DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Ror2

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_038874.3 Gene:Ror2 / 26564 MGIID:1347521 Length:944 Species:Mus musculus


Alignment Length:1027 Identity:230/1027 - (22%)
Similarity:362/1027 - (35%) Gaps:302/1027 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   928 RPSKV----------------TEVVATAISDSKINVTWSY---LDKPYGVLTRYFIK-AKLINRP 972
            |||:|                |...|..:.||:...|...   .|.|...|..||:. .:.:|..
Mouse     7 RPSRVPLCARAVWTAAALLLWTPWTAGEVEDSEAIDTLGQPDGPDSPLPTLKGYFLNFLEPVNNI 71

  Fly   973 TRNNNRD---YC-----TEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKV 1029
            |....:.   :|     ..|.|:.::||.|.....:::.                          
Mouse    72 TIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVI-------------------------- 110

  Fly  1030 QAGMEFENALQNFIFVPNIRKSKNGSS------DKSDGAEGAALDSNAIPNGGAT---------- 1078
                              |||::.||.      |.:|......:.:|.:....||          
Mouse   111 ------------------IRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPT 157

  Fly  1079 -NPSRRRRDVALEPELDDVE--------GSVLLRHVRSITDDTDAF-FEKDDENTYKDE-EDLSS 1132
             :|:...:|       ||.|        |....|.:.:.|...|:. .:.:.||..... ..:.:
Mouse   158 HSPNHNFQD-------DDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGT 215

  Fly  1133 NKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTS--FKKSLCSDYDTVF 1195
            :.|..:..::...|:..||||         .:.....|...|.|..||..  .:..||....|:.
Mouse   216 STQLSDQCSQFAIPSFCHFVF---------PLCDARSRAPKPRELCRDECEVLENDLCRQEYTIA 271

  Fly  1196 QTTKRKKFADIVMDLKV-DLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYK------------- 1246
            ::...     |:|.|:: ..|.....|||..........|...:..|...|.             
Mouse   272 RSNPL-----ILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGADYRGMASTT 331

  Fly  1247 ----------LQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIK 1301
                      ||.|    ....:.:.:|.:..|       |....|.....:.|...||:.::::
Mouse   332 KSGHQCQPWALQHP----HSHRLSSTEFPELGG-------GHAYCRNPGGQMEGPWCFTQNKNVR 385

  Fly  1302 VE----PPPS------YAKVFFWLLGIGLAFLIVSLFGYVCYL-HKRKV-------------PSN 1342
            ||    ||.|      ...::..:..|.:..:|..||..||.. :|:|.             ||.
Mouse   386 VELCDVPPCSPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQ 450

  Fly  1343 DLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTV 1407
            |:.|........|.::      |:....:..:..||:..||.||:|.|....|....:..||||:
Mouse   451 DMEMPLISQHKQAKLK------EISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEPTQAVAIKTL 509

  Fly  1408 NENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERD 1472
            .:.|....|..|..||.:.......::|.||||.::.||..::......|||..:|....|.   
Mouse   510 KDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH--- 571

  Fly  1473 EAMMTYLNRIGVTGN-------VQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADD 1530
                   :.:|.|.:       ::||.:   ..:..:||.||.:|::...||:|||.||.:|.|.
Mouse   572 -------SDVGSTDDDRTVKSALEPPDF---VHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDK 626

  Fly  1531 LTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQ 1595
            |.|:|.|.|:.|::|..|||:.....|||:|||.||::..|.:|..||::|:||||||:.:...|
Mouse   627 LNVRISDLGLFREVYSADYYKLMGNSLLPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQ 691

  Fly  1596 PYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFK 1660
            ||.|.||:.|:..:....|:..|::||.:::.||..||:...|.||.|.||.:.|.      .:.
Mouse   692 PYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR------SWG 750

  Fly  1661 EVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPE 1725
            .:|.|:|.|                               |...|:      :..|.|||...|.
Mouse   751 NLSNYNSSA-------------------------------QTSGAS------NTTQTSSLSTSPV 778

  Fly  1726 SPIA----MVDDQGSHLPFSLP-----SGFIASSTPDGQT-VMATAFQNIPAAQGDISATYVVPD 1780
            |.::    |...|.:. ||..|     .|.|....|..|. :....:|.:||             
Mouse   779 SNVSNARYMAPKQKAQ-PFPQPQFIPMKGQIRPLVPPAQLYIPVNGYQPVPA------------- 829

  Fly  1781 ADALDGDRGYEIYDPS----------------PKCAELPTSR---SGSTGGG 1813
                     |..|.|:                |:....|:|.   ||||..|
Mouse   830 ---------YGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTG 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 13/54 (24%)
FN3 1224..1302 CDD:238020 13/100 (13%)
PTKc_InsR_like 1364..1652 CDD:173625 100/294 (34%)
Ror2NP_038874.3 I-set 64..152 CDD:400151 18/131 (14%)
Ig strand B 79..83 CDD:409570 0/3 (0%)
Ig strand C 92..96 CDD:409570 1/3 (33%)
Ig strand E 118..122 CDD:409570 1/3 (33%)
Ig strand F 132..137 CDD:409570 0/4 (0%)
Ig strand G 145..148 CDD:409570 1/2 (50%)
CRD_TK_ROR2 170..309 CDD:143577 29/152 (19%)
KR 314..395 CDD:214527 15/91 (16%)
Protein Kinases, catalytic domain 466..749 CDD:473864 100/307 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..779 9/58 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 850..879 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 898..929
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.