DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and igf1ra

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_694500.1	Gene:	igf1ra / 245701	ZFINID:	ZDB-GENE-020503-1	Length:	1405	Species:	Danio rerio

Alignment Length:	1526	Identity:	574/1526 - (37%)
Similarity:	790/1526 - (51%)	Gaps:	225/1526 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 SGT-QSRWTRSESNPTMRLSQNVKPC-------KSMDIRNMVSHFNQLENCTVIEGFLLIDLIND 371
            ||| :..||.. ..|.:.||.....|       ..:||||.::.|.:||||||:||:|.|.||.|
Zfish     3 SGTARDVWTLF-WGPALFLSTICLRCARGEVCGPHIDIRNDITEFKKLENCTVVEGYLQILLIGD 66

  Fly   372 A-SPLNR------SFPKLTEVTDYIIIYRVTGLHSLSKIFPNLSVIRGNKLFDGYALVVYSNFDL 429
            . :.||:      ||||||.|||||:::||:||.|||.:||||:||||..||..||||::....|
Zfish    67 KNNNLNQEHFRTLSFPKLTMVTDYILLFRVSGLDSLSVLFPNLNVIRGRNLFYNYALVIFEMTSL 131

  Fly   430 MDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEIR 494
            .|:||:.||:||||.:|||||.:|||..::|| .:|.:.|....: ..|.:.|||. ..||| |.
Zfish   132 KDIGLYNLRNITRGAIRIEKNPELCYLDSVDW-SLLMDAEFNNYI-AGNKQTKECG-DVCPG-IN 192

  Fly   495 IEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTKCPEKC-RNNCIDEHTCCSQDCLGGCVIDK 558
            .:..|   .|....|     .|....||.|..||..||::| :..|.|...||...|||.|. :.
Zfish   193 KDRPH---CIRTSFN-----DNYSYRCWTSNHCQKVCPKECEKRACTDAGQCCHPQCLGSCT-EA 248

  Fly   559 NGNESCISCRNVSFNNICMDSCPKGYYQFDS-RCVTANECITLTKFETNSVYSGIPYNGQCITHC 622
            :.:::|.:|::....:.|:::||...|:|:. ||:|...|   .:....|....:.:||:|:..|
Zfish   249 DNDKACAACQHYFHEDRCVEACPPDTYKFEGWRCITMEMC---ARVHLPSEVDFVIHNGECMPDC 310

  Fly   623 PTGYQKSENKRM-CEPCPGGKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVM 686
            |.|:.::|...| |..| .|.|||.|.|..|||::.|:...|||:|.|.  |.|:|:|  |.::.
Zfish   311 PPGFTRNETLSMFCSAC-DGLCDKVCESKTIDSVDAAQSLQGCTVIKGN--LQINIRR--GNNIA 370

  Fly   687 DELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPN 751
            .||:..:..:..:...:.:..|:.|.||.|.:||..|.|:..:| :.||.:.:||.:|..||...
Zfish   371 SELESFMGLIQTVTGYVRIKHTHTLGSLSFLKSLRYIVGEELVD-NTYAFHAVDNHNLQYLWDWT 434

  Fly   752 Q-TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQS 815
            | .:.||.|.::|.||||||:|.|.::....:.:.|..| .||  .|||.|.||.:.:|.  .:|
Zfish   435 QHNLTIRTGKLYFRFNPKLCMSEIRKMWEKTSVREKMAE-DDV--RSNGERASCESYILK--FRS 494

  Fly   816 VGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWK 878
            ....|..:.:|     .|..:|       .|.|..|.|:.|:...|:.|.|: ...|.| .:.|.
Zfish   495 NHTQSTRIKLT-----WERYRP-------PDYRDLISFIVYYKEAPFQNITEFDGQDGCGSNSWN 547

  Fly   879 ---VSSPEKSGV---MVLSNLIPYTNYSYYVRTMAISSE---LTNAESDVKNFRTNPGRPSKVTE 934
               |..|::..:   ::||.|.|:|.|:.:|:.:.:..|   :..|:|:|...|||...||...:
Zfish   548 MVDVDLPQEKSIDPGVLLSPLKPWTQYAIFVKAVTLVVEDKHVGGAKSEVVYIRTNASAPSMPLD 612

  Fly   935 VVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPL----------VKAM 989
            ..|.|.|.|.:.|.||....|.|..|.|.::.:...........:||::.|          :..|
Zfish   613 ARAYANSSSSLMVKWSPPIAPNGNKTFYVLRWQQQAEDGELYQHNYCSKELKIPIRISATSLSDM 677

  Fly   990 ENDLPATTPTKKISDPLAGD---CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKS 1051
            |.:   |.|||  ||...|:   |.|.: :|:....|.:||..:  ..|||.|.|.||.|.
Zfish   678 EGE---TKPTK--SDVAGGEKGCCPCPK-TKEDLKAEAEDRSYR--KVFENFLHNSIFTPR---- 730

