Protein Alignment InR and Ephb1

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_001097998.1
• Gene: Ephb1 / 24338
• RGDID: 2556
• Length: 984
• Species: Rattus norvegicus
• Alignment Length: 1158
• Identity: 248/1158 - (21%)
• Similarity: 409/1158 - (35%)
• Gaps: 361/1158 - (31%)

  Fly   649 SGLIDSLERAREFHGCTIITGTEP------LTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHL 707
            ||..::|...|.:..|.:.   ||      ||..|.|.....:..|:::
  Rat    46 SGYDENLNTIRTYQVCNVF---EPNQNNWLLTTFINRRGAHRIYTEMRF---------------- 91

  Fly   708 TYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVS 772
                 :::...||..:.|.   ..:.:.||..:          ..:|...|...|:...|.|.|.
  Rat    92 -----TVRDCSSLPNVPGS---CKETFNLYYYE----------TDSVIATKKSAFWSEAPYLKVD 138

  Fly   773 TINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKP 837
            ||        :..:.|.:.|.|                         ..::.|.|:|....|...
  Rat   139 TI--------AADESFSQVDFG-------------------------GRLMKVNTEVRSFGPLTR 170

  Fly   838 SNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYY 902
            :...:.|:|               ||        .|             :.:||..:.:......
  Rat   171 NGFYLAFQD---------------YG--------AC-------------MSLLSVRVFFKKCPSI 199

  Fly   903 VRTMAISSE-LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKA 966
            |:..|:..| :|.|||               |.:|
  Rat   200 VQNFAVFPETMTGAES---------------TSLV------------------------------ 219

  Fly   967 KLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQA 1031
              |.|.|...|.:....|:......|.....|        .|.|.|                 :|
  Rat   220 --IARGTCIPNAEEVDVPIKLYCNGDGEWMVP--------IGRCTC-----------------KA 257

  Fly  1032 GMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDV 1096
            |.|.||::.       .:....|:...|..|||.:...:...:....:|....|......:.|..
  Rat   258 GYEPENSVA-------CKACPAGTFKASQEAEGCSHCPSNSRSPSEASPICTCRTGYYRADFDPP 315

  Fly  1097 EGSVLL-----RHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQ-------- 1148
            |.:...     |:|.||.::|....|..........:|::     |.:..|:...::
  Rat   316 EVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVT-----YNIICKKCRADRRSCSRCDD 375

  Fly  1149 -THFVFEKLRHFTRYAIFVVACREEIPS-----------EKLRDTSFKKSLCSDYDTVFQTTKRK 1201
             ..||..:|.        :..||..|.|           :.:...|.|......:.:|..||.:.
  Rat   376 NVEFVPRQLG--------LTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQA 432

  Fly  1202 KFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQ 1266
            ..:.:.:     :...:.|...:.:.|..|..|||.|:.||:.|..::.::..........:..:
  Rat   433 APSTVPI-----MHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTAR 492

  Fly  1267 TAGYLIKLNEGL-YSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLL-------------- 1316
            ..|    |..|: |..:|||.::||||.|:             .|:.|..|
  Rat   493 IDG----LRPGMVYVVQVRARTVAGYGKFS-------------GKMCFQTLTDDDYKSELREQLP 540

  Fly  1317 ------GIGLAFLIVSL--FGYVC----YLHKRKVPSNDLH----------MNTEVNPFYASMQY 1359
                  ..|:.| :|||  ...||    ...|..|.|:.|.          |...::||     .
  Rat   541 LIAGSAAAGVVF-VVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPF-----T 599

  Fly  1360 IPDDWEVLRE-------NIIQLAP-LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRER 1416
            ..|..|.:||       :.:::.. :|.|.||.||:|.||.  |...:...||||:....::::|
  Rat   600 YEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKL--PGKREIYVAIKTLKAGYSEKQR 662

  Fly  1417 TNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNR 1481
            .:||||||:|.:||..:::||.||.::.:|.:::.|.|:.|.|.|:||      :::...|.:..
  Rat   663 RDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLR------QNDGQFTVIQL 721

  Fly  1482 IGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---D 1543
            :|               |...||.||.||:...:|||||||||.:|..:|..|:.|||::|   |
  Rat   722 VG---------------MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQD 771

  Fly  1544 IYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRY 1608
            ......|.....|.:||||..||::....::|||||:|:|:|:||:.:...:||..:||:.|:..
  Rat   772 DTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINA 836

  Fly  1609 VIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPN-SQFKEVSFYHSEAGLQ 1672
            :.....:..|.:||..||:||..||....::||.|.:|:..|:....| :..|.|:
  Rat   837 IEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVA--------- 892

  Fly  1673 HREKERKERNQLDAFAAVPLDQDLQDRE--------QQEDATTPLRMGDYQQN 1717
                         ...||| .|.|.||.        ..:|..:.::|..|:.:
  Rat   893 -------------TITAVP-SQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDS 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032	21/123 (17%)
		FN3	791..>964	CDD:442628	22/173 (13%)
		FN3	1224..1302	CDD:238020	21/78 (27%)
		PTKc_InsR_like	1364..1652	CDD:173625	102/298 (34%)
Ephb1	NP_001097998.1	EphR_LBD_B1	20..195	CDD:198444	39/254 (15%)
		fn3	326..412	CDD:394996	16/98 (16%)
		fn3	435..518	CDD:394996	21/91 (23%)
		EphA2_TM	542..616	CDD:464211	18/79 (23%)
		PTKc_EphR_B	614..882	CDD:173638	99/290 (34%)
		SAM_EPH-B1	908..975	CDD:188950	3/24 (13%)
		PDZ-binding. /evidence=ECO:0000255	982..984