DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Kdr

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_037194.2 Gene:Kdr / 25589 RGDID:2965 Length:1343 Species:Rattus norvegicus


Alignment Length:1363 Identity:291/1363 - (21%)
Similarity:495/1363 - (36%) Gaps:423/1363 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   731 ADKYAL-YVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVG 794
            :|::.: |:.:|:        |:||.|...|...:.|..||.              ::.||..| 
  Rat   130 SDEHGIVYITENK--------NKTVVIPCRGSISNLNVSLCA--------------RYPEKRFV- 171

  Fly   795 ADSNGNRGS---------------------CGTAVLNVTLQSV---------------------- 816
              .:|||.|                     |...:.:.|.||:                      
  Rat   172 --PDGNRISWDSEKGFTIPSYMISYAGMVFCEAKINDETYQSIMYIVLVVGYRIYDVVLSPPHEI 234

  Fly   817 ---GANSAMLNVTTKVEIG---------EPQKPSNATIVFKDPRAFIG-----FVFYHMIDPYGN 864
               .....:||.|.:.|:.         ...|..:..||.:|.::..|     |:....||   :
  Rat   235 ELSAGEKLVLNCTARTELNVGLDFSWQFPSSKHQHKKIVNRDVKSLPGTVAKMFLSTLTID---S 296

  Fly   865 STKSSDDPCDDRWKVSSPEKSGVMVLSNLI-------PYTNYSYYVRTM---AISSE-------L 912
            .|||      |:.:.:....||:|...|..       |:..:...::::   .:.|:       |
  Rat   297 VTKS------DQGEYTCTAYSGLMTKKNKTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYL 355

  Fly   913 TNAESDVKNFRTNPGRP--SKVTEVVATAISDSKI------NVTWSYLDKPYGVLTRYFIKAKLI 969
            :....|:|.:|.  |||  |..|.:|...::..::      |.| ..|..|..:..:..:.:.::
  Rat   356 SYPAPDIKWYRN--GRPIESNYTMIVGDELTIMEVSERDAGNYT-VILTNPISMEKQSHMVSLVV 417

  Fly   970 NRPTRNNNRDYCTEPLVKAMEN----DLPATTPTKKISDPL-----------AGDCKCVEGSKKT 1019
            |.|.:...:     .|:..|::    .:...|.|...:.||           |...:..:.:..|
  Rat   418 NVPPQIGEK-----ALISPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPSQTNPYT 477

  Fly  1020 SSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAAL-DSNAIPNGGATNPSRR 1083
            ..:....:..|.|.:.|.....:..:..  |:|..|:.....|..:|| ...||...|     |.
  Rat   478 CKEWRHVKDFQGGNKIEVTKNQYALIEG--KNKTVSTLVIQAANVSALYKCEAINKAG-----RG 535

  Fly  1084 RRDVALE----PELDDVEGSVLLRHVRSITDDTD----AFFEKDDENTYKDEEDLSSNKQFYEV- 1139
            .|.::..    ||:.          |:..|..|:    :.....|.||::       |..:|:: 
  Rat   536 ERVISFHVIRGPEIT----------VQPATQPTEQESVSLLCTADRNTFE-------NLTWYKLG 583

  Fly  1140 -------FAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQT 1197
                   ..:.|.|                     .|:......||..|.|..|........||.
  Rat   584 SQATSVHMGESLTP---------------------VCKNLDALWKLNGTVFSNSTNDILIVAFQN 627

  Fly  1198 TKRKKFADIV---MDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQ-------KP-- 1250
            ...:...:.|   .|.|....|....:..:..|..|.:..|.|..|..:...::       .|  
  Rat   628 ASLQDQGNYVCSAQDKKTKKRHCLVKQLVILERMAPMITGNLENQTTTIGETIEVVCPTSGNPTP 692

  Fly  1251 --------DQVEEKKCIPAADFNQ--TAGYLIKLNEGLYSFR-------VRANS---IAGYGDFT 1295
                    :.:.|...|...|.|:  |...:.|.:.|||:.:       .||.:   |.|..:.|
  Rat   693 LITWFKDNETLVEDSGIVLKDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKT 757

  Fly  1296 EVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSL------------FGYVCYLHKRKVPSNDLHMNT 1348
            .:|.| :....:...:|||||      |::.|            .||:           .:.|:.
  Rat   758 NLEVI-ILVGTAVIAMFFWLL------LVIVLRTVKRANEGELKTGYL-----------SIVMDP 804

