DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and ALK

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_004295.2 Gene:ALK / 238 HGNCID:427 Length:1620 Species:Homo sapiens


Alignment Length:770 Identity:199/770 - (25%)
Similarity:307/770 - (39%) Gaps:217/770 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1302 VEPPPSYAKVFFWLLGIGLAFLIVSL---FGYVCYLHKRK----------VPSNDLHMN------ 1347
            |.|.|........:|.:..:.|:.:|   |..:..:::||          :.|.:..::      
Human  1023 VSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTST 1087

  Fly  1348 --TEVNP---FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTV 1407
              |:.||   |......|.|..||.|:||..:..||.|:||.||||.:...|.:....:.|:||:
Human  1088 IMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL 1152

  Fly  1408 NENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERD 1472
            .|..::::..:||.||.::.:|:..::||.:||..:..|..:::|||..|||||:||..||....
Human  1153 PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQ 1217

  Fly  1473 EAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMV---ADDLTVK 1534
            .:.:..|:               :..:|.:||.|..||....|:|||:|||||::   ......|
Human  1218 PSSLAMLD---------------LLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAK 1267

  Fly  1535 IGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQG 1599
            ||||||.||||...|||||...:|||:|||||:..:|:::|.:|.:||||:|||:.:|...||..
Human  1268 IGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPS 1332

  Fly  1600 LSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE-----PQCPNSQF 1659
            .||::||.:|..||.|:.|:|||..::::|.:||.|:...||:|..|:..:|     |...|:  
Human  1333 KSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINT-- 1395

  Fly  1660 KEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSLDQPP 1724
                                         |:|::......|:::   .|:|..|         |.
Human  1396 -----------------------------ALPIEYGPLVEEEEK---VPVRPKD---------PE 1419

  Fly  1725 ESPIAMVDDQGSHLPFSLPSGFIASSTPDGQTVMATAFQNIPAAQGDISATYVVPDADALDGDRG 1789
            ..|..:|..|...                       ..:..|||                     
Human  1420 GVPPLLVSQQAKR-----------------------EEERSPAA--------------------- 1440

  Fly  1790 YEIYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPRKGRQPTIMSSSMPDDVIGGSSLQPSTASAG 1854
                 |.|    |||:.||               :..::||....|:  .|..|    |:.....
Human  1441 -----PPP----LPTTSSG---------------KAAKKPTAAEISV--RVPRG----PAVEGGH 1475

  Fly  1855 SSNASSHTGRPSLKKTVADSVRNKANFINRHLFNHKRTGSNASHKSNASNAPSTSSNTNLTSHPV 1919
            .:.|.|.:..||....|..| |||...:           .|.::.|..:..|:..:|......|.
Human  1476 VNMAFSQSNPPSELHKVHGS-RNKPTSL-----------WNPTYGSWFTEKPTKKNNPIAKKEPH 1528

  Fly  1920 AMGNLGTIESGGSGSAGSYTGTPRFYTPSATPGGGSGMAISDNPNYRLLDESIASEQATILTTSS 1984
            ..||||.        .||.|..|...|.                  ||...|:..|.:::.....
Human  1529 DRGNLGL--------EGSCTVPPNVATG------------------RLPGASLLLEPSSLTANMK 1567

  Fly  1985 PNPNYEMMHPPTSLVSTNPNY------MPMNETPVQMAG-----VTISHNPNYQP 2028
            ..|.:.:.|.|..    |.||      :|:.......||     :..|.|...||
Human  1568 EVPLFRLRHFPCG----NVNYGYQQQGLPLEAATAPGAGHYEDTILKSKNSMNQP 1618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 199/770 (26%)
PTKc_InsR_like 1364..1652 CDD:173625 115/295 (39%)
ALKNP_004295.2 Heparin-binding region. /evidence=ECO:0000269|PubMed:34646012 48..70
MAM 266..424 CDD:99706
LDLa 441..467 CDD:197566
MAM 480..635 CDD:459878
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..674
EGF-like. /evidence=ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673 987..1025 1/1 (100%)
FXa_inhibition 987..1021 CDD:464251
PTKc_ALK_LTK 1109..1385 CDD:270632 114/290 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1408..1463 19/134 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1514..1540 9/33 (27%)
Blue background indicates that the domain is not in the aligned region.

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