Protein Alignment InR and EPHB3

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_004434.2
• Gene: EPHB3 / 2049
• HGNCID: 3394
• Length: 998
• Species: Homo sapiens
• Alignment Length: 803
• Identity: 206/803 - (25%)
• Similarity: 322/803 - (40%)
• Gaps: 208/803 - (25%)

  Fly  1008 GDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAI 1072
            |.|.|..| .:.:::|...|...               |...|:|.|        ||..|.  ..
Human   267 GACTCATG-HEPAAKESQCRPCP---------------PGSYKAKQG--------EGPCLP--CP 305

  Fly  1073 PNGGATNPSRR---------RRDVALEPELDDVEGSVLL-----RHVRSITDDTDAFFEKDDENT 1123
            ||...|:|:..         |.|      .|..:.:...     |.|.|..::|....|..:...
Human   306 PNSRTTSPAASICTCHNNFYRAD------SDSADSACTTVPSPPRGVISNVNETSLