DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment InR and LMTK2

DIOPT Version :9

Sequence 1:	NP_001138093.1	Gene:	InR / 42549	FlyBaseID:	FBgn0283499	Length:	2144	Species:	Drosophila melanogaster
Sequence 2:	NP_055731.2	Gene:	LMTK2 / 22853	HGNCID:	17880	Length:	1503	Species:	Homo sapiens

Alignment Length:	1027	Identity:	235/1027 - (22%)
Similarity:	367/1027 - (35%)	Gaps:	285/1027 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1293 DFTEVE-----HIKVEPP----PSY---AKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLH 1345
            ||.|.|     .|...||    ||.   |:||                       ...||:..|.
Human    75 DFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVF-----------------------TLSVPNISLP 116

  Fly  1346 MNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNEN 1410
            ..::..|....::.     :|.|.::..:..:|.|.||.|..|  :.:....|.| ..:|.:..:
Human   117 APSQFQPSVEGLKS-----QVARHSLNYIQEIGNGWFGKVLLG--EIYTGTSVAR-VIVKELKAS 173

  Fly  1411 ATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAM 1475
            |..:|:..||............::::.:|.|....|.|:|.|....||||:|||:.:...|.::.
Human   174 ANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQ 238

  Fly  1476 MTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGM 1540
            ...|.|                 ||.|:|.|:|.:....|:|.|||.|||.:..||.||:||:|:
Human   239 TMLLQR-----------------MACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGI 286

  Fly  1541 TRDIYETDYYRKGTKGLLPVRWMPPE---SLRDGVYSS----ASDVFSFGVVLWEMATLAAQPYQ 1598
            ....|:.||.....|.:.|:||..||   |.:|.:.::    .|:::|.||.|||:...|||||.
Human   287 GFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYS 351

  Fly  1599 GLSNEQVLRYVIDGGVMERPENCP---------DFLHKLMQRCWHHRSSARPSFLDI---IAYLE 1651
            .|||..||..||    .||....|         |..::::|.|| .....||:..|:   :.||.
Human   352 NLSNLDVLNQVI----RERDTKLPKPQLEQPYSDRWYEVLQFCW-LSPEKRPAAEDVHRLLTYLR 411

  Fly  1652 PQCPNSQFKEVSFYHSEAGLQHREKERKERNQ-----LDAFAAVPLDQDLQDREQQEDAT-TPLR 1710
            .|  :.:..||.|......|:.....|...|.     ||.||     :|...||.:|..| |...
Human   412 LQ--SQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFA-----RDRLGREMEEVLTVTETS 469

  Fly  1711 MG---DY-QQNSSLDQPPESPIAMVDDQGSHLPFSLPSGFIASSTPD-GQTVMATAFQNIPAAQG 1770
            .|   :| .:.:..|...|.....:|:..|:.....|.....||..| |......:.|::|
Human   470 QGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVP---- 530

  Fly  1771 DISATYVVP--DADALDGDRGYEI-------------YDPS-------------PKCAELPTSRS 1807
             :....|||  ||..|.....|.|             |.|:             |:.::|...||
Human   531 -LRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRS 594

  Fly  1808 --------------GSTG--GGKLSGEQHLLPRKGRQPTI--------MSSSMPD-----DVIGG 1843
                          .||.  ...|.|:.|:  ..|.:...        .|..:|.     |::..
Human   595 VELEESSTDEDFFQSSTDPKDSSLPGDLHV--TSGPESPFNNIFNDVDKSEDLPSHQKIFDLMEL 657

  Fly  1844 SSLQ----PSTASAGSSN-----ASSHTGRPSLKK-------TVADSVRNKANFINRHLFNHKRT 1892
            :.:|    |:|.|:...|     .:.|..:...:|       .::|::.::.||   ...|.:..
Human   658 NGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNF---DPLNVQEL 719

  Fly  1893 GSN--ASHKSNASNAPSTSSNTNLTSHPVAMGNLGTIESGGSGSAGSYTGTPRFYTPSATPGGGS 1955
            ..|  ...:.|.... |.||..::......:.|.|..|:....|..:...|.
Human   720 SENFLFLQEKNLLKG-SLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTE------------- 770

  Fly  1956 GMAISDN-PNYRLLDESIAS--EQATILTT---------SSPNPNYEMMHPPTSL-VSTNPNYMP 2007
             :..::| |...||.|::::  :...::.|         |||    |:..||||. ....|..:|
Human   771 -LQFAENKPGLSLLQENVSTKGDDTDVMLTGDTLSTSLQSSP----EVQVPPTSFETEETPRRVP 830

  Fly  2008 MNETPVQMAGVT-----------------ISHNPNYQPMQ-APLNAR------QSQSSSDEDNEQ 2048
            .:..|.|  |.|                 ||.:....|:: ...:||      :||.|..|..|.
Human   831 PDSLPTQ--GETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEET 893

  Fly  2049 ---EEDDEDEDDDV-----------------------DDEHVEHIKMERMPLSRPRQRALPSKTQ 2087
               .|.|....||:                       .::|..|.::|:...:......|.||..
Human   894 LRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDA 958

  Fly  2088 PPRSRSVSQTRKSPTNPNSGIGATGAGNRSNLLKENWLR--PASTPRPPPPN 2137
            ...:..||......|:.:|            ||:::...  |||.|....|:
Human   959 AKEAGLVSALSSDSTSQDS------------LLEDSLSAPFPASEPSLETPD 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_001138093.1	Recep_L_domain	356..465	CDD:279382
		Furin-like	512..645	CDD:279142
		FU	545..592	CDD:238021
		Recep_L_domain	663..781	CDD:279382
		FN3	1224..1302	CDD:238020	5/13 (38%)
		PTKc_InsR_like	1364..1652	CDD:173625	94/306 (31%)
		Pkinase_Tyr	1371..1650	CDD:285015	90/297 (30%)
LMTK2	NP_055731.2	Pkinase_Tyr	137..407	CDD:285015	90/294 (31%)
		PTKc_Aatyk2	139..409	CDD:270669	90/294 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..622		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	804..840		13/41 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	875..898		6/22 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	970..999		9/41 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1013..1202
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1276..1317
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1372..1469
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910