Protein Alignment InR and Tek

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_038718.2
• Gene: Tek / 21687
• MGIID: 98664
• Length: 1123
• Species: Mus musculus
• Alignment Length: 1499
• Identity: 309/1499 - (20%)
• Similarity: 503/1499 - (33%)
• Gaps: 512/1499 - (34%)

  Fly   271 GISLLLF--------ILLANTL-----AIQAVVLPAHQQHLLHNDIADGLDKTA--------LSV 314
            |:||||:        ::|.|:|     |..::...|...| .|..|..|.|..|        |.|
Mouse    11 GVSLLLYGVVEGAMDLILINSLPLVSDAETSLTCIASGWH-PHEPITIGRDFEALMNQHQDPLEV 74

  Fly   315 SGTQSR-------WTRSESNPTM-------RLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLL 365
            :...:|       |.|.:::...       |:.......::|.:|...|........||..|
Mouse    75 TQDVTREWAKKVVWKREKASKINGAYFCEGRVRGQAIRIRTMKMRQQASFLPATLTMTVDRG--- 136

  Fly   366 IDLINDASPLNRSFPK-LTEVTDYIIIYRVTGLHSLSK-IFPNLSVIRGNKLFDGYALVVYSNFD 428
                   ..:|.||.| |.:..|.:|....:.:||:.: ..|::..:.            ..:..
Mouse   137 -------DNVNISFKKVLIKEEDAVIYKNGSFIHSVPRHEVPDILEVH------------LPHAQ 182

  Fly   429 LMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVVLTENGKEKECRLSKCPGEI 493
            ..|.|::..|.|  ||                  .:.....|:|:|       :.|...|
Mouse   183 PQDAGVYSARYI--GG------------------NLFTSAFTRLIV-------RRCEAQK----- 215

  Fly   494 RIEEGHDTTAIEGELNASCQLHNNRRLCWN---SKLCQTKCPEKCRNNCIDEHTCCSQDCLGGCV 555
                                        |.   |:.|.|     |:||.:     |.:| .|.|:
Mouse   216 ----------------------------WGPDCSRPCTT-----CKNNGV-----CHED-TGECI 241

  Fly   556 IDKN--GNESCISCRNVSFNNICMDSC--PKGYYQFDSRCVTANECITLTKFETNSVYSGIPYNG 616
            ....  |.....:|...:|...|.:.|  |:|       |.:...|:.            .||..
Mouse   242 CPPGFMGRTCEKACEPHTFGRTCKERCSGPEG-------CKSYVFCLP------------DPYGC 287

  Fly   617 QCIT---------HCPTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLERAREFHGCTIITGTEP 672
            .|.|         .||:||...:.|..|.......||:               |.||....|.:.
Mouse   288 SCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDR---------------FQGCLCSQGWQG 337

  Fly   673 LTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALY 737
            |  ..::|....:..:::           .|..|:.  :.|.| |..:.:.||.|...:::..|.
Mouse   338 L--QCEKEGRPRMTPQIE-----------DLPDHIE--VNSGK-FNPICKASGWPLPTSEEMTLV 386

  Fly   738 VLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVS--TINQLLPMLASKPKFFEKSDVGADSNGN 800
            ..|...|.    ||.          |::..:..|:  |:|::||         ..|.|...|...
Mouse   387 KPDGTVLQ----PND----------FNYTDRFSVAIFTVNRVLP---------PDSGVWVCSVNT 428

  Fly   801 RGSCGTAVLNVTLQ------------SVGANSAMLNVTTKVEIGE-PQKPSNATIVFKDPRAFIG 852
            .........|::::            ..|.|.|::|::::...|: |.|...
Mouse   429 VAGMVEKPFNISVKVLPEPLHAPNVIDTGHNFAIINISSEPYFGDGPIKSKK------------- 480

  Fly   853 FVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAES 917
             :||              .|.:..||....... :..|:.|.|.|:|...|: :|...|
Mouse   481 -LFY--------------KPVNQAWKYIEVTNE-IFTLNYLEPRTDYELCVQ-LARPGE------ 522

  Fly   918 DVKNFRTNPGRPSKVTEVVATAI-------------SDSKINVTWSYLDKPYGVLTRYFIKAKLI 969
                  ...|.|..|......:|             |.:.:|:||
Mouse   523 ------GGEGHPGPVRRFTTASIGLPPPRGLSLLPKSQTALNLTW-------------------- 561

