DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and FLT3

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_004110.2 Gene:FLT3 / 2322 HGNCID:3765 Length:993 Species:Homo sapiens


Alignment Length:1026 Identity:227/1026 - (22%)
Similarity:374/1026 - (36%) Gaps:285/1026 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   813 LQSVGANSAMLNVTTKVEIGE-----PQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDP 872
            ||:.|..|.::...|:.:.||     ..:.:|.||:|                            
Human   120 LQNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILF---------------------------- 156

  Fly   873 CDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAESDVKNFRTNPGRPSKVTE-VV 936
                          .:.:.|.:.||....|.|.|.....|......|         |..:.| |:
Human   157 --------------TVSIRNTLLYTLRRPYFRKMENQDALVCISESV---------PEPIVEWVL 198

  Fly   937 ATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTK- 1000
            ..:..:|....:.:.:.|...||...|  ...|....||.....||. |.....|..|.||..: 
Human   199 CDSQGESCKEESPAVVKKEEKVLHELF--GTDIRCCARNELGRECTR-LFTIDLNQTPQTTLPQL 260

  Fly  1001 --KISDPLAGDCKCVEGSKKTS-SQEYDDRKVQAGMEFENALQN---------FIFVPNIRKSKN 1053
              |:.:||...||.|..:.... :.|.:::.::.|..||.:..:         |.||.::.::..
Human   261 FLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARNDT 325

  Fly  1054 G----SSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDA 1114
            |    ||.|                    :||:                |.|:..|         
Human   326 GYYTCSSSK--------------------HPSQ----------------SALVTIV--------- 345

  Fly  1115 FFEKDDENTYKDEEDLSSNKQFYEVFA-----KELPPNQTHFVFEKLRHFTRYAIFVVACREEIP 1174
              ||...|.....||...::  ||.|.     |..|..:..:.|.               |:..|
Human   346 --EKGFINATNSSEDYEIDQ--YEEFCFSVRFKAYPQIRCTWTFS---------------RKSFP 391

  Fly  1175 SEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIV 1239
            .|       :|.|.:.|..       .||.:........:.||.|.::.....:|..:....:::
Human   392 CE-------QKGLDNGYSI-------SKFCNHKHQPGEYIFHAENDDAQFTKMFTLNIRRKPQVL 442

  Fly  1240 T---------YEVAYKL----------QKPDQVEEKKCIPAADFNQTA----------GYLIKLN 1275
            .         :...|.|          :.|:..||   |....:|:.|          ...:.::
Human   443 AEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEE---ITEGVWNRKANRKVFGQWVSSSTLNMS 504

  Fly  1276 EGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKV-----FFWLLGIGLAFLIVSLFGYVCYLH 1335
            |.:..|.|:..:....|  |..|.|.:..|..:..:     |:..:|:.|.|::| |...:|:.:
Human   505 EAIKGFLVKCCAYNSLG--TSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVV-LTLLICHKY 566

  Fly  1336 KRKVP-SNDLHM-----NTEVNPFYASMQYIPDD--WEVLRENIIQLAPLGQGSFGMVYEGILKS 1392
            |::.. .:.|.|     :::...||...:....|  ||..|||:.....||.|:||.|.......
Human   567 KKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYG 631

  Fly  1393 FPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKK 1456
            ....||..:.|:|.:.|.|...||...:||..:|.:..:: ::|.|||.|:...|..::.|....
Human   632 ISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCY 696

  Fly  1457 GDLKSYLRAHR------------------------------PEERDEAMMTYLNRI-GVTGN--- 1487
            |||.:|||:.|                              |..|:..:....::| |:.||   
Human   697 GDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFH 761

  Fly  1488 ------------------VQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVK 1534
                              :...|:..:...|.::|.||.:|..|..|||||||||.:|.....||
Human   762 SEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVK 826

  Fly  1535 IGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQG 1599
            |.|||:.|||.....|.......|||:||.||||.:|:|:..|||:|:|::|||:.:|...||.|
Human   827 ICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 891

  Fly  1600 LS-NEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVS 1663
            :. :....:.:.:|..|::|....:.::.:||.||...|..||||.::.::|..|..::   |.:
Human   892 IPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADA---EEA 953

  Fly  1664 FYHSEAG----LQHREKERKERNQLDAFAAVPLDQD-----LQDREQQEDA 1705
            .|.:..|    ..|..:.|:           |..::     |..:.|.||:
Human   954 MYQNVDGRVSECPHTYQNRR-----------PFSREMDLGLLSPQAQVEDS 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 26/156 (17%)
FN3 1224..1302 CDD:238020 16/106 (15%)
PTKc_InsR_like 1364..1652 CDD:173625 105/341 (31%)
FLT3NP_004110.2 ig 256..345 CDD:395002 22/124 (18%)
Ig strand B 268..272 CDD:409448 1/3 (33%)
Ig strand C 282..286 CDD:409448 0/3 (0%)
Ig strand E 314..317 CDD:409448 1/2 (50%)
Ig strand F 327..332 CDD:409448 0/4 (0%)
Ig strand G 340..343 CDD:409448 1/2 (50%)
Protein Kinases, catalytic domain 572..947 CDD:473864 110/374 (29%)
Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of bound ligand 591..597 1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

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