DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and FLT1

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_002010.2 Gene:FLT1 / 2321 HGNCID:3763 Length:1338 Species:Homo sapiens


Alignment Length:1274 Identity:274/1274 - (21%)
Similarity:460/1274 - (36%) Gaps:421/1274 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   778 LPMLASKPKFFEKSDVGADSNGNRGS--CGTAVLNVTLQSVGANSAMLNVT-------TKVEIGE 833
            ||.:.||..  |:..:...:.|..|.  |.|..|         |:|..|.|       ..|...:
Human    63 LPEMVSKES--ERLSITKSACGRNGKQFCSTLTL---------NTAQANHTGFYSCKYLAVPTSK 116

  Fly   834 PQKPSNATIVF--KDPRAFIGFVFYHMIDPYGNSTKSSD--DPCDDRWKVSSPEKSGVM---VLS 891
            .::..:|..:|  ...|.|:  ..|..|....:.|:..:  .||    :|:||..:..:   .|.
Human   117 KKETESAIYIFISDTGRPFV--EMYSEIPEIIHMTEGRELVIPC----RVTSPNITVTLKKFPLD 175

  Fly   892 NLIP--------------YTNYSY---------------YVRTMAISSELTNAESDVKNFRTNPG 927
            .|||              .:|.:|               ..:|..::...||...||   :.:..
Human   176 TLIPDGKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDV---QISTP 237

  Fly   928 RPSK-------VTEVVATAISDSKINVTWSYLDKP--------------------YGVLT----- 960
            ||.|       |....||...::::.:||||.|:.                    |.|||     
Human   238 RPVKLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQ 302

  Fly   961 ----------------------------RYFIKAKLINR---PTRNNNRDYCTEPLVKA------ 988
                                        :.||..|...:   .|....|.|.....|||      
Human   303 NKDKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPSPEV 367

  Fly   989 --MENDLPATTPT------------KKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGME---FE 1036
              :::.||||..:            |.:::..||:...:...|:::..:.....:...::   :|
Human   368 VWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYE 432

  Fly  1037 NALQNF--------------------IFVPNIR-----KSKNGSSDK----SDGAEGAALDSNAI 1072
            .|:.:|                    |..|.|:     .:.|.|..:    |:..|...||::: 
Human   433 KAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDFCSNNEESFILDADS- 496

  Fly  1073 PNGGATNPSRRRRDVALEPELDDVEGSVLL----------------------RHVRSITDDTDAF 1115
             |.|....|..:|...:|.:  :...|.|:                      |::.....|....
Human   497 -NMGNRIESITQRMAIIEGK--NKMASTLVVADSRISGIYICIASNKVGTVGRNISFYITDVPNG 558

  Fly  1116 FEKDDENTYKDEEDL----SSNKQFYE----VFAKELPPNQTHFVFEKLR------HFTRYAIFV 1166
            |..:.|....:.|||    :.||..|.    :..:.:.....|:...|.:      |.....:.:
Human   559 FHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTMHYSISKQKMAITKEHSITLNLTI 623

  Fly  1167 V----------ACR-------EEIPSEK---LRDTSFKKSL--CSDYDTVFQTTKRKKFADIVMD 1209
            :          |||       |||..:|   :||......|  .||:.....::       ..:|
Human   624 MNVSLQDSGTYACRARNVYTGEEILQKKEITIRDQEAPYLLRNLSDHTVAISSS-------TTLD 681

  Fly  1210 LKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKP--------------DQVEEKKCIP 1260
            .     |||....| ::.|            ::..:|:|:.              ::|.|:    
Human   682 C-----HANGVPEP-QITW------------FKNNHKIQQEPGIILGPGSSTLFIERVTEE---- 724

  Fly  1261 AADFNQTAGYLIKLNEGLYSFRVRAN----------SIAGYGDFTEVEHIKVEPPPSYAKVFFWL 1315
                          :||:|..:....          ::.|..|.:.:|.|.: .....|...|||
Human   725 --------------DEGVYHCKATNQKGSVESSAYLTVQGTSDKSNLELITL-TCTCVAATLFWL 774

  Fly  1316 LGIGLAFLIVSLFGYVCYLHKRKVPSNDLH-------MNTEVNPFYASMQYIPDD---WEVLREN 1370
            |        ::||     :.|.|..|:::.       |:.:..|.....:.:|.|   ||..||.
Human   775 L--------LTLF-----IRKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARER 826

