DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Met

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_113705.2 Gene:Met / 24553 RGDID:3082 Length:1382 Species:Rattus norvegicus


Alignment Length:1448 Identity:312/1448 - (21%)
Similarity:491/1448 - (33%) Gaps:543/1448 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   542 EHTCC--SQDC------LGG---------CVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDS 589
            ||..|  .|||      .||         .::|...::..|||.:|:     ..:|.:.....|:
  Rat    91 EHPDCFPCQDCSSKANVSGGVWKDNVNMALLVDTYYDDQLISCGSVN-----RGTCQRHVLPPDN 150

  Fly   590 RCVTANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCP----GGKCDKECSSG 650
            .....:|                       .||.......|....|..|.    |.|.       
  Rat   151 AADIQSE-----------------------VHCMFSPLAEEESGQCPDCVVSALGAKV------- 185

  Fly   651 LIDSLERAREFH-GCTIITGTEP----LTISIKR-------------ESGAHVMDELK--YGLAA 695
            |:...:|...|. |.||.:...|    .:||::|             :|...|:.|.:  |.:..
  Rat   186 LLSEKDRFINFFVGNTINSSYPPDYSLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKY 250

  Fly   696 VHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGG 760
            :|..:|:   |..|.|...|           ..:||..:...::....:|             .|
  Rat   251 IHAFESN---HFIYFLTVQK-----------ETLDAQTFHTRIIRFCSVD-------------SG 288

  Fly   761 VFFHFN-PKLCVST------------INQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVT 812
            :..:.. |..|:.|            .|.|.....|||.......:||....:           .
  Rat   289 LHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGASPYDD-----------I 342

  Fly   813 LQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDP---------YGNSTKS 868
            |..|.|.|       |.:..||.   |.:.|...|..::...|..:::.         ||    .
  Rat   343 LYGVFAQS-------KPDSAEPM---NRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYG----P 393

  Fly   869 SDDPCDDRWKVSSPEKSGVMVLS---------------------NLIPYTNYSYYVRTMAISSEL 912
            :.:.|.:|..:.:  .||..|.|                     |.:..|:.|.:::     .:|
  Rat   394 NHEHCFNRTLLRN--SSGCEVRSDEYRTEFTTALQRVDLFMGRLNHVLLTSISTFIK-----GDL 451

  Fly   913 TNAESDVKNFRTNPGR---------------------------------PS------------KV 932
            |     :.|..|:.||                                 ||            |:
  Rat   452 T-----IANLGTSEGRFMQVVLSRTAHFTPHVNFLLDSYPVSPEVIVEHPSNQNGYTLVVTGKKI 511

  Fly   933 TEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATT 997
            |::....:...........|..|      |||:.            .:|....|.:  |:.|:.|
  Rat   512 TKIPLNGLGCGHFQSCSQCLSAP------YFIQC------------GWCHNRCVHS--NECPSGT 556

  Fly   998 PTKKI-----------SDPLAGD-----CKCVEGSKKTSSQEYDDRKVQAGME---------FEN 1037
            .|::|           |.||.|.     |....|.||.:..:....||..|.|         ..|
  Rat   557 WTQEICLPAVYKVFPTSAPLEGGTMLTICGWDFGFKKNNKFDLRKTKVLLGNESCTLTLSESTTN 621

  Fly  1038 AL---------QNF---IFVPNIRKSKNGS------------SDKSDGAEGAAL----------- 1067
            .|         ::|   :.|.|.|::...|            |.:.....|..|           
  Rat   622 TLKCTVGPAMSEHFNVSVIVSNSRETTQYSAFSYVDPVITSISPRYGPHAGGTLLTLTGKYLNSG 686

  Fly  1068 DSNAIPNGGATNPSRRRRD-----------------VALEPEL-DDVEGSVLLRH--VRSITDDT 1112
            :|..|..||.|...:...|                 |.|:.:| |.|..|...|.  |.|....|
  Rat   687 NSRHISIGGKTCTLKSVSDSILECYTPGHTVSAEFPVKLKIDLADRVTSSFSYREDPVVSEIHPT 751

