DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and insra

DIOPT Version :9

Sequence 1:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:XP_005171317.1 Gene:insra / 245699 ZFINID:ZDB-GENE-020503-3 Length:1362 Species:Danio rerio


Alignment Length:1481 Identity:548/1481 - (37%)
Similarity:773/1481 - (52%) Gaps:222/1481 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---LNRSFPKLTEVTDYIIIYRVTGLHSL 400
            |.|.||||.|::...|||||||||.|.|.|:....|   ...|:||||.||||::::||.||.||
Zfish    36 CSSKDIRNNVTNLRVLENCTVIEGHLKILLMFTTKPEDFRGLSYPKLTVVTDYLLLFRVYGLESL 100

  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465
            |.:||||:|:|||.||..||||::....|.::|||.|.:||||.||:|||..|||..|:||..||
Zfish   101 SDLFPNLTVVRGNNLFFNYALVLFEMLQLKEIGLHSLMNITRGAVRVEKNPDLCYLSTLDWSMIL 165

  Fly   466 AENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTK 530
            ...|...:|..:|  ::||. ..|||.:..:.....|.|.|:.:         ..|||.|.||..
Zfish   166 DSVEDNYIVANKN--DRECG-DICPGTVLGKTTCPLTTINGDFS---------ERCWNQKYCQRM 218

  Fly   531 CPEKCRNN-CIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDS-RCVT 593
            ||..|::. |..:..||...||||| ::.:.:..|::|||...||:|::.||.|:|.|.. |||:
Zfish   219 CPSSCKHRACTKDSQCCHDQCLGGC-LEPHSSNKCVACRNFMHNNMCVEKCPHGFYTFKGWRCVS 282

  Fly   594 ANECITL---TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRM-CEPCPGGKCDKECSSGL--I 652
            .:.|..|   .|......:..:.:||.||..||:||....:..: |.|| .|.|.|.| .||  :
Zfish   283 FSFCQELHNKCKQGKGDCHEYVIHNGACIPECPSGYTTVNSTTLNCTPC-AGLCPKVC-MGLKTV 345

  Fly   653 DSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFF 717
            ||:..|:...|||:|.|:  |.|:|:  .|.::..||:..|..:.:|...|.|..:|.|.||.|.
Zfish   346 DSVTAAQALRGCTVINGS--LVINIR--GGNNIAAELEANLGQLEEITGYLTVRHSYALVSLSFL 406

  Fly   718 QSLTEISGDPPMDADKYALYVLDNRDLDELWG-PNQTVFIRKGGVFFHFNPKLCVSTINQLLPML 781
            :.|..|.|: ..:...|:.|.|||::|.:||. ....:.|::|.:|||.|.|||:|.|.::..:.
Zfish   407 RKLRIIHGE-TQEVGNYSFYALDNQNLRQLWDWSKHNLTIQQGRMFFHHNSKLCMSEIRRMEEVT 470

  Fly   782 ASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKD 846
            .:|.: ..|:|:.:.:||::.||.:.||..|..|..::..::    |.|...|          .|
Zfish   471 GTKNR-QTKNDIVSKTNGDQASCESKVLKFTRISTLSDKIII----KWEAFWP----------PD 520

  Fly   847 PRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKVSSPE-----------KSGVMVLSNLIPYTN 898
            .|..:||:..:...||.|.|: ...|.| .:.|.::..:           :.|.::.. |.|:|.
Zfish   521 FRDLLGFMVLYKEAPYKNVTEFDGQDACGSNSWVIADVDPPPRATEGKEHEPGYLIFP-LKPWTQ 584

  Fly   899 YSYYVRTMAISS---ELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLT 960
            |:..|:|...:|   ::..|:|::...|||..:||...:.::::.|.|:|.:.|...:.|.|.:|
Zfish   585 YAIMVKTQLSASDEHQVHGAKSEIIYVRTNATKPSVPLDPISSSNSSSQIILKWKPPNDPNGNIT 649

  Fly   961 RYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISD------------PLAGDCKCV 1013
            .|.:..:.....:.....|||.    |.|:  ||...||:..::            |.:..|.|.
Zfish   650 HYLVFCQQQPEASELYKFDYCQ----KGMK--LPTRAPTQVDNEEEQKWNQTEEQGPDSRCCACP 708

  Fly  1014 EGSK--KTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKN-----GSSDKSDGAEGAALDSNA 1071
            :..|  |..::|.:.||.     |||.|.|.:|  .:|.|:.     |.::::  :.......::
Zfish   709 KTEKQLKKEAEETEYRKT-----FENYLHNEVF--ELRPSRQRRSLVGIANRT--SSRLFTTPSS 764

  Fly  1072 IPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQF 1136
            :|||.||.                                             ..||:..:||..
Zfish   765 LPNGSATR---------------------------------------------SPEEEAEANKIS 784