  Fly  1371 IIQLAPLGQGSFGMVYE----GILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDT 1431
            :.....||:|:||.|.:    ||.||    ...|..|:|.:.|.||..|....::|..::.....
Human   827 LKLGKSLGRGAFGKVVQASAFGIKKS----PTCRTVAVKMLKEGATASEYKALMTELKILTHIGH 887

  Fly  1432 Y-HVVRLLGVCSR-GQPALVVMELMKKGDLKSYLRAHRP------------EERDEAMMTYLNR- 1481
            : :||.|||.|:: |.|.:|::|..|.|:|.:||::.|.            |.:.|.|...|.: 
Human   888 HLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQG 952

  Fly  1482 -----IGVTGN---------------------------VQPPTYGRIYQMAIEIADGMAYLAAKK 1514
                 ..||.:                           .:|.|...:...:.::|.||.:|:::|
Human   953 KKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRK 1017

  Fly  1515 FVHRDLAARNCMVADDLTVKIGDFGMTRDIYET-DYYRKG-TKGLLPVRWMPPESLRDGVYSSAS 1577
            .:||||||||.:::::..|||.|||:.||||:. ||.||| |:  ||::||.|||:.|.:||:.|
Human  1018 CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTR--LPLKWMAPESIFDKIYSTKS 1080

  Fly  1578 DVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARP 1641
            ||:|:||:|||:.:|...||.|:. :|.....:.:|..|..||.....::::|..|||.....||
Human  1081 DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPKERP 1145

  Fly  1642 SFLDIIAYL------------EPQCP-------NS-------QFKEVSFYHSEAGLQHREKERKE 1680
            .|.:::..|            :...|       ||       .|.|..|..|.:..:.......:
Human  1146 RFAELVEKLGDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISAPKFNSGSSDD 1210

  Fly  1681 RNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSS 1719
            ...::||..:.|::.....|...:||:  ...|||.:||
Human  1211 VRYVNAFKFMSLERIKTFEELLPNATS--MFDDYQGDSS 1247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032 2/2 (100%)
FN3 791..>964 CDD:442628 48/277 (17%)
FN3 1224..1302 CDD:238020 12/101 (12%)
PTKc_InsR_like 1364..1652 CDD:173625 111/353 (31%)
FLT1NP_002010.2 IG_like 143..219 CDD:214653 12/79 (15%)
IgI_VEGFR 230..330 CDD:409448 17/102 (17%)
Ig strand A 230..234 CDD:409448 2/6 (33%)
Ig strand A' 240..244 CDD:409448 1/3 (33%)
Ig strand B 246..255 CDD:409448 1/8 (13%)
Ig strand C 262..267 CDD:409448 1/4 (25%)
Ig strand C' 270..272 CDD:409448 1/1 (100%)
Ig strand D 275..283 CDD:409448 0/7 (0%)
Ig strand E 290..298 CDD:409448 3/7 (43%)
Ig strand F 308..314 CDD:409448 0/5 (0%)
Ig strand G 319..325 CDD:409448 0/5 (0%)
IgI_VEGFR-1 333..424 CDD:409499 17/90 (19%)
Ig strand A 333..337 CDD:409499 2/3 (67%)
Ig strand A' 343..348 CDD:409499 1/4 (25%)
Ig strand B 353..361 CDD:409499 2/7 (29%)
Ig strand C 365..371 CDD:409499 0/5 (0%)
Ig strand C' 373..376 CDD:409499 1/2 (50%)
Ig strand D 382..386 CDD:409499 0/3 (0%)
Ig strand E 388..393 CDD:409499 0/4 (0%)
Ig strand F 401..410 CDD:409499 1/8 (13%)
Ig strand G 413..424 CDD:409499 0/10 (0%)
Ig_3 427..539 CDD:464046 19/115 (17%)
IG_like 568..640 CDD:214653 12/71 (17%)
Ig strand B 573..577 CDD:409353 1/3 (33%)
Ig strand C 586..594 CDD:409353 0/7 (0%)
Ig strand E 619..623 CDD:409353 0/3 (0%)
Ig strand F 633..638 CDD:409353 2/4 (50%)
I-set 661..748 CDD:400151 16/129 (12%)
Ig strand B 679..682 CDD:409353 0/2 (0%)
Ig strand C 691..695 CDD:409353 1/15 (7%)
Ig strand E 714..718 CDD:409353 0/3 (0%)
Ig strand F 728..733 CDD:409353 1/4 (25%)
PTKc_VEGFR1 819..1157 CDD:271109 111/343 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 940..982 5/41 (12%)
Blue background indicates that the domain is not in the aligned region.

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