DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and Insrr

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	XP_006501514.1	Gene:	Insrr / 23920	MGIID:	1346037	Length:	1313	Species:	Mus musculus

Alignment Length:	1411	Identity:	503/1411 - (35%)
Similarity:	718/1411 - (50%)	Gaps:	221/1411 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---LNRSFPKLTEVTDYIIIYRVTGLHSL 400
            |.|:|||:.|:...:||||:|:||.|.|.|:..|:.   ...|||:||:||||::::||.||.||
Mouse    30 CPSLDIRSEVTELRRLENCSVVEGHLQILLMFAATGEDFRGLSFPRLTQVTDYLLLFRVYGLESL 94

  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465
            ..:||||:||||.:||.||||:::....|.|:||..|.::.||.||:|||.:||:..||||..:.
Mouse    95 RDLFPNLTVIRGTRLFLGYALIIFEMPHLRDVGLPSLGAVLRGAVRVEKNQELCHLSTIDWGLLQ 159

  Fly   466 AENETQLVVLTENGKEKECRLSKCPGEI-RIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQT 529
            ....|..:|..:.|  :|| ...|||.: ...|....|...|..:..         ||.|..||.
Mouse   160 PAPGTNHIVGNKLG--EEC-ADVCPGVLGAAGEPCSRTTFSGRTDYR---------CWTSSHCQK 212

  Fly   530 KCPEKCRNNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFDS-RCVT 593
            .||......|.....||..:||||| .......:|::||::.|..:|:.:||.|.||::| ||||
Mouse   213 VCPCPRGMACTAGGDCCHSECLGGC-SQPEDPRACVACRHLYFQGVCLRACPPGTYQYESWRCVT 276

  Fly   594 ANECITLTKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSG--LIDSLE 656
            |..|..|.:....:...|| |.|.|:..||.|:.::.:...|..|. |.|.|||..|  .|||::
Mouse   277 AELCAHLREVPGLATTFGI-YEGSCLAQCPPGFTRNGSSIFCHKCE-GLCPKECKVGTKTIDSVQ 339

  Fly   657 RAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLT 721
            ..::..|||.:.|.  |.:::::  |.::..||:..|..|..|...|.:..::.|.:|.||::|.
Mouse   340 ATQDLVGCTHVEGN--LILNLRQ--GYNLEPELQRNLGLVETITGFLKIKHSFALVTLGFFKNLK 400

  Fly   722 EISGDPPMDADKYALYVLDNRDLDEL--WGPNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASK 784
            .|.||..:|.: |.||||||::|.:|  | ....:.|..|.::|.|||:||:..|.||..:..::
Mouse   401 LIRGDSMVDGN-YTLYVLDNQNLQQLGSW-VTAGLTIPVGKIYFAFNPRLCLEHIYQLEEVTGTR 463

  Fly   785 PKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEI---GEPQKPSNATIVFKD 846
            .: ..|:::...:||:|.:|.|..|..          :.|:|.:..|   .|..:|..|
Mouse   464 GR-QSKAEINPRTNGDRAACQTRTLRF----------VFNLTEEDRILLRWERYEPLEA------ 511

  Fly   847 PRAFIGFVFYHMIDPYGNSTKS-SDDPCDDR-WK-------VSSPEKSGVMVLSNLIPYTNYSYY 902
             |..:.|:.|:...|:.|:|:. ..|.|..: |.       :|..::.|| .|:.|.|:|.|:.:
Mouse   512 -RDLLSFIVYYKESPFQNATEHVGPDACGTQSWNLLDVELPLSRTQEPGV-TLAPLKPWTQYAVF 574

  Fly   903 VR----TMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYF 963
            ||    |.|..|....|:|.:...||.|..|:...:|::|:.|.|.:.|.|....:..|.:|.|.
Mouse   575 VRAITLTTAEDSPHQGAQSPIVYLRTLPAAPTVPQDVISTSNSSSHLLVRWKPPVQRNGNITYYL 639

  Fly   964 IKAKLINRPTRNNN---RDYCTEPLVKAMENDLPATTPTKKI--------SDPLAGDCKCVEGSK 1017
            :   |..|...:.:   .|||...|      .||.::...:.        ::|..|.|.|.....
Mouse   640 V---LWQRLAEDGDLYINDYCHRGL------RLPTSSHDTRFDREDPALEAEPEQGCCPCQHSPP 695

