DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and Insr

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_058767.2	Gene:	Insr / 24954	RGDID:	2917	Length:	1384	Species:	Rattus norvegicus

Alignment Length:	1483	Identity:	547/1483 - (36%)
Similarity:	776/1483 - (52%)	Gaps:	225/1483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---LNRSFPKLTEVTDYIIIYRVTGLHSL 400
            |..|||||.::..::||||:||||.|.|.|:....|   .:.|||||..:|||::::||.||.||
  Rat    35 CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESL 99

  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465
            ..:||||:||||::||..||||::....|.:|||:.|.:||||.||||||::|||..||||..||
  Rat   100 KDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRIL 164

  Fly   466 AENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTK 530
            ...|...:||.::..| ||. ..|||..:.:.....|.|.|:.         ...||....||..
  Rat   165 DSVEDNYIVLNKDDNE-ECG-DVCPGTAKGKTNCPATVINGQF---------VERCWTHSHCQKV 218

  Fly   531 CPEKCRNN-CIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQF-DSRCVT 593
            ||..|::: |..|..||.::|||.| .:.:....|::|||...:..|:::||..||.| |.|||.
  Rat   219 CPTICKSHGCTAEGLCCHKECLGNC-SEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVN 282

  Fly   594 ANECITLTKFETNSVYSG----IPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKEC----SSG 650
            .:.|..|.....||...|    :.:|.:||..||:||..:.:..||.||. |.|.|.|    ...
  Rat   283 FSFCQDLHYKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCL-GPCPKVCQILEGEK 346

  Fly   651 LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLK 715
            .|||:..|:|..|||:|.|:  |.|:|:  .|.::..||:..|..:.:|...|.:..:|.|.||.
  Rat   347 TIDSVTSAQELRGCTVINGS--LIINIR--GGNNLAAELEANLGLIEEISGFLKIRRSYALVSLS 407

  Fly   716 FFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLP 779
            ||:.|..|.|: .::...|:.|.|||::|.:||..|: .:.|.:|.:|||:|||||:|.|:::..
  Rat   408 FFRKLHLIRGE-TLEIGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFFHYNPKLCLSEIHKMEE 471

  Fly   780 MLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVF 844
            :..:|.: .|::|:...:||::.||...:|..:......:..:|.       .||..|.:    |
  Rat   472 VSGTKGR-QERNDIALKTNGDQASCENELLKFSFIRTSFDKILLR-------WEPYWPPD----F 524

  Fly   845 KDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKV---SSPEKSG----------VMVLSNLI 894
            :|   .:||:.::...||.|.|: ...|.| .:.|.|   ..|::|.          ..::..|.
  Rat   525 RD---LLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLK 586

  Fly   895 PYTNYSYYVRTMAISSE---LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPY 956
            |:|.|:.:|:|:...|:   ...|:||:...:|:...||...:.::.:.|.|:|.:.|.....|.
  Rat   587 PWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPN 651

  Fly   957 GVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSS 1021
            |.:|.|.:..:.....:.....|||.:.|          ..|::..|.|...|     .|:|.:.
  Rat   652 GNITHYLVYWERQAEDSELFELDYCLKGL----------KLPSRTWSPPFESD-----DSQKHNQ 701

  Fly  1022 QEYD------------DRKVQAGME-------FENALQNFIFVPNIRKSKNGSSDKSDGAEGAAL 1067
            .|||            |.::...:|       ||:.|.|.:|||....|.||:.|
  Rat   702 SEYDDSASECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAED---------- 756

  Fly  1068 DSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSS 1132
                      |.|||:||.               |..|.::|..|.         |..|..::||
  Rat   757 ----------TRPSRKRRS---------------LEEVGNVTATTP---------TLPDFPNISS 787

  Fly  1133 -----NKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYD 1192
                 :.:.:..|.|.:  |:...|...|||||.|.|.:.||.::.|.|:          ||...
  Rat   788 TIAPTSHEEHRPFEKVV--NKESLVISGLRHFTGYRIELQACNQDSPEER----------CSVAA 840

