DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and igf1rb

DIOPT Version :9

Sequence 1:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_694501.1 Gene:igf1rb / 245702 ZFINID:ZDB-GENE-020503-2 Length:1380 Species:Danio rerio


Alignment Length:1473 Identity:549/1473 - (37%)
Similarity:763/1473 - (51%) Gaps:230/1473 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 MDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLNR------SFPKLTEVTDYIIIYRVTGLHSL 400
            :||.|.:.:|.:|||||||||:|.|.||.|.:..|:      ||||||.:|||::::||:||.||
Zfish    33 IDIGNDIGNFKRLENCTVIEGYLQILLIGDKNSNNQEVFRTLSFPKLTMITDYLLLFRVSGLESL 97

  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465
            |.:||||:||||..||...|||::....|.|:||:.||:||||.:|||||.:|||..::||..||
Zfish    98 STLFPNLAVIRGRNLFYNCALVIFELTSLKDIGLYNLRNITRGAIRIEKNPELCYLDSVDWSLIL 162

  Fly   466 AENETQLVVLTENGKE-KECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQT 529
               :.:|....:..|: |||. :.|||.:             |.|:.|      ..||.|..||.
Zfish   163 ---DAELNNFIDGNKQSKECG-NVCPGIM-------------EDNSQC------TRCWTSNHCQK 204

  Fly   530 KCPEKC-RNNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDS-RCV 592
            .|  :| :..|.|...||...|||.|.: .:.:.:|.:|:|.:....|::.||.|.|:|:. ||:
Zfish   205 VC--RCGQRACTDSGQCCHPQCLGSCSV-PDSDRACAACQNYNHEGRCVEDCPPGTYKFEGWRCI 266

  Fly   593 TANEC--ITLTKFETNSVYSGIPYNGQCITHCPTGYQKSEN-----KRMCEPCPGGKCDKECSSG 650
            |.:.|  :.|..::...:::     |:||:.||.|:.:.|:     ..:|..| .|.|||.|...
Zfish   267 TRDFCSKVHLPDYDRFVIHA-----GECISDCPPGFTRDESHGVSVSMLCTAC-DGPCDKICDEK 325

  Fly   651 LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLK 715
            :|||::.|:...|||:|.|.  |.|:|:|  |.::..||:..|..:..:...:.:..::.|.||.
Zfish   326 VIDSVDAAQSLKGCTVIKGN--LHINIRR--GTNIASELENFLGLIKTVTGYIKIRSSHTLTSLS 386

  Fly   716 FFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLP 779
            |.:||..|.|:...| :.||...|||:.|..||..:| .:.|.:|.::|..|||||:|.|.::..
Zfish   387 FLKSLRYIHGEELWD-NTYAFAALDNQHLQLLWDWSQHNLTISEGKLYFRLNPKLCMSEIRKMWA 450

  Fly   780 MLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVF 844
            ....|..|.|:.   ..:||:|.||||.:|..|..:..:|...|       :.|..:||      
Zfish   451 KTGIKDNFVERD---FRNNGDRASCGTKILKFTSNNTRSNQIKL-------MWESYRPS------ 499

  Fly   845 KDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRW---KVSSPEKS----GVMVLSNLIPYTNYS 900
             |.|..:.|:.|:...|:.|.|: ...|.| .|.|   .|..|::.    || |||.|.|:|.|:
Zfish   500 -DSRDLVNFIVYYKEAPFQNITEFDGQDSCGSDSWDMVNVDLPDEKILNPGV-VLSTLKPWTQYA 562

  Fly   901 YYVRTMAISSE---------LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPY 956
            .:|:.:.:..|         ....:|:|...||.|..||...::.|.|.|.||:.|.|:....|.
Zfish   563 IFVKAVTLIVEDRDRDKDRLHLGPQSEVVYIRTKPSAPSMPVDIRAYANSSSKLVVRWAPPLAPN 627

  Fly   957 GVLTRYFIKAKLINRPTRNNNRDYCTEPL---VKAMENDLPATTPTKKISDPLAGD-----CKCV 1013
            |..|.|.::.|...........:||::.|   |:.....|..|..||.......|.     |.| 
Zfish   628 GNNTYYVLRWKQQGEDRELYQHNYCSKELKIPVRVSATGLTDTEDTKPTYHETGGRDKTPCCPC- 691

  Fly  1014 EGSKKTSSQEYDDRKVQAGM----EFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPN 1074
               .||   |.|.::::..:    .|||.|.|.||.|.                           
Zfish   692 ---PKT---EEDLKRIEDDIYYRKAFENFLHNAIFTPR--------------------------- 723

  Fly  1075 GGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV 1139
                .|.|||||:.....:..:.  .||....::|           |..:.|:|.......|.|.
Zfish   724 ----PPDRRRRDLFGVANVTSIH--TLLAGHWNLT-----------EGNFSDDEPPRREFSFLER 771

