DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Lmtk2

DIOPT Version :9

Sequence 1:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:XP_038945280.1 Gene:Lmtk2 / 304286 RGDID:1598332 Length:1631 Species:Rattus norvegicus


Alignment Length:1077 Identity:243/1077 - (22%)
Similarity:371/1077 - (34%) Gaps:329/1077 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1293 DFTEVE-----HIKVEPP----PSY---AKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLH 1345
            ||.|.|     .|...||    ||.   |:||                       ...||:..|.
  Rat    75 DFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVF-----------------------TLSVPNISLP 116

  Fly  1346 MNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNEN 1410
            ..::   |.:|::.:..  :|.|.::..:..:|.|.||.|..|  :::....|.| ..:|.:..:
  Rat   117 APSQ---FQSSVEGLKS--QVARHSLNYIQEIGNGWFGKVLLG--ETYTGTSVTR-VIVKELKVS 173

  Fly  1411 ATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAM 1475
            |:.:|:..||:...........:|::.:|.|....|.|:|.|....||||:||...:...|.|:.
  Rat   174 ASPKEQDTFLNSGEPYYILQHPNVLQCVGQCVEAIPYLLVFEFCDLGDLKAYLHNEQEHVRSESQ 238

  Fly  1476 MTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGM 1540
            ...|.|                 ||.|||.|:|.:....|:|.|||.|||.:..||.||:||:|:
  Rat   239 TMLLQR-----------------MACEIAAGLAAMHKLHFLHSDLALRNCYLTSDLNVKVGDYGI 286

  Fly  1541 TRDIYETDYYRKGTKGLLPVRWMPPE---SLRDGVYSS----ASDVFSFGVVLWEMATLAAQPYQ 1598
            ....|:.||.....|.:.|:||..||   |.:|.:.::    .|:::|.||.|||:...|||||.
  Rat   287 GFSRYKEDYIETDDKKIFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFNNAAQPYA 351

  Fly  1599 GLSNEQVLRYVIDGGVMERPE---NCP--DFLHKLMQRCWHHRSSARPSFLDI---IAYLEPQCP 1655
            .||:..||..||....|:.|:   ..|  :..::::|.|| .....||:..|:   :.||..|  
  Rat   352 NLSDLDVLNQVIRERDMKLPKPQLELPYSERWYEVLQFCW-LSPDKRPAAEDVHRLLTYLRMQ-- 413

  Fly  1656 NSQFKEVSFYHSEAGLQHREKERKERNQ-----LDAFAAVPLDQDLQDREQQEDAT-TPLRMG-- 1712
            :.:..||.|......|:.....|...:.     ||.||     :|...||.:|..| |....|  
  Rat   414 SQRDSEVDFEQQWTALKPNANSRDPSSSAAFPILDHFA-----RDRLGREMEEVLTVTETSQGLS 473

  Fly  1713 -DY-QQNSSLDQPPESPIAMVDDQGSHLPFSLPSGFIASSTPD---GQTVMATAFQNIPAAQGDI 1772
             :| .:.:..|...|......|:..|:.....|.....:|..|   |:       |:....:|.:
  Rat   474 FEYVWEAAKHDHFDEQGRGHPDEALSYSSMFFPVEVFENSLSDPGPGK-------QDGSGQEGPL 531

  Fly  1773 SATYVVP--DADALDGDRGYEI-------------YDPSPKCAELPTSRSGSTGGGKLSGEQHLL 1822
            .|..|||  ||..|.....|.|             |.|:....|:.....|.|....|:..:.|:
  Rat   532 RAPGVVPVFDAHNLSVGSDYYIQLEEKSSSSLGLEYPPALLTTEVDNPEKGGTDAPHLTAFKTLV 596

  Fly  1823 PRKGRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSHTG------------------------ 1863
               ..:|     |..:|....|:......||..|:|:|..|                        
  Rat   597 ---SEEP-----SAEEDFFQSSARPKEANSAEDSHAASIPGSPFNIFSDLDKADDLPSHQKIFDL 653

  Fly  1864 ---------------RPSL--KKTVADSVRNK----------------------------ANFI- 1882
                           .|||  .|....|.|.|                            .||: 
  Rat   654 MELNGVQADFKPAILSPSLDGPKDTCQSEREKPHDQDPLCFPESPVHQDCFDPLSVQELSENFLF 718

  Fly  1883 --NRHLFNHKRTG-----------SNASHKSNASNAP---STSSNTNLTSH----PVAMGNLGTI 1927
              .::|......|           .:|...|....:|   |.||...|..|    |.:..|:...
  Rat   719 LQEKNLLKGSLPGKGRVNDLQTELKDAGFISEMLESPRRGSVSSGLELLEHTLDFPSSQENMSGQ 783

  Fly  1928 ESGGSG-------------SAGSYTGTP---------RFYT------------------------ 1946
            ..|..|             :.||..|.|         :.:|                        
  Rat   784 NKGTGGTPQGATSPQASPLTEGSPNGPPDSVLKSGETKPFTGVSVPENSVCLDLSPDPVTGPVEI 848

  Fly  1947 PSA---TPGGGSG---------MAISDNPNYR--LLDESIASEQATILTTSSPNPNYEMMHPPTS 1997
            |:|   .|.||.|         .|:  ||..|  :|:..|.::.:  :.|..|....::.:.|.|
  Rat   849 PAADAKAPDGGDGPPEVTCQSKEAL--NPTKRDPILENEITAQGS--METCLPESGQDLQNQPFS 909

  Fly  1998 LVSTNPNYMPMNETPVQMAGVTISHNPNYQ--PMQAPLNARQSQSSSDED-------------NE 2047
            ....:.:.:..|...|:..     :..||:  |..|.|.:..|..|:.:|             :|
  Rat   910 EDPLSGSILEKNSEAVETL-----NQLNYKAAPKDAALASALSSDSTSQDSLLEDSLSTPIPTSE 969

  Fly  2048 QEEDDEDEDDDVDDEHVEHIKMERMPLSRPRQRALPSKTQPPRSRSVSQTRKSPT---------N 2103
            |..:..|..|.||   |....:|.:....|::...|.|  |..|...::..:||.         .
  Rat   970 QSVETPDSLDSVD---VHAALLESLGSHTPQKLLPPDK--PADSGYETENLESPEWTLHPAPEGT 1029

  Fly  2104 PNSGIGATGAGNRSNLLKENWLRPASTPRPPPPNGFI 2140
            .:|...|.|..:.|:|               |||..|
  Rat  1030 ADSDTAAAGDSSHSSL---------------PPNPVI 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382
Furin-like 512..645 CDD:279142
FU 545..592 CDD:238021
Recep_L_domain 663..781 CDD:279382
FN3 1224..1302 CDD:238020 5/13 (38%)
PTKc_InsR_like 1364..1652 CDD:173625 94/302 (31%)
Pkinase_Tyr 1371..1650 CDD:285015 90/293 (31%)
Lmtk2XP_038945280.1 PTKc_Aatyk2 139..409 CDD:270669 90/290 (31%)
PHA03247 <1004..1383 CDD:223021 14/65 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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