  Fly  1193 TVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK 1257
            .|...|..:..||   |:...:.|.....:.|.:.|..|.:|||.||.|||:|:....:::.  .
  Rat   841 YVSARTMPEAKAD---DIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELH--L 900

  Fly  1258 CIPAADFNQTAGYLIK-LNEGLYSFRVRANSIAGYGDFTEVEHIKV----EPPPSYAKVFFWLLG 1317
            |:....|....|..:: |:.|.||.||||.|:||.|.:||..:..|    :.|.:.||:.
  Rat   901 CVSRKHFALERGCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKII----- 960

  Fly  1318 IGLAFLIVSLFGYV-----CYLHKRKV--PSNDLHMNTEVNPFYASMQ-------YIPDDWEVLR 1368
            || ..:.|.||..|     .:|.||:.  |...|:.::  ||.|.|..       |:||:|||.|
  Rat   961 IG-PLIFVFLFSVVIGSIYLFLRKRQPDGPMGPLYASS--NPEYLSASDVFPSSVYVPDEWEVPR 1022

  Fly  1369 ENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYH 1433
            |.|..|..||||||||||||..|......|:...|:|||||:|:.|||..||:||||||.|..:|
  Rat  1023 EKITLLRELGQGSFGMVYEGNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHH 1087

  Fly  1434 VVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQ 1498
            |||||||.|:|||.|||||||..|||||:||:.||:..:..            ...|||...:.|
  Rat  1088 VVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENNP------------GRPPPTLQEMIQ 1140

  Fly  1499 MAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWM 1563
            |..|||||||||.|||||||||||||||||.|.||||||||||||||||||||||.|||||||||
  Rat  1141 MTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWM 1205

  Fly  1564 PPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKL 1628
            .||||:|||::::||::||||||||:.:||.||||||||||||::|:|||.::.|:|||:.|..|
  Rat  1206 SPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDL 1270

  Fly  1629 MQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKE-RNQLDAFAAVPL 1692
            |:.||......||:||:|:..|:... :..|.||||::||   :::..|.:| ..:.:....|||
  Rat  1271 MRMCWQFNPKMRPTFLEIVNLLKDDL-HPSFPEVSFFYSE---ENKAPESEELEMEFEDMENVPL 1331

  Fly  1693 DQDLQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSG 1745
            |:  ....|:|:|      |..:..|||.      |....|:  |:|::..:|
  Rat  1332 DR--SSHCQREEA------GCREGGSSLS------IKRTYDE--HIPYTHMNG 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	60/111 (54%)
		Furin-like	512..645	CDD:279142	47/138 (34%)
		FU	545..592	CDD:238021	18/47 (38%)
		Recep_L_domain	663..781	CDD:279382	44/118 (37%)
		FN3	1224..1302	CDD:238020	29/78 (37%)
		PTKc_InsR_like	1364..1652	CDD:173625	181/287 (63%)
		Pkinase_Tyr	1371..1650	CDD:285015	175/278 (63%)
Insr	NP_058767.2	Recep_L_domain	52..164	CDD:279382	60/111 (54%)
		Furin-like	179..337	CDD:279142	56/170 (33%)
		FU	234..281	CDD:238021	18/47 (38%)
		Recep_L_domain	359..472	CDD:279382	44/117 (38%)
		FN3	624..>667	CDD:238020	10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..710		8/26 (31%)
		Insulin-binding. /evidence=ECO:0000250	735..743		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..784		16/79 (20%)
		FN3	869..946	CDD:238020	29/78 (37%)
		Important for interaction with IRS1, SHC1 and STAT5B	998..1001		2/2 (100%)
		PTKc_InsR	1018..1305	CDD:133192	184/299 (62%)
		Pkinase_Tyr	1025..1292	CDD:285015	175/278 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1384		2/7 (29%)
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I908
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	816	1.000	Inparanoid score	I450
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm46041
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980