  Fly  1349 EVNPFYASMQYIPDD---WEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTV--- 1407
            :..|.....:.:|.|   ||..|:.:....|||:|:||.|.|.  .:|   |:|:....|||   
  Rat   805 DELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEA--DAF---GIDKTATCKTVAVK 864

  Fly  1408 --NENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSR-GQPALVVMELMKKGDLKSYLRAHRP 1468
              .|.||..|....:||..::.....: :||.|||.|:: |.|.:|::|..|.|:|.:|||..|.
  Rat   865 MLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRN 929

  Fly  1469 E--------ERDEAMMTYLNRIGV-----------------TGNVQPPTYGRIYQ---------- 1498
            |        .|..:...|:..:.|                 :|.|:..:...:.:          
  Rat   930 EFVPYKSKGARFRSGKDYVGELSVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKD 994

  Fly  1499 ---------MAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY-ETDYYRKG 1553
                     .:.::|.||.:||::|.:||||||||.::::...|||.|||:.|||| :.||.|||
  Rat   995 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG 1059

  Fly  1554 TKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMER 1617
             ...||::||.||::.|.||:..|||:||||:|||:.:|.|.||.|:. :|:..|.:.:|..|..
  Rat  1060 -DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRA 1123

  Fly  1618 PENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERN 1682
            |:.....:::.|..|||...:.||:|.:::.:|....             :|..|...|:     
  Rat  1124 PDYTTPEMYQTMLDCWHEDPNQRPAFSELVEHLGNLL-------------QANAQQDGKD----- 1170

  Fly  1683 QLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQG------------ 1735
                :..:|:.:.|   ..:||:...|              |.||::.::::.            
  Rat  1171 ----YIVLPMSETL---SMEEDSGLSL--------------PTSPVSCMEEEEVCDPKFHYDNTA 1214

  Fly  1736 --SHLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDISATYVVPDADALDGDRGYEIYDPSPK 1798
              ||        ::.:|....:.|....|::||..:.::.   |:||....|.  |..:.....|
  Rat  1215 GISH--------YLQNSKRKSRPVSVKTFEDIPLEEPEVK---VIPDDSQTDS--GMVLASEELK 1266

  Fly  1799 CAELPTSRSGSTGGGKLSGEQHLLPRKGRQPTIMSSSMPDDVIGGSSLQPSTASAGSSNASSH 1861
            ..|.....|.|.||        ::|.|.|:                    |.||.||:..|.:
  Rat  1267 TLEDRNKLSPSFGG--------MMPSKSRE--------------------SVASEGSNQTSGY 1301

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032 11/50 (22%)
FN3 791..>964 CDD:442628 45/257 (18%)
FN3 1224..1302 CDD:238020 22/106 (21%)
PTKc_InsR_like 1364..1652 CDD:173625 112/340 (33%)
KdrNP_037194.2 Ig 224..325 CDD:472250 20/109 (18%)
Ig strand B 242..246 CDD:409353 1/3 (33%)
Ig strand C 257..261 CDD:409353 0/3 (0%)
Ig strand E 290..294 CDD:409353 0/3 (0%)
Ig strand F 304..309 CDD:409353 0/4 (0%)
Ig strand G 317..320 CDD:409353 1/2 (50%)
Ig 329..417 CDD:472250 15/90 (17%)
Ig strand B 348..352 CDD:409353 0/3 (0%)
Ig strand C 361..365 CDD:409353 2/3 (67%)
Ig strand E 381..385 CDD:409353 0/3 (0%)
Ig strand F 395..400 CDD:409353 2/5 (40%)
Ig strand G 410..413 CDD:409353 0/2 (0%)
Ig_3 547..640 CDD:464046 21/130 (16%)
I-set 663..740 CDD:400151 14/76 (18%)
Ig strand B 680..684 CDD:409353 0/3 (0%)
Ig strand C 693..697 CDD:409353 0/3 (0%)
Ig strand E 716..720 CDD:409353 0/3 (0%)
Ig strand F 730..735 CDD:409353 2/4 (50%)
VEGFR-2_TMD 755..789 CDD:375470 10/40 (25%)
PTKc_VEGFR2 822..1163 CDD:270681 112/359 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1267..1314 14/63 (22%)
Blue background indicates that the domain is not in the aligned region.

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