Protein Alignment InR and insrb

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001116701.1
• Gene: insrb / 245700
• ZFINID: ZDB-GENE-020503-4
• Length: 1348
• Species: Danio rerio
• Alignment Length: 1462
• Identity: 536/1462 - (36%)
• Similarity: 756/1462 - (51%)
• Gaps: 212/1462 - (14%)

  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLI-----NDASPLNRSFPKLTEVTDYIIIYRVTGLH 398
            |.|.||||:.::...|||||||||.|.|.|:     .|...|  |||||..||||::|:||.||.
Zfish    28 CPSTDIRNIATNLRVLENCTVIEGHLKILLMFKTTQEDFRGL--SFPKLVMVTDYLLIFRVYGLE 90

  Fly   399 SLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLE 463
            ||..:||||:||||:.||..||||::....:.::|||.|.:||||.||||||..|||..|:||.:
Zfish    91 SLGSLFPNLTVIRGSNLFFNYALVMFEMIQMKEIGLHSLTNITRGAVRIEKNPNLCYLSTLDWSK 155

  Fly   464 ILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQ 528
            ||...|...:|  .|..:.||. :.|||.|........|.|.|         |....|||...||
Zfish   156 ILDSVEDNYIV--ANKDDLECG-NICPGTIAGTISCKQTTING---------NFGERCWNQNHCQ 208

  Fly   529 TKCPEKC-RNNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDS-RC 591
            ..||.:| ...|.....||.:.|||||.:..|..: |::|||..:...|:|.||.|||.|.| ||
Zfish   209 RICPSECVHGACTSHKECCHEQCLGGCSVPGNSTK-CVACRNFLYGEACVDRCPPGYYTFKSWRC 272

  Fly   592 VTANECITL---TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRM-CEPCPGGKCDKECSS-GL 651
            |:...|..|   .|.::...::.:.:||.||..||:||....:..: |.||. |:|.|.|:. ..
Zfish   273 VSLQFCQDLHNQCKDKSGDCHAYVIHNGACIPECPSGYTTVNSTSLTCMPCT-GRCPKVCTGVQT 336

  Fly   652 IDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKF 716
            :||:..|:...|||::.|    ::.||...|..:..||:..|..:.:|...|.:...|.|.||.|
Zfish   337 VDSVTAAQALRGCTVLNG----SLIIKISGGNSIAAELESSLGQLEEITGYLTIRRAYALVSLSF 397

  Fly   717 FQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQ-TVFIRKGGVFFHFNPKLCVSTINQLLPM 780
            .:.|..|.|: .:|...|:.:.:||::|.:||..|: .:.|.||.:.|..|.|||.|.|.::...
Zfish   398 LRKLHLIRGE-TLDGGNYSFHAMDNQNLRQLWDWNKHNLTILKGRMKFIQNGKLCKSEILRMEQA 461

  Fly   781 LASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEI-GEPQKPSNATIVF 844
            ..:|.:.   :|:..:.  ::..|.:.:|..|        .:..::.|:.| .|...||:    |
Zfish   462 TGTKNRM---NDISNEK--DQSYCESHILKFT--------QIRTMSDKILIRWESFWPSD----F 509

  Fly   845 KDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKVSSPE-----------KSGVMVLSNLIPY 896
            :|   .:||:..:...|:.|.|: ...|.| .:.|.::..|           :.|.:::. |.|:
Zfish   510 RD---LLGFMVLYKEAPHRNVTEYDGQDACGSNSWAIADVEPPQRPSEGKEVEPGYLIMP-LKPW 570

  Fly   897 TNYSYYVRTMAISSE---LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGV 958
            |.|:..|:....:||   :..|::::...|||..|||...:..:.:.|.|:|.:.|.....|.|.
Zfish   571 TQYAVMVKAQLAASEDHQVRGAKTEIIYVRTNATRPSVPLDPHSWSNSSSQIILKWKPPSDPNGN 635

  Fly   959 LTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPT------------KKISDPLAGDCK 1011
            :|.|.|..:..:....:...|||.:.:      .:|:.|||            .::.|.....|.
Zfish   636 ITHYIIYCQKQSEDITHYKFDYCQQGM------KVPSHTPTHHDVEEDQKLNQTEVPDQKGHCCA 694

  Fly  1012 C--VEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPN 1074
            |  .|...|..::|.:.||.     |||.|.|.:|.|...:.:     :|.|...|.|     ||
Zfish   695 CPKTEMQLKKEAEETEFRKT-----FENYLHNEVFEPRPHRRR-----RSVGVANATL-----PN 744