  Fly  1140 FAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFA 1204
            ..||     .|.....|:.||.|.|.:.||.||:..            ||....||..||..:.|
Zfish   772 KVKE-----RHIEITGLQPFTVYRIDLHACNEEVRH------------CSAAAFVFSRTKAAEKA 819

  Fly  1205 DIVMDLKVDLEHA---NNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQ 1266
            |       |:..:   ...|..|.::|..|..|||.|:.||:.|:|  ..:.|:.:|:....:.:
Zfish   820 D-------DIPGSVTWEGQEDSVFLKWPEPDKPNGLIMLYEIQYRL--GTEPEKHECVSRQHYRK 875

  Fly  1267 TAGY-LIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVE--PPPSYAKVFFWLLGIGLAFLIVS-- 1326
            ..|. |..|..|.||.||||.|:||.|.:||.....|.  ...||..|.|  :.|..|.|:::  
Zfish   876 HKGVKLSNLGPGNYSVRVRATSLAGNGSWTEPIAFSVHQLEQSSYDPVMF--IAILPALLLIAGL 938

  Fly  1327 -LFGYVCYLHKRKVPSNDLHMN----TEVNP--FYASMQYIPDDWEVLRENIIQLAPLGQGSFGM 1384
             :|||. :::|.:  :||...|    ..|||  |.|:..|:||:|||.||.|.....||||||||
Zfish   939 VVFGYT-WMNKNR--NNDRLGNGVLYASVNPEYFSAAEMYVPDEWEVEREKITMCRELGQGSFGM 1000

  Fly  1385 VYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALV 1449
            |||||.|....:..:...|||||||:|:..||..||:||||||||:.:||||||||.|:|||.||
Zfish  1001 VYEGIAKGVVKDEPETRVAIKTVNESASLHERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLV 1065

  Fly  1450 VMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKK 1514
            :||||.:||||||||:.|..|.             |.::..|...::.|||.|||||||||.|.|
Zfish  1066 IMELMTRGDLKSYLRSLRSVEN-------------TSSLPLPPLKKMIQMAGEIADGMAYLNANK 1117

  Fly  1515 FVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDV 1579
            ||||||||||||||:|.||||||||||||||||||||||.|||||||||.||||:|||:::.|||
Zfish  1118 FVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTNSDV 1182

  Fly  1580 FSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFL 1644
            :||||||||:||||.|||||:|||||||:|::||::::|:||||.|.:||:.||.:....|||||
Zfish  1183 WSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL 1247

  Fly  1645 DIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLD-----AFAAVPLDQDLQDREQQED 1704
            :||:.::... .:.|||.||::||      |.:..:..:||     ....|||:.....:.....
Zfish  1248 EIISSIKEDL-EAGFKETSFFYSE------ENKPPDTEELDMENVGTMENVPLEPSSSLQPLAPS 1305

  Fly  1705 ATTPLRMGDYQQN-SSLDQPPESPIAMVDDQGSH-LPFSLPSG 1745
            .:.|.:.....|: |:...||.||    .....| ||.|..:|
Zfish  1306 ISPPQQCTAAAQSCSTPSSPPSSP----SSTDKHPLPTSAANG 1344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382 62/114 (54%)
Furin-like 512..645 CDD:279142 41/141 (29%)
FU 545..592 CDD:238021 16/47 (34%)
Recep_L_domain 663..781 CDD:279382 41/118 (35%)
FN3 1224..1302 CDD:238020 29/78 (37%)
PTKc_InsR_like 1364..1652 CDD:173625 184/287 (64%)
Pkinase_Tyr 1371..1650 CDD:285015 179/278 (64%)
igf1rbNP_694501.1 Recep_L_domain 47..162 CDD:279382 62/114 (54%)
Furin-like 176..320 CDD:279142 49/172 (28%)
FU 219..265 CDD:238021 15/46 (33%)
Recep_L_domain 338..449 CDD:279382 41/115 (36%)
FN3 483..595 CDD:238020 31/126 (25%)
FN3 600..>644 CDD:238020 14/43 (33%)
FN3 823..910 CDD:238020 30/88 (34%)
PTKc_InsR_like 980..1255 CDD:173625 184/287 (64%)
Pkinase_Tyr 987..1253 CDD:285015 179/278 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 358 1.000 Domainoid score I923
eggNOG 1 0.900 - - E2759_KOG4258
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H30997
Inparanoid 1 1.050 795 1.000 Inparanoid score I489
OMA 1 1.010 - - QHG49983
OrthoDB 1 1.010 - - D120934at33208
OrthoFinder 1 1.000 - - FOG0001171
OrthoInspector 1 1.000 - - otm24447
orthoMCL 1 0.900 - - OOG6_103219
Panther 1 1.100 - - O PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4609
SonicParanoid 1 1.000 - - X893
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1514.870

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