DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and Tyro3

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_058788.1 Gene:Tyro3 / 25232 RGDID:3923 Length:880 Species:Rattus norvegicus


Alignment Length:606 Identity:164/606 - (27%)
Similarity:264/606 - (43%) Gaps:157/606 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1216 HANNTESPVRVRWTP--PVDP-NGEIVTYEVAYKLQKPDQVE---EKKCIPAADFNQTAGYLIKL 1274
            ||..|:|.:.:.|..  |.|| .|.:..|::::..:...|.|   |.......|::.....::  
  Rat   320 HAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTTANLTDWDPQKDLVL-- 382

  Fly  1275 NEGLYSFRVRANSIAGYGDFTEV------EHIKVEPPP----SYAKVFFWLLGIGLAFLIVSLFG 1329
                   ||.|::..|.|.:::.      :|...:.||    |:..|   :||:..|.:..:...
  Rat   383 -------RVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTSWVPV---VLGVLTALITAAALA 437

  Fly  1330 YVCYLHKRKVP------SNDLHMNTEVNPFYASMQY----------------IPDDWEVLRENII 1372
            .:....:||..      .:.:........|.|:..:                |.|:.:...|:: 
  Rat   438 LILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDV- 501

  Fly  1373 QLAP---------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNEN---ATDRERTNFLSEASV 1425
             |.|         ||:|.||.|.|..||.  .:|...:.|:|.:..:   ::|.|  .||.||:.
  Rat   502 -LIPEQQFTLGRMLGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASSDIE--EFLREAAC 561

  Fly  1426 MKEFDTYHVVRLLGVCSRGQP------ALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGV 1484
            |||||..||.:|:||..|.:.      .:|::..||.|||.::|.|              :|||.
  Rat   562 MKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA--------------SRIGE 612

  Fly  1485 TG-NVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD 1548
            .. |:...|   :.:..::||.||.||:::.|:||||||||||:|:|:||.:.|||::|.||..|
  Rat   613 NPFNLPLQT---LVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGD 674

  Fly  1549 YYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGG 1613
            |||:|....|||:|:..|||.|.:|:..|||::|||.:||:.|....||.|:.|.::..|:|.|.
  Rat   675 YYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLISGN 739

  Fly  1614 VMERPENCPDFLHKLMQRCWHHRSSARPSFL-------DIIAYL--------------------- 1650
            .:::|..|.:.::.||.:||......||||.       :|:.:|                     
  Rat   740 RLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIERAGQPA 804

  Fly  1651 ---EPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRM- 1711
               .|:.|..:...     ||||         :.:.:.|...:|.|               .|. 
  Rat   805 ENGSPELPCGEQSS-----SEAG---------DGSGMGAIGGIPSD---------------CRYI 840

  Fly  1712 ----GDYQQNSSLDQPPESPI 1728
                |..:....|:|.||||:
  Rat   841 FSPGGLAESPGQLEQQPESPL 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 16/89 (18%)
PTKc_InsR_like 1364..1652 CDD:173625 114/337 (34%)
Tyro3NP_058788.1 Ig 40..126 CDD:472250
Ig strand B 50..54 CDD:409553
Ig strand C 63..67 CDD:409553
Ig strand E 90..94 CDD:409553
Ig strand F 104..109 CDD:409553
Ig strand G 118..121 CDD:409553
IgI_2_Axl_Tyro3_like 130..209 CDD:409407
Ig strand A 130..133 CDD:409407
Ig strand A' 136..140 CDD:409407
Ig strand B 144..153 CDD:409407
Ig strand C 158..165 CDD:409407
Ig strand C' 167..170 CDD:409407
Ig strand E 174..185 CDD:409407
Ig strand F 188..197 CDD:409407
Ig strand G 201..209 CDD:409407
FN3 215..307 CDD:238020
fn3 315..396 CDD:394996 19/84 (23%)
PTKc_Tyro3 498..781 CDD:270659 113/305 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 804..827 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 842..864 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

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