  Fly  1075 GGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV 1139
            .| |.|:       :.|...                            |....|:..|.|..::.
Zfish   745 FG-TTPT-------IIPNFP----------------------------TTSIPEEEKSRKMVFKA 773

  Fly  1140 FAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFA 1204
            .:||.      .|...|.|||.|.|.:.||.:  |::..|        ||....|...|..:..|
Zfish   774 SSKEA------MVISNLLHFTSYQIEIHACND--PTDPGR--------CSMPTYVKARTLPELKA 822

  Fly  1205 DIVMDLKVDLEHANNTESP--VRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQT 1267
            |::.:   .:.|....:.|  |.:||..|..|||.|:.|||.| |:..|..|::.|:....:.:.
Zfish   823 DVIAE---PVTHEFFPDEPDVVYIRWKEPKTPNGMIILYEVKY-LRMSDNYEDQICVSRISYEKN 883

  Fly  1268 AGYLIKL-NEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYV 1331
            .||.::: :.|.||.||||.|:||.|.:|:..:..|:......|:.. :|.|.: ||:|.|....
Zfish   884 HGYRLRVGHPGNYSVRVRATSLAGNGSWTDPAYFYVQDREMSMKIVI-ILAICI-FLLVILASVG 946

  Fly  1332 CYLHKRKV---PSNDLHMNTEVNPFYASMQ--YIPDDWEVLRENIIQLAPLGQGSFGMVYEGILK 1391
            .::.|:|.   |:..|..::  ||.|.|..  ||||:|||.||.|..:..|||||||||||||.|
Zfish   947 YFVLKKKQTEGPTGPLIASS--NPEYISANDVYIPDEWEVPREKITVMRELGQGSFGMVYEGIAK 1009

  Fly  1392 SFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKK 1456
            .......|...|:|||||:|:.|||..||:||||||.|..:||||||||.|:|||.|||||||..
Zfish  1010 DIIKGEPDTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLVVMELMTH 1074

  Fly  1457 GDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLA 1521
            ||||||||:.||:..:..            ...|||...:.||:.|||||||||.||||||||||
Zfish  1075 GDLKSYLRSLRPDAENNP------------GSPPPTLKEMIQMSAEIADGMAYLNAKKFVHRDLA 1127

  Fly  1522 ARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVL 1586
            |||||||:|.||||||||||||||||||||||.|||||||||.||||:|||:::.||.:||||||
Zfish  1128 ARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVL 1192

  Fly  1587 WEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE 1651
            ||::|||.||||||||||||::|:|||.::||||||:.:|.|||.||.:....||:|.:||..::
Zfish  1193 WEISTLAEQPYQGLSNEQVLKFVMDGGYLDRPENCPERMHNLMQMCWQYNPKMRPTFHEIIEMIK 1257

  Fly  1652 PQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQ 1716
            ... :..|:||||::||   :::..|.:|           .|.|.::.|     :.||....|.|
Zfish  1258 EDL-HPTFQEVSFFYSE---ENKAPESEE-----------FDMDFENME-----SIPLDPSSYSQ 1302

  Fly  1717 ---NSSLDQPPESPIAMVDDQGSHLPFSLPSG 1745
               :.|.|..|.  :.:..:...|:|::..:|
Zfish  1303 REESHSRDNGPS--VGLRGNYEEHVPYTHMNG 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	62/113 (55%)
		Furin-like	510..645	CDD:395614	50/140 (36%)
		Recep_L_domain	663..781	CDD:460032	38/118 (32%)
		FN3	791..>964	CDD:442628	43/189 (23%)
		FN3	1224..1302	CDD:238020	30/78 (38%)
		PTKc_InsR_like	1364..1652	CDD:173625	185/287 (64%)
insrb	NP_001116701.1	Recep_L_domain	45..157	CDD:460032	62/113 (55%)
		Furin-like	173..329	CDD:395614	59/167 (35%)
		Recep_L_domain	348..463	CDD:460032	38/119 (32%)
		FN3	<567..>642	CDD:442628	22/74 (30%)
		FN3	606..>649	CDD:238020	11/42 (26%)
		FN3	838..919	CDD:238020	31/81 (38%)
		Insulin_TMD	916..958	CDD:465543	10/43 (23%)
		PTKc_InsR	982..1269	CDD:133192	188/299 (63%)