DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and EPHA10

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001092909.1 Gene:EPHA10 / 284656 HGNCID:19987 Length:1008 Species:Homo sapiens


Alignment Length:613 Identity:152/613 - (24%)
Similarity:227/613 - (37%) Gaps:214/613 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1213 DLEHANNTESP--VRVRWTPPVDPNGEIVTYEVAYKL-------QKPDQVEEKKCIPAADF---- 1264
            ||:: :.:.||  :|:||.||.|..|.   .:|.|.|       :.|....| .|.|...|    
Human   343 DLQY-SLSRSPLVLRLRWLPPADSGGR---SDVTYSLLCLRCGREGPAGACE-PCGPRVAFLPRQ 402

  Fly  1265 ---NQTAGYLIKLNEGL-YSFRVRA-NSIAG--------YGDFT------------EVEHIKVEP 1304
               .:.|..|:.|..|. |:.||.| |.::|        |...|            |:...:|||
Human   403 AGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVEP 467

  Fly  1305 ----------------------------------------------------PPSYAKVF----- 1312
                                                                .|:...||     
Human   468 QSVSLSWREPIPAGAPGANDTEYEIRYYEKGQSEQTYSMVKTGAPTVTVTNLKPATRYVFQIRAA 532

  Fly  1313 ----FW-------------------------------------LLGIGLAFLIVSLFGYVC---- 1332
                .|                                     ||.:|....:::::...|    
Human   533 SPGPSWEAQSFNPSIEVQTLGEAASGSRDQSPAIVVTVVTISALLVLGSVMSVLAIWRRPCSYGK 597

  Fly  1333 -----------YLHKRKVPSNDLHMNTEVNP-----------FYASMQYIPDDWEVLRENIIQLA 1375
                       |.| .|||:.    .|.::|           .:|.        |:..:::....
Human   598 GGGDAHDEEELYFH-FKVPTR----RTFLDPQSCGDLLQAVHLFAK--------ELDAKSVTLER 649

  Fly  1376 PLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGV 1440
            .||.|.||.:..|.|:.  |...:...|:..:.::|:|.:|..||:||..:.:||..|:|||.||
Human   650 SLGGGRFGELCCGCLQL--PGRQELLVAVHMLRDSASDSQRLGFLAEALTLGQFDHSHIVRLEGV 712

  Fly  1441 CSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIAD 1505
            .:||...::|.|.|..|.|..:||.|.                  |.:   ..|::..:...:|.
Human   713 VTRGSTLMIVTEYMSHGALDGFLRRHE------------------GQL---VAGQLMGLLPGLAS 756

  Fly  1506 GMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGM-TRDIYETDYYRKGTKGLLPVRWMPPESLR 1569
            .|.||:...:|||.||||:.:|:.||..||..||. .||..|..|  ....|..|..|..||:|:
Human   757 AMKYLSEMGYVHRGLAARHVLVSSDLVCKISGFGRGPRDRSEAVY--TTMSGRSPALWAAPETLQ 819

  Fly  1570 DGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWH 1634
            .|.:||||||:|||:::||:.....:||..:|.:.|::.|.||..:..|.|||:.||:||..||.
Human   820 FGHFSSASDVWSFGIIMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPNLLHRLMLDCWQ 884

  Fly  1635 HRSSARPSFLDIIAYLE--------PQC 1654
            .....||.|..|.:.|.        |:|
Human   885 KDPGERPRFSQIHSILSKMVQDPEPPKC 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 28/113 (25%)
PTKc_InsR_like 1364..1652 CDD:173625 99/296 (33%)
EPHA10NP_001092909.1 EphR_LBD_A10 35..210 CDD:198455
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..342
fn3 339..431 CDD:394996 28/92 (30%)
FN3 451..531 CDD:214495 7/79 (9%)
EphA2_TM 569..642 CDD:464211 13/85 (15%)
PTKc_EphR_A10 639..904 CDD:133195 99/289 (34%)
SAM_superfamily 929..998 CDD:472832
Blue background indicates that the domain is not in the aligned region.

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