DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and insrb

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_001116701.1	Gene:	insrb / 245700	ZFINID:	ZDB-GENE-020503-4	Length:	1348	Species:	Danio rerio

Alignment Length:	1462	Identity:	536/1462 - (36%)
Similarity:	756/1462 - (51%)	Gaps:	212/1462 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLI-----NDASPLNRSFPKLTEVTDYIIIYRVTGLH 398
            |.|.||||:.::...|||||||||.|.|.|:     .|...|  |||||..||||::|:||.||.
Zfish    28 CPSTDIRNIATNLRVLENCTVIEGHLKILLMFKTTQEDFRGL--SFPKLVMVTDYLLIFRVYGLE 90

  Fly   399 SLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLE 463
            ||..:||||:||||:.||..||||::....:.::|||.|.:||||.||||||..|||..|:||.:
Zfish    91 SLGSLFPNLTVIRGSNLFFNYALVMFEMIQMKEIGLHSLTNITRGAVRIEKNPNLCYLSTLDWSK 155

  Fly   464 ILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQ 528
            ||...|...:|  .|..:.||. :.|||.|........|.|.|         |....|||...||
Zfish   156 ILDSVEDNYIV--ANKDDLECG-NICPGTIAGTISCKQTTING---------NFGERCWNQNHCQ 208

  Fly   529 TKCPEKC-RNNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDS-RC 591
            ..||.:| ...|.....||.:.|||||.:..|..: |::|||..:...|:|.||.|||.|.| ||
Zfish   209 RICPSECVHGACTSHKECCHEQCLGGCSVPGNSTK-CVACRNFLYGEACVDRCPPGYYTFKSWRC 272

  Fly   592 VTANECITL---TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRM-CEPCPGGKCDKECSS-GL 651
            |:...|..|   .|.::...::.:.:||.||..||:||....:..: |.||. |:|.|.|:. ..
Zfish   273 VSLQFCQDLHNQCKDKSGDCHAYVIHNGACIPECPSGYTTVNSTSLTCMPCT-GRCPKVCTGVQT 336

  Fly   652 IDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKF 716
            :||:..|:...|||::.|    ::.||...|..:..||:..|..:.:|...|.:...|.|.||.|
Zfish   337 VDSVTAAQALRGCTVLNG----SLIIKISGGNSIAAELESSLGQLEEITGYLTIRRAYALVSLSF 397

  Fly   717 FQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLPM 780
            .:.|..|.|: .:|...|:.:.:||::|.:||..|: .:.|.||.:.|..|.|||.|.|.::...
Zfish   398 LRKLHLIRGE-TLDGGNYSFHAMDNQNLRQLWDWNKHNLTILKGRMKFIQNGKLCKSEILRMEQA 461

  Fly   781 LASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEI-GEPQKPSNATIVF 844
            ..:|.:.   :|:..:.  ::..|.:.:|..|        .:..::.|:.| .|...||:    |
Zfish   462 TGTKNRM---NDISNEK--DQSYCESHILKFT--------QIRTMSDKILIRWESFWPSD----F 509

  Fly   845 KDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKVSSPE-----------KSGVMVLSNLIPY 896
            :|   .:||:..:...|:.|.|: ...|.| .:.|.::..|           :.|.:::. |.|:
Zfish   510 RD---LLGFMVLYKEAPHRNVTEYDGQDACGSNSWAIADVEPPQRPSEGKEVEPGYLIMP-LKPW 570

  Fly   897 TNYSYYVRTMAISSE---LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGV 958
            |.|:..|:....:||   :..|::::...|||..|||...:..:.:.|.|:|.:.|.....|.|.
Zfish   571 TQYAVMVKAQLAASEDHQVRGAKTEIIYVRTNATRPSVPLDPHSWSNSSSQIILKWKPPSDPNGN 635

  Fly   959 LTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPT------------KKISDPLAGDCK 1011
            :|.|.|..:..:....:...|||.:.:      .:|:.|||            .::.|.....|.
Zfish   636 ITHYIIYCQKQSEDITHYKFDYCQQGM------KVPSHTPTHHDVEEDQKLNQTEVPDQKGHCCA 694

  Fly  1012 C--VEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPN 1074
            |  .|...|..::|.:.||.     |||.|.|.:|.|...:.:     :|.|...|.|     ||
Zfish   695 CPKTEMQLKKEAEETEFRKT-----FENYLHNEVFEPRPHRRR-----RSVGVANATL-----PN 744

