DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and Alk

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001162572.1 Gene:Alk / 266802 RGDID:628622 Length:1617 Species:Rattus norvegicus


Alignment Length:608 Identity:176/608 - (28%)
Similarity:274/608 - (45%) Gaps:124/608 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1302 VEPPPSYAKVFFWLLGIGLAFLIVSL---FGYVCYLHKRK----------VPSNDLHMN------ 1347
            |.|.|........:|.:..:.|:.:|   |..:..:::||          :.|.:..::      
  Rat  1027 VSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTST 1091

  Fly  1348 --TEVNP---FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTV 1407
              |:.||   |......|.|..||.|:||..:..||.|:||.||||.:...|.:....:.|:||:
  Rat  1092 IMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL 1156

  Fly  1408 NENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERD 1472
            .|..::::..:||.||.::.:|:..::||.:||..:..|..:::|||..|||||:||..||....
  Rat  1157 PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQ 1221

  Fly  1473 EAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLT----- 1532
            ...:..|:               :..:|.:||.|..||....|:|||:|||||:    ||     
  Rat  1222 PTSLAMLD---------------LLHVARDIACGCQYLEENHFIHRDIAARNCL----LTCPGAG 1267

  Fly  1533 --VKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQ 1595
              .|||||||.||||...|||||...:|||:|||||:..:|:::|.:|.:||||:|||:.:|...
  Rat  1268 RIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYM 1332

  Fly  1596 PYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE-----PQCP 1655
            ||...||::||.:|..||.|:.|:|||..::::|.:||.|:...||:|..|:..:|     |...
  Rat  1333 PYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVI 1397

  Fly  1656 NSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSL 1720
            |:...      .|.|....|:|:......|.....||....|..:.:|.::.|       |.|:|
  Rat  1398 NTALP------IEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQSAKHEEASSAP-------QPSAL 1449

  Fly  1721 DQPPESPIAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDISATYVVPDADALD 1785
            ..|  .|:.       ..|....:|..|...|.|           .|.:|.::..:..|      
  Rat  1450 AAP--GPLV-------KKPSGAGAGAGAGPVPRG-----------AADRGHVNMAFSQP------ 1488

  Fly  1786 GDRGYEIYDPSPKCAELPTSRS----------GSTGGGKLSGEQHLLPRKGRQPTIMSSSMPDDV 1840
                    :|.|:..:.|.||:          ||....|.:.:.|  |..|.:|...:.:.....
  Rat  1489 --------NPPPELHKGPGSRNKPTSLWNPTYGSWFTEKPAKKTH--PPPGAEPQARAGAAEGGW 1543

  Fly  1841 IGGSS----------LQPSTASA 1853
            .|..:          |:||..||
  Rat  1544 TGPGAGPRRAEAALLLEPSALSA 1566

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 176/608 (29%)
PTKc_InsR_like 1364..1652 CDD:173625 117/299 (39%)
AlkNP_001162572.1 MAM 270..428 CDD:99706
MAM 484..639 CDD:459878
FXa_inhibition 991..1025 CDD:464251
PTKc_ALK_LTK 1113..1389 CDD:270632 116/294 (39%)
PRK12323 <1407..>1576 CDD:481241 39/203 (19%)
Blue background indicates that the domain is not in the aligned region.

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