  Fly  1052 KNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHV-RSITDDTDAF 1115
                                       .|.|:|||      |..|..|.|:..| |:|:
Zfish   731 ---------------------------PPDRKRRD------LMGVANSTLVSGVSRNIS------ 756

  Fly  1116 FEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQ----THFV-FEKLRHFTRYAIFVVACREEIPS 1175
                         .|.||....|:..||.|.::    |.|: ...||.||.|.|.:.||..|:
Zfish   757 -------------VLESNITQPELPEKEYPFSEGKVHTEFMEIHNLRPFTVYRIDIHACNYEV-- 806

  Fly  1176 EKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVT 1240
                      ..||....||..||....||.:.. .|..|.....|..|.:||..|:.|||.|:.
Zfish   807 ----------HRCSAAAFVFSRTKPADKADDIPG-SVTQERDEKGEGIVLLRWPEPLHPNGLILM 860

  Fly  1241 YEVAYKLQKPDQVEEKKCIPAADFNQTAG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEP 1304
            ||:.|:|  ..:.|:.:|:....:....| .|..|..|.||.||||.|:||.|.:||.....|.|
Zfish   861 YEIKYRL--GTEAEKHECVSRQQYKVLRGAQLSNLASGNYSARVRATSLAGNGSWTEPVSFYVPP 923

  Fly  1305 PP-SYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMN----TEVNPFYAS--MQYIPD 1362
            |. :|....:..:.|.:..|::.||..|..:...|..::|...|    ..|||.|.|  ..|:||
Zfish   924 PKRNYDNALYVAIIIPVIVLLLLLFVIVAVIIVTKKRNSDRIGNGVLYASVNPEYFSPFEMYVPD 988

  Fly  1363 DWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMK 1427
            :|||.||.|.....|||||||||||||.|....:..:...|||||||:|:.|||..||:||||||
Zfish   989 EWEVAREKITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASVRERIEFLNEASVMK 1053

  Fly  1428 EFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPT 1492
            ||:.:||||||||.|:|||.||:||||.:|||||:||:.|.:|:           |.:....||
Zfish  1054 EFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRSKEQ-----------GSSSQSLPP- 1106

  Fly  1493 YGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGL 1557
            ..::.|||.|||||||||.|.|||||||||||||||:|.||||||||||||||||||||||.|||
Zfish  1107 LKKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL 1171

  Fly  1558 LPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCP 1622
            ||||||.||||:|||:::.|||:||||||||:||||.|||||:|||||||:|::||::::|:|||
Zfish  1172 LPVRWMSPESLKDGVFTTNSDVWSFGVVLWEIATLAEQPYQGMSNEQVLRFVMEGGLLDKPDNCP 1236

  Fly  1623 DFLHKLMQRCWHHRSSARPSFLDII----AYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERN- 1682
            |.|.:||:.||.:....|||||:||    ..|||     .|:||||::||   :::..:.:|.:
Zfish  1237 DMLFELMRMCWQYNPKMRPSFLEIINSIKEELEP-----PFREVSFFYSE---ENKPPDTEELDM 1293

  Fly  1683 QLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQP------PESPIAMVDDQGSHLPFS 1741
            :::....||||        ......|...|:....|...||      |.:|:.......:..|.|
Zfish  1294 EVENMENVPLD--------PRSTLAPSSQGNTGIQSQNPQPLSPAQGPGTPLGSAQTPSTSPPSS 1350

  Fly  1742 LPSGFIASSTPDGQTVMATAFQNIPAAQGDI 1772
            ..|..:|.....||.          ||.|.:
Zfish  1351 SASPGLALDKHSGQV----------AANGPV 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	65/115 (57%)
		Furin-like	512..645	CDD:279142	41/135 (30%)
		FU	545..592	CDD:238021	14/47 (30%)
		Recep_L_domain	663..781	CDD:279382	42/118 (36%)
		FN3	1224..1302	CDD:238020	30/78 (38%)
		PTKc_InsR_like	1364..1652	CDD:173625	186/291 (64%)
		Pkinase_Tyr	1371..1650	CDD:285015	180/282 (64%)
igf1ra	NP_694500.1	Recep_L_domain	51..167	CDD:279382	65/116 (56%)
		Furin-like	182..333	CDD:279142	51/165 (31%)
		FU	235..275	CDD:214589	11/40 (28%)
		Recep_L_domain	351..465	CDD:279382	42/118 (36%)
		FN3	497..602	CDD:238020	28/116 (24%)
		FN3	607..>651	CDD:238020	13/43 (30%)
		FN3	844..921	CDD:238020	30/78 (38%)
		PTKc_IGF-1R	990..1266	CDD:133193	185/287 (64%)
		Pkinase_Tyr	997..1264	CDD:285015	180/278 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I923
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H30997
Inparanoid	1	1.050	795	1.000	Inparanoid score	I489
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm24447
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840