Protein Alignment InR and Ror1

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_038873.2
• Gene: Ror1 / 26563
• MGIID: 1347520
• Length: 937
• Species: Mus musculus
• Alignment Length: 1082
• Identity: 263/1082 - (24%)
• Similarity: 393/1082 - (36%)
• Gaps: 311/1082 - (28%)

  Fly   906 MAISSEL-------TNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYF 963
            :::|:||       |::|.|..::.|                           ||:|...:|...
Mouse    34 LSVSAELVPTSSWNTSSEIDKGSYLT---------------------------LDEPMNNITTSL 71

  Fly   964 -----IKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKIS------------------DP 1005
                 :..|:...|          .|.::..:||.|.....::||                  |.
Mouse    72 GQTAELHCKVSGNP----------PPSIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDT 126

  Fly  1006 LAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSN 1070
            ....|....|.|..|:         .|:.|..      |.|....|. ||||:.:
Mouse   127 GYFQCVATNGKKVVST---------TGVLFVK------FGPPPTASP-GSSDEYE---------- 165

  Fly  1071 AIPNGGATNPSR--------RRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDE 1127
               ..|...|.|        ..|.|.:|.          |.....|.:...|.|.....:::
Mouse   166 ---EDGFCQPYRGIACARFIGNRTVYMES----------LHMQGEIENQITAAFTMIGTSSH--- 214

  Fly  1128 EDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYD 1192
              ||.....:.:      |:..|:.|.             .|.|.....|.||      ||.|..
Mouse   215 --LSDKCSQFAI------PSLCHYAFP-------------YCDETSSVPKPRD------LCRDEC 252

  Fly  1193 TVFQTTKRKK---FAD----IVMDLKV-DLEHANNTESP-----VRVRWTPPVDP--------NG 1236
            .|.:....:.   ||.    |:|.||: :.|.....|||     :|: ..|..||        |.
Mouse   253 EVLENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRI-GIPMADPINKNHKCYNS 316

  Fly  1237 EIVTYEVAYKLQKPDQVEEKKCIPAADFNQ--------TAGYLIKLNEGLYSFRVRANSIAGYGD 1293
            ..|.|.....:.|    ..::|.|   :|.        ||....:||.|....|...|.......
Mouse   317 TGVDYRGTVSVTK----SGRQCQP---WNSQYPHTHSFTALRFPELNGGHSYCRNPGNQKEAPWC 374

  Fly  1294 FTEVEHIK---VEPPPSYAK----------VFFWLLGIGLAFLIVSLFGYVCYLHK--------- 1336
            ||..|:.|   .:.|...:|          ::..:..:.:...|..||.::|....
Mouse   375 FTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAFLFFFICVCRNNQKSSSPPV 439

  Fly  1337 RKVPSNDLHMNTEVNPFYASMQYIPDD--WEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVD 1399
            ::.|......|.|::...|   |.|..  .|:....:..:..||:.:||.:|:|.|  :.| |:|
Mouse   440 QRQPKPVRGQNVEMSMLNA---YKPKSKAKELPLSAVRFMEELGECTFGKIYKGHL--YLP-GMD 498

  Fly  1400 RE--CAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSY 1462
            ..  .||||:.:....::.|.|..|||:|.|....::|.|||..::.||..::.|.|.:|||..:
Mouse   499 HAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEF 563

  Fly  1463 LRAHRP-------EERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDL 1520
            |....|       .:.|..:.:.|:            :|....:||:||.||.||::..|||:||
Mouse   564 LIMRSPHSDVGCSSDEDGTVKSSLD------------HGDFLHIAIQIAAGMEYLSSHFFVHKDL 616

  Fly  1521 AARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVV 1585
            ||||.::.:.|.|||.|.|::|:||..||||..:|..||:||||||::..|.:||.||::|||||
Mouse   617 AARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVV 681

  Fly  1586 LWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYL 1650
            |||:.:...|||.|.||::|:..|....::...|:||..::.||..||:...|.||.|.||...|
Mouse   682 LWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRL 746

  Fly  1651 EPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQ 1715
                           .|..||                            .....:|||.......
Mouse   747 ---------------RSWEGL----------------------------SSHTSSTTPSGGNATT 768

  Fly  1716 QNSSLDQPPES-------PIAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDIS 1773
            |.:||...|.|       |..|...||. .|....:|||..:.|..|..:......||.......
Mouse   769 QTTSLSASPVSNLSNPRFPNYMFPSQGI-TPQGQIAGFIGPAIPQNQRFIPINGYPIPPGYAAFP 832

  Fly  1774 ATYVVPDADALDGDRGYEIYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPRKGRQ-----PTIMS 1833
            |.:..|     .|......:.|.|| :..|:|.||||..|.::.    ||..|..     |.:..
Mouse   833 AAHYQP-----AGPPRVIQHCPPPK-SRSPSSASGSTSTGHVAS----LPSSGSNQEANVPLLPH 887

  Fly  1834 SSMPD-------DVIGGSSLQP------STASAGSSNASSHT 1862
            .|:|:       .|.|..|.:|      .::..|.|:...||
Mouse   888 MSIPNHPGGMGITVFGNKSQKPYKIDSKQSSLLGDSHIHGHT 929

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628	11/69 (16%)
		FN3	1224..1302	CDD:238020	22/96 (23%)
		PTKc_InsR_like	1364..1652	CDD:173625	112/296 (38%)
Ror1	NP_038873.2	I-set	63..148	CDD:400151	16/103 (16%)
		Ig strand B	75..79	CDD:409353	0/3 (0%)
		Ig strand C	88..92	CDD:409353	0/3 (0%)
		Ig strand E	114..118	CDD:409353	0/3 (0%)
		Ig strand F	128..133	CDD:409353	1/4 (25%)
		Ig strand G	139..142	CDD:409353	0/2 (0%)
		CRD_TK_ROR1	166..307	CDD:143576	37/181 (20%)
		KR	311..393	CDD:214527	19/88 (22%)
		PTKc_Ror1	467..749	CDD:270672	112/311 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	753..778		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	840..890		15/54 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	916..937		4/14 (29%)