  Fly  1113 DAFFEKDDENT--YKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPS 1175
            .:|.......|  .|:...:|:.|...||  .::..|.|                 |||:....|
  Rat   752 KSFISGGSTITGIGKNLNSVSTPKLVIEV--HDVGVNYT-----------------VACQHRSSS 797

  Fly  1176 EKLRDTSFKKSLCSDYDTVFQ-----TTKRKKF--ADIVMDLKVDLEHANNT-----ESPVRVRW 1228
            |         .:|....::.|     ..|.|.|  .|.::....||.:.::.     |.||.:..
  Rat   798 E---------IICCTTPSLQQLDLQLPLKTKAFFLLDGILSKHFDLTYVHDPMFKPFEKPVMISM 853

  Fly  1229 ---------TPPVDPNGEIVTYEVAYKLQKPDQVEEKKC-------------IPAADFNQTAGYL 1271
                     ...:||  |.|..||.       :|..|.|             :|:.        |
  Rat   854 GNENVVEIKGDDIDP--EAVKGEVL-------KVGNKSCENLHWHSEALLCTVPSD--------L 901

  Fly  1272 IKLNEGLYSFRVR---ANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCY 1333
            :|||.|..:...:   ::::.|        .:.|:|..::|.:....:.|.:..|:||  |...:
  Rat   902 LKLNGGELNIEWKQAVSSTVLG--------KVIVQPDQNFAGLIIGAVSISVVVLLVS--GLFLW 956

  Fly  1334 LHKRK-----------------------------VPSNDLHMN---------------------- 1347
            |.|||                             .|:.::..|                      
  Rat   957 LRKRKHKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGA 1021

  Fly  1348 --------TEVNPFYAS----------MQYIPDDWEVLRENIIQ------LAP----------LG 1378
                    |:::|...|          ...:..|...|...::|      :.|          :|
  Rat  1022 CRQVQYPLTDLSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIG 1086

  Fly  1379 QGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVC-- 1441
            :|.||.||.|.|  ...:|....||:|::|......|.:.||:|..:||:|...:|:.|||:|  
  Rat  1087 RGHFGCVYHGTL--LDSDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLR 1149

  Fly  1442 SRGQPALVVMELMKKGDLKSYLR--AHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIA 1504
            |.|.| |||:..||.|||::::|  .|.|..:|                       :....:::|
  Rat  1150 SEGSP-LVVLPYMKHGDLRNFIRNETHNPTVKD-----------------------LIGFGLQVA 1190

  Fly  1505 DGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYY----RKGTKGLLPVRWMPP 1565
            .||.|||:||||||||||||||:.:..|||:.|||:.||:|:.:||    :.|.|  |||:||..
  Rat  1191 KGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAK--LPVKWMAL 1253

  Fly  1566 ESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQ 1630
            |||:...:::.|||:||||:|||:.|..|.||..::...:..|::.|..:.:||.|||.|:::|.
  Rat  1254 ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVML 1318

  Fly  1631 RCWHHRSSARPSFLDIIA 1648
            :|||.::..||||.::::
  Rat  1319 KCWHPKAEMRPSFSELVS 1336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614 23/123 (19%)
Recep_L_domain 663..781 CDD:460032 26/149 (17%)
FN3 791..>964 CDD:442628 37/247 (15%)
FN3 1224..1302 CDD:238020 17/102 (17%)
PTKc_InsR_like 1364..1652 CDD:173625 114/309 (37%)
MetNP_113705.2 Sema 25..517 CDD:472829 89/524 (17%)
PSI 520..562 CDD:214655 11/61 (18%)
IPT_plexin_repeat1 564..657 CDD:238585 19/92 (21%)
IPT_plexin_repeat2 658..741 CDD:238584 15/82 (18%)
IPT 743..838 CDD:472823 25/122 (20%)
IPT 839..>903 CDD:214657 14/80 (18%)
PTKc_Met_Ron 1083..1344 CDD:270649 111/282 (39%)
Interaction with RANBP9. /evidence=ECO:0000250 1213..1382 51/126 (40%)
Interaction with MUC20. /evidence=ECO:0000250 1321..1360 6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

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