DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and Tyro3

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_062265.2 Gene:Tyro3 / 22174 MGIID:104294 Length:880 Species:Mus musculus


Alignment Length:591 Identity:163/591 - (27%)
Similarity:268/591 - (45%) Gaps:127/591 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1216 HANNTESPVRVRWTP--PVDP-NGEIVTYEVAYKLQKPDQVE---EKKCIPAADFNQTAGYLIKL 1274
            ||..|:|.:.:.|..  |.|| .|.:..|::::..:...|.|   |.......|::.....::  
Mouse   320 HAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTRANLTDWDPQKDLIL-- 382

  Fly  1275 NEGLYSFRVRANSIAGYGDFTEV------EHIKVEPPP----SYAKVFFWLLGIGLAFLIVSLFG 1329
                   ||.|::..|.|.:::.      :|...:.||    |:..|   :||:..|.:..:...
Mouse   383 -------RVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTSWVPV---VLGVLTALITAAALA 437

  Fly  1330 YVCYLHKRKVP------SNDLHMNTEVNPFYASMQY----------------IPDDWEVLRENII 1372
            .:....:||..      .:.:........|.|:..:                |.|:.:...|:: 
Mouse   438 LILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDV- 501

  Fly  1373 QLAP---------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNEN---ATDRERTNFLSEASV 1425
             |.|         ||:|.||.|.|..||.  .:|...:.|:|.:..:   ::|.|  .||.||:.
Mouse   502 -LIPEQQFTLGRMLGKGEFGSVREAQLKQ--EDGSFVKVAVKMLKADIIASSDIE--EFLREAAC 561

  Fly  1426 MKEFDTYHVVRLLGVCSRGQP------ALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGV 1484
            |||||..||.:|:||..|.:.      .:|::..||.|||.::|.|              :|||.
Mouse   562 MKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLA--------------SRIGE 612

  Fly  1485 TG-NVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD 1548
            .. |:...|   :.:..::||.||.||:::.|:||||||||||:|:|:||.:.|||::|.||..|
Mouse   613 NPFNLPLQT---LVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGD 674

  Fly  1549 YYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGG 1613
            |||:|....|||:|:..|||.|.:|:..|||::|||.:||:.|....||.|:.|.::..|:|.|.
Mouse   675 YYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGN 739

  Fly  1614 VMERPENCPDFLHKLMQRCWHHRSSARPSFL-------DIIAYL-------EPQCPNSQFKEVSF 1664
            .:::|..|.:.::.||.:||......||||.       :|:.:|       :|...|.:..|   
Mouse   740 RLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIERAE--- 801

  Fly  1665 YHSEAGL------QHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQN-SSLDQ 1722
            ..:|:|.      :....|..:.:.:.|...:|           .|:......|...:: ..|:|
Mouse   802 QPTESGSPEVHCGERSSSEAGDGSGVGAVGGIP-----------SDSRYIFSPGGLSESPGQLEQ 855

  Fly  1723 PPESPI 1728
            .||||:
Mouse   856 QPESPL 861

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 16/89 (18%)
PTKc_InsR_like 1364..1652 CDD:173625 114/320 (36%)
Tyro3NP_062265.2 Ig 40..126 CDD:472250
Ig strand B 50..54 CDD:409553
Ig strand C 63..67 CDD:409553
Ig strand E 90..94 CDD:409553
Ig strand F 104..109 CDD:409553
Ig strand G 118..121 CDD:409553
Ig 130..209 CDD:472250
Ig strand B 146..150 CDD:409407
Ig strand C 160..164 CDD:409407
Ig strand E 178..182 CDD:409407
Ig strand F 190..195 CDD:409407
Ig strand G 204..207 CDD:409407
FN3 215..307 CDD:238020
fn3 315..396 CDD:394996 19/84 (23%)
PTKc_Tyro3 498..781 CDD:270659 113/305 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..864 14/76 (18%)
Blue background indicates that the domain is not in the aligned region.

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