :.||:...|...|   |.|...|..||:. .:.:|..|....:.   :|     ..|.|:.::||
  Rat    42 VEDSEAIDTLGQLDGPDSPLPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKND 106

  Fly   993 LPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSS- 1056
            .|.....:::.                                            |||::.||. 
  Rat   107 APVVQEPRRVI--------------------------------------------IRKTEYGSRL 127

  Fly  1057 -----DKSDGAEGAALDSNAIPNGGAT-----------NPSRRRRDVALEPELDDVE-------- 1097
                 |.:|......:.:|.:....||           :|:...:|       ||.|        
  Rat   128 RIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTHSPNHNFQD-------DDQEDGFCQPYR 185

  Fly  1098 GSVLLRHVRSITDDTDAF-FEKDDENTYK-------DEEDLSSNKQFYEVFAKELPPNQTHFVFE 1154
            |....|.:.:.|...|:. .:.:.||...       ....||.....:.:      |:..|||| 
  Rat   186 GIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAI------PSFCHFVF- 243

  Fly  1155 KLRHFTRYAIFVVACREEIPSEKLRDTS--FKKSLCSDYDTVFQTTKRKKFADIVMDLKV-DLEH 1216
                    .:.....|...|.|..||..  .:..||....|:.::...     |:|.|:: ..|.
  Rat   244 --------PLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPL-----ILMRLQLPKCEA 295

  Fly  1217 ANNTESPVRVRWTPPVDPNGEIVTYEVAYK-----------------------LQKPDQVEEKKC 1258
            ....|||..........|...:..|...|.                       ||.|    ....
  Rat   296 LPMPESPDAANCMRIGIPAERLGRYHQCYNGSGTDYRGMASTTKSGHQCQPWALQHP----HSHR 356

  Fly  1259 IPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVE----PPPS------YAKVFF 1313
            :.:.:|.:..|       |....|.....:.|...||:.::::||    ||.|      ...::.
  Rat   357 LSSTEFPELGG-------GHAYCRNPGGQMEGPWCFTQNKNVRVELCDVPPCSPRDGSKMGILYI 414

  Fly  1314 WLLGIGLAFLIVSLFGYVCYL-HKRKV-------------PSNDLHMNTEVNPFYASMQYIPDDW 1364
            .:..|.:..:|..||..||.. :|:|.             ||.|:.|........|.::      
  Rat   415 LVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLISQHKQAKLK------ 473

  Fly  1365 EVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEF 1429
            |:....:..:..||:..||.||:|.|....|....:..||||:.:.|....|..|..||.:....
  Rat   474 EISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQVVAIKTLKDKAEGPLREEFRQEAMLRARL 538

  Fly  1430 DTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGN------- 1487
            ...::|.||||.::.||..:|......|||..:|....|.          :.:|.|.:       
  Rat   539 QHPNIVCLLGVVTKDQPLSMVFSYCCHGDLHEFLVMRSPH----------SDVGSTDDDRTVKSA 593

  Fly  1488 VQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRK 1552
            ::||.:   ..:..:||.||.:|::...||:|||.||.:|.|.|.|:|.|.|:.|::|..|||:.
  Rat   594 LEPPDF---VHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKL 655

  Fly  1553 GTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMER 1617
            ....|||:|||.||::..|.:|..||::|:||||||:.:...|||.|.||:.|:..:....|:..
  Rat   656 MGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPC 720

  Fly  1618 PENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERN 1682
            |::||.:::.||..||:...|.||.|.||...|.      .:..:|.|:|.|             
  Rat   721 PDDCPAWVYALMIECWNEFPSGRPRFKDIHGRLR------SWGNLSNYNSSA------------- 766

  Fly  1683 QLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIA----MVDDQGSHLPFSLP 1743
                              |...|:      :..|.|||...|.|.::    |...|.:. ||..|
  Rat   767 ------------------QTSGAS------NTTQTSSLSTSPVSNVSNARYMAPKQKAQ-PFPQP 806

  Fly  1744 -----SGFIASSTPDGQT-VMATAFQNIPAAQGDISATYVVPDADALDGDRGYEIYDPS------ 1796
                 .|.|....|..|. :....:|.:||                      |..|.|:      
  Rat   807 QFIPMKGQIRPLVPPAQLYIPVNGYQPVPA----------------------YGAYLPNFYPVQI 849

  Fly  1797 ----------PKCAELPTSR---SGSTGGGKLS--------GEQHLLPRKGRQPTIMSSSMPDDV 1840
                      |:....|:|.   ||||..|.::        .::..|..:|.:..   .:||:||
  Rat   850 PMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSVADRAALLSEGTEDV---QNMPEDV 911

  Fly  1841 IGGSSLQ----------PSTASAGSSN 1857
             ..|.:|          |.|...|.|:
  Rat   912 -AQSPVQEAEEEEEGSVPETELLGDSD 937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 8/26 (31%)
FN3 1224..1302 CDD:238020 13/100 (13%)
PTKc_InsR_like 1364..1652 CDD:173625 101/294 (34%)
Ror2XP_017455997.1 I-set 71..159 CDD:400151 18/131 (14%)
Ig strand B 86..90 CDD:409353 0/3 (0%)
Ig strand C 99..103 CDD:409353 1/3 (33%)
Ig strand E 125..129 CDD:409353 1/3 (33%)
Ig strand F 139..144 CDD:409353 0/4 (0%)
Ig strand G 152..155 CDD:409353 1/2 (50%)
CRD_TK_ROR2 177..316 CDD:143577 30/158 (19%)
KR 321..402 CDD:214527 15/91 (16%)
Protein Kinases, catalytic domain 473..756 CDD:473864 101/307 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.