  Fly   970 NRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGME 1034
             :|...|:.|   |..|:.....|..|:..:.|..|  |:...|..|.....::|..|
Mouse   562 -QPIFTNSED---EFYVEVERRSLQTTSDQQNIKVP--GNLTSVLLSNLVPREQYTVR------- 613

  Fly  1035 FENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGS 1099
                         .|.:.....:.|:......| |:.:|                 |:.::::
Mouse   614 -------------ARVNTKAQGEWSEELRAWTL-SDILP-----------------PQPENIK-- 645

  Fly  1100 VLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLRH--FTRY 1162
                 :.:|||.|...     ..|..|...:||....|:|..|    |:...:..|:::  .|:|
Mouse   646 -----ISNITDSTAMV-----SWTIVDGYSISSIIIRYKVQGK----NEDQHIDVKIKNATVTQY 696

  Fly  1163 AIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVR 1227
            .:                    |.|  :.:|.:.               ||:...||..|
Mouse   697 QL--------------------KGL--EPETTYH---------------VDIFAENNIGS----- 719

  Fly  1228 WTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIP----AADFNQTAGYLIKLNEGLYSFRVRANSI 1288
                                ..|....|.:.:|    :||.......||              :|
Mouse   720 --------------------SNPAFSHELRTLPHSPASADLGGGKMLLI--------------AI 750

  Fly  1289 AGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYV--------CYLHKRKVP----- 1340
            .|....|                   .:.:.|||||:......        .:.:.|:.|
Mouse   751 LGSAGMT-------------------CITVLLAFLIMLQLKRANVQRRMAQAFQNVREEPAVQFN 796

  Fly  1341 SNDLHMNTEV--NPFYASMQYIPDDWEVLRENIIQLAP-LGQGSFGMVYEGILKSFPPNGVDREC 1402
            |..|.:|.:.  ||       .|..:.||..|.|:... :|:|:||.|.:..:|.   :|:..:.
Mouse   797 SGTLALNRKAKNNP-------DPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKK---DGLRMDA 851

  Fly  1403 AIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAH 1466
            |||.:.|.|:..:..:|..|..|:.:...: :::.|||.|.......:.:|....|:|..:||..
Mouse   852 AIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKS 916

  Fly  1467 RPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDL 1531
            |..|.|.| ....|....|.:.|     ::...|.::|.||.||:.|:|:||||||||.:|.::.
Mouse   917 RVLETDPA-FAIANSTASTLSSQ-----QLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENY 975

  Fly  1532 TVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQP 1596
            ..||.|||::|.   .:.|.|.|.|.||||||..|||...||::.|||:|:||:|||:.:|...|
Mouse   976 IAKIADFGLSRG---QEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTP 1037

  Fly  1597 YQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKE 1661
            |.|::..::...:..|..:|:|.||.|.::.||::||..:...||||..|:..|     |...:|
Mouse  1038 YCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL-----NRMLEE 1097

  Fly  1662 VSFY 1665
            ...|
Mouse  1098 RKTY 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	19/110 (17%)
		Furin-like	510..645	CDD:395614	31/150 (21%)
		Recep_L_domain	663..781	CDD:460032	24/119 (20%)
		FN3	791..>964	CDD:442628	32/198 (16%)
		FN3	1224..1302	CDD:238020	10/81 (12%)
		PTKc_InsR_like	1364..1652	CDD:173625	102/289 (35%)
Tek	NP_038718.2	Ig_Tie2_1	24..118	CDD:463089	18/94 (19%)
		EGF_Lam	230..275	CDD:238012	12/57 (21%)
		IgI_Tie2	348..439	CDD:409556	22/127 (17%)
		Ig strand A	348..352	CDD:409556	0/3 (0%)
		Ig strand A'	358..362	CDD:409556	1/5 (20%)
		Ig strand B	365..374	CDD:409556	2/9 (22%)
		Ig strand C	382..387	CDD:409556	1/4 (25%)
		Ig strand C'	391..393	CDD:409556	0/1 (0%)
		Ig strand D	397..401	CDD:409556	1/13 (8%)
		Ig strand E	404..412	CDD:409556	2/7 (29%)
		Ig strand F	420..428	CDD:409556	2/7 (29%)
		Ig strand G	431..439	CDD:409556	0/7 (0%)
		fn3	445..516	CDD:394996	17/99 (17%)
		fn3	542..625	CDD:394996	19/128 (15%)
		FN3	638..730	CDD:238020	27/186 (15%)
		PTKc_Tie2	815..1117	CDD:133219	105/304 (35%)