  Fly  1018 KTSSQEYDDRKVQAGMEFENALQNFIFVP-------NIRKSKNGSSDKSDGAEGAALDSNAIPNG 1075
            ..:....:.::|....:|||.|.:.|.:|       :|.|:....|:
Mouse   696 GQALPALEAQEVTFQKKFENFLHHAITIPKAPWKVTSINKNPQRDSE------------------ 742

  Fly  1076 GATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVF 1140
                  |.||:..            |||                          |..|...:|:.
Mouse   743 ------RHRREAG------------LLR--------------------------LGKNNSDFEIQ 763

  Fly  1141 AKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFAD 1205
            ..::|..:.  :...|||||.|.|.:.||.....:..          ||....||..|...:.||
Mouse   764 EDKVPRERA--ILSGLRHFTEYRIDIHACNHAAHTVG----------CSAATFVFARTMPHREAD 816

  Fly  1206 IVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKK---CIPAADFNQT 1267
            .:.. ||..:.|.  :|.|.:.|..|.||||.|:.||:.|:     ::.|:.   |:....:.:.
Mouse   817 GIPG-KVAWKAAG--KSSVTLHWLEPPDPNGLILKYEIKYR-----RLGEEATVLCVSRLRYAKV 873

  Fly  1268 AG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKV----EPPPSYAKVFFWLLGIGLAFLIVSL 1327
            .| :|..|..|.||.:|||.|:||.|.:|:.....:    |......::|..:..:|  |:::..
Mouse   874 GGVHLALLPPGNYSAKVRATSLAGNGSWTDGVTFYITDLEEEDTGGMRIFLTVTPVG--FMLLVT 936

  Fly  1328 FGYVCYLHKRKVPSNDLHMNTEVNP--FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGIL 1390
            ...:.:.:.||..|.   :.|.|||  |.||..|:||:|||.||.|..:..||||||||||||:.
Mouse   937 LAALGFFYSRKRNST---LYTSVNPEYFSASHMYVPDEWEVPREQIAIIRELGQGSFGMVYEGLA 998

  Fly  1391 KSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHV-------------VRLLGVCS 1442
            :...........|:|||||.|:.|||..||.||||||.|..:||             ||||||.|
Mouse   999 RGLEAGEESTPVALKTVNELASARERVEFLKEASVMKAFKCHHVRQEGLPQRSLSSQVRLLGVVS 1063

  Fly  1443 RGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGM 1507
            :|||.||:||||.:|||||:||:.|||..:..            .:..|....:.|||.||||||
Mouse  1064 QGQPTLVIMELMTRGDLKSHLRSLRPEAENNP------------GLPQPALSDMIQMAGEIADGM 1116

  Fly  1508 AYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGV 1572
            ||||||||||||||||||||:.|.||||||||||||:|||||||||.|||||||||.||||:||:
Mouse  1117 AYLAAKKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGI 1181

  Fly  1573 YSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRS 1637
            :::.|||:||||||||:.|||.||||||||||||::|:||||:|..||||..|.:||:.||.|..
Mouse  1182 FTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELENCPIQLQELMRLCWQHSP 1246

  Fly  1638 SARPSFLDIIAYLEPQCPNSQFKEVSFYHS------EAGLQHREKE 1677
            ..||:|:.|:..::.:...| |:..|||:|      :|.|...|.|
Mouse  1247 RLRPTFVHILDRIQDELRPS-FRLCSFYYSPECQRGQASLLPTEAE 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382	56/111 (50%)
		Furin-like	512..645	CDD:279142	45/133 (34%)
		FU	545..592	CDD:238021	19/47 (40%)
		Recep_L_domain	663..781	CDD:279382	42/119 (35%)
		FN3	1224..1302	CDD:238020	27/81 (33%)
		PTKc_InsR_like	1364..1652	CDD:173625	178/300 (59%)
		Pkinase_Tyr	1371..1650	CDD:285015	173/291 (59%)
Insrr	XP_006501514.1	Recep_L_domain	47..157	CDD:366426	56/109 (51%)
		Furin-like	173..329	CDD:366287	56/170 (33%)
		Recep_L_domain	346..459	CDD:366426	42/118 (36%)
		FN3	494..600	CDD:238020	29/113 (26%)
		FN3	605..>649	CDD:238020	12/46 (26%)
		FN3	819..908	CDD:238020	31/96 (32%)
		PTKc_InsR_like	972..1261	CDD:173625	178/300 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	364	1.000	Domainoid score	I936
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	812	1.000	Inparanoid score	I477
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49983
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001171
OrthoInspector	1	1.000	-	-		otm43953
orthoMCL	1	0.900	-	-		OOG6_103219
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X893
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830