  Fly  1137 YEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTV-FQTTKR 1200
            ..|.|||      ..|...|||||.|.|.:.||..  .|:..|        ||....| .:|...
Zfish   785 LIVQAKE------STVISNLRHFTSYQIEIHACNH--GSDPTR--------CSMAAYVSARTMPE 833

  Fly  1201 KKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFN 1265
            :|..|||..:..::     .|..|.:||..|..|||.|:.|||.|| :..|..|...|:...::.
Zfish   834 EKADDIVGKITCEV-----FEYSVHIRWIEPKAPNGMIILYEVHYK-RLGDTEELHHCVSRKNYI 892

  Fly  1266 QTAGYLIK-LNEGLYSFRVRANSIAGYGDFTEVEHIKVE----PPPSYAKVFFWLLGIGLAFLIV 1325
            ...|..:: ::.|.|:.|:||.|:||.|.:||..|..|:    .|.:..|:   ::|..:.|.::
Zfish   893 ADGGCKLRVVHPGNYTVRIRATSLAGNGSWTEPTHFYVQDLRVDPSNVLKI---VIGPVICFFLL 954

  Fly  1326 SLFGYVCYLHKRKV---PSNDLHMNTEVNPFYASMQ--YIPDDWEVLRENIIQLAPLGQGSFGMV 1385
            .|.....|:.|:|.   |:..|:  |..||.|.|..  |.||:|||.||.|..|..|||||||||
Zfish   955 LLLCVGFYIVKKKQTEGPTGRLY--TSPNPEYFSPDEVYEPDEWEVPREKITLLRELGQGSFGMV 1017

  Fly  1386 YEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVV 1450
            |||..|...........|:|||||:|:.|||..||:||||||.|..:||||||||.|:|||.|||
Zfish  1018 YEGNGKDIVKGESQTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLVV 1082

  Fly  1451 MELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKF 1515
            ||||..|||||:||:.||:..:..            ...|||...:.|||.|||||||||.||||
Zfish  1083 MELMTHGDLKSFLRSLRPDSENNP------------GRPPPTLKEMIQMAAEIADGMAYLNAKKF 1135

  Fly  1516 VHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVF 1580
            |||||||||||||:||||||||||||||||||||||||.|||||||||.||||:|||:::.||.:
Zfish  1136 VHRDLAARNCMVAEDLTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCW 1200

  Fly  1581 SFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLD 1645
            ||||||||::|||.||||||||||||::|::||.::||:||.|.||.|||.|||:....||:|.:
Zfish  1201 SFGVVLWEVSTLAEQPYQGLSNEQVLKFVMEGGYLDRPDNCADRLHNLMQMCWHYNPKMRPTFQE 1265

  Fly  1646 IIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLR 1710
            ||..|.... :..|:||||::||   :::..|.:|           .|.||::.|     :.||.
Zfish  1266 IIEMLREDL-HPSFQEVSFFYSE---ENKPPETEE-----------FDMDLENME-----SIPLD 1310

  Fly  1711 MGDY-QQNSSLDQPPESPIAMVDDQGSHLPFSLPSG--------FIASSTP 1752
            ...| |:...||....|.:.:......|:|::..:|        .:..|||
Zfish  1311 PSSYSQRECCLDGDEGSSVGLRGSYEEHVPYTHMNGGKKNGRILSLPRSTP 1361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382 61/111 (55%)
Furin-like 512..645 CDD:279142 48/138 (35%)
FU 545..592 CDD:238021 20/47 (43%)
Recep_L_domain 663..781 CDD:279382 42/118 (36%)
FN3 1224..1302 CDD:238020 29/78 (37%)
PTKc_InsR_like 1364..1652 CDD:173625 186/287 (65%)
Pkinase_Tyr 1371..1650 CDD:285015 180/278 (65%)
insraXP_005171317.1 Recep_L_domain 53..165 CDD:279382 61/111 (55%)
Furin-like 179..337 CDD:279142 56/169 (33%)
FU 234..281 CDD:238021 20/47 (43%)
Recep_L_domain 356..470 CDD:279382 42/118 (36%)
FN3 618..>660 CDD:238020 10/41 (24%)
FN3 851..930 CDD:238020 29/79 (37%)
PTKc_InsR 996..1283 CDD:133192 189/299 (63%)
Pkinase_Tyr 1003..1270 CDD:285015 180/278 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 358 1.000 Domainoid score I923
eggNOG 1 0.900 - - E2759_KOG4258
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 795 1.000 Inparanoid score I489
OMA 1 1.010 - - QHG49983
OrthoDB 1 1.010 - - D120934at33208
OrthoFinder 1 1.000 - - FOG0001171
OrthoInspector 1 1.000 - - otm24447
orthoMCL 1 0.900 - - OOG6_103219
Panther 1 1.100 - - LDO PTHR24416
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4609
SonicParanoid 1 1.000 - - X893
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1514.870

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