DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and Epha10

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001243361.1 Gene:Epha10 / 230735 MGIID:3586824 Length:1007 Species:Mus musculus


Alignment Length:471 Identity:136/471 - (28%)
Similarity:206/471 - (43%) Gaps:74/471 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  1224 VRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL-YSFRVRANS 1287
            |.:.|..|| |.|...|....|:::..::.:.::..........|..:..|.... |.|::||  
Mouse   470 VSLSWREPV-PAGAPGTNSTEYEIRYYEKGQSEQTYSTVKTGAPAVTVTNLKPATRYVFQIRA-- 531

  Fly  1288 IAGYGDFTEVE----HIKVEPPPSYAK--------------VFFWLLGIGLAFLIVSLFGYVC-- 1332
             |..|...|.:    .|:|:.|...|.              ....||.:|....:::::...|  
Mouse   532 -ASPGPLWEAQSFSPSIEVQTPGEVAPGSRDQSPAVVVTVVTISALLVLGSVMSVLAIWRRPCDG 595

  Fly  1333 ------------YLHKRKVPSNDLHMNTEV--NPFYASMQYIPDDWEVLRENIIQLAPLGQGSFG 1383
                        |.| .|||:....::.:.  :|..|...:..   |:..:::.....||.|.||
Mouse   596 KGSGNAHDEEELYFH-FKVPTRRTFLDPQSCGDPLQAVHLFAK---ELDAKSVTLEKSLGAGRFG 656

  Fly  1384 MVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPAL 1448
            .:..|.|:.  |...:...|:.|:.:..:|.:|.:||:||..:.:||..|:|||.||.:||.|.:
Mouse   657 DLCCGCLQL--PGRQELPVAVHTLRDGCSDSQRLSFLAEALTLGQFDHSHIVRLEGVVTRGNPLM 719

  Fly  1449 VVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAK 1513
            :|.|.|..|.|..:||.|..|.....:|..|.                     .:|..|.||:..
Mouse   720 IVTEYMNLGALDDFLRHHEGELVAAQLMGLLP---------------------GLASAMKYLSEM 763

  Fly  1514 KFVHRDLAARNCMVADDLTVKIGDFGM-TRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSAS 1577
            .:|||.||||..:|:..|..||..||. .||..|..|  ....|..|..|..||:|:.|.:||||
Mouse   764 GYVHRGLAARRVLVSSGLLCKISGFGRGPRDRAEAVY--TTMSGRSPALWAAPETLQFGHFSSAS 826

  Fly  1578 DVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPS 1642
            ||:|||:|:||:.....:||..:|.:.|::.|.||..:..|.|||..||:||..||....|.||.
Mouse   827 DVWSFGIVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPSQLHRLMLECWQKDPSERPR 891

  Fly  1643 FLDIIAYL-----EPQ 1653
            |..|.:.|     ||:
Mouse   892 FSQIHSILSKMGQEPE 907

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 18/82 (22%)
PTKc_InsR_like 1364..1652 CDD:173625 102/293 (35%)
Epha10NP_001243361.1 EphR_LBD 35..210 CDD:470656
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..343
fn3 339..431 CDD:394996
FN3 451..551 CDD:238020 19/84 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..486 6/16 (38%)
EphA2_TM 569..641 CDD:464211 12/75 (16%)
Protein Kinases, catalytic domain 638..902 CDD:473864 102/288 (35%)
SAM_EPH-A10 928..997 CDD:188948
Blue background indicates that the domain is not in the aligned region.

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