  Fly  1075 GGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV 1139
            .| |.|:       :.|...                            |....|:..|.|..::.
Zfish   745 FG-TTPT-------IIPNFP----------------------------TTSIPEEEKSRKMVFKA 773

  Fly  1140 FAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFA 1204
            .:||.      .|...|.|||.|.|.:.||.:  |::..|        ||....|...|..:..|
Zfish   774 SSKEA------MVISNLLHFTSYQIEIHACND--PTDPGR--------CSMPTYVKARTLPELKA 822

  Fly  1205 DIVMDLKVDLEHANNTESP--VRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQT 1267
            |::.:   .:.|....:.|  |.:||..|..|||.|:.|||.| |:..|..|::.|:....:.:.
Zfish   823 DVIAE---PVTHEFFPDEPDVVYIRWKEPKTPNGMIILYEVKY-LRMSDNYEDQICVSRISYEKN 883

  Fly  1268 AGYLIKL-NEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYV 1331
            .||.::: :.|.||.||||.|:||.|.:|:..:..|:......|:.. :|.|.: ||:|.|....
Zfish   884 HGYRLRVGHPGNYSVRVRATSLAGNGSWTDPAYFYVQDREMSMKIVI-ILAICI-FLLVILASVG 946

  Fly  1332 CYLHKRKV---PSNDLHMNTEVNPFYASMQ--YIPDDWEVLRENIIQLAPLGQGSFGMVYEGILK 1391
            .::.|:|.   |:..|..::  ||.|.|..  ||||:|||.||.|..:..|||||||||||||.|
Zfish   947 YFVLKKKQTEGPTGPLIASS--NPEYISANDVYIPDEWEVPREKITVMRELGQGSFGMVYEGIAK 1009

  Fly  1392 SFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKK 1456
            .......|...|:|||||:|:.|||..||:||||||.|..:||||||||.|:|||.|||||||..
Zfish  1010 DIIKGEPDTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLVVMELMTH 1074

  Fly  1457 GDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLA 1521
            ||||||||:.||:..:..            ...|||...:.||:.|||||||||.||||||||||
Zfish  1075 GDLKSYLRSLRPDAENNP------------GSPPPTLKEMIQMSAEIADGMAYLNAKKFVHRDLA 1127

  Fly  1522 ARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVL 1586
            |||||||:|.||||||||||||||||||||||.|||||||||.||||:|||:::.||.:||||||
Zfish  1128 ARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVL 1192

  Fly  1587 WEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE 1651
            ||::|||.||||||||||||::|:|||.::||||||:.:|.|||.||.:....||:|.:||..::
Zfish  1193 WEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPENCPERMHNLMQMCWQYNPKMRPTFHEIIEMIK 1257

  Fly  1652 PQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQ 1716
            ... :..|:||||::||   :::..|.:|           .|.|.::.|     :.||....|.|
Zfish  1258 EDL-HPTFQEVSFFYSE---ENKAPESEE-----------FDMDFENME-----SIPLDPSSYSQ 1302

  Fly  1717 ---NSSLDQPPESPIAMVDDQGSHLPFSLPSG 1745
               :.|.|..|.  :.:..:...|:|::..:|
Zfish  1303 REESHSRDNGPS--VGLRGNYEEHVPYTHMNG 1332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	62/113 (55%)
		Furin-like	512..645	CDD:279142	50/138 (36%)
		FU	545..592	CDD:238021	22/47 (47%)
		Recep_L_domain	663..781	CDD:279382	38/118 (32%)
		FN3	1224..1302	CDD:238020	30/78 (38%)
		PTKc_InsR_like	1364..1652	CDD:173625	185/287 (64%)
		Pkinase_Tyr	1371..1650	CDD:285015	180/278 (65%)
insrb	NP_001116701.1	Recep_L_domain	45..157	CDD:279382	62/113 (55%)
		Furin-like	173..329	CDD:279142	59/167 (35%)
		FU	226..273	CDD:238021	22/47 (47%)
		Recep_L_domain	348..462	CDD:279382	38/118 (32%)
		FN3	606..>649	CDD:238020	11/42 (26%)
		FN3	838..919	CDD:238020	31/81 (38%)
		PTKc_InsR	982..1269	CDD:133192	188/299 (63%)
		Pkinase_Tyr	989..1256	CDD:285015	180/278 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I923
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	795	1.000	Inparanoid score	I489
OMA	1	1.010	-	-		QHG49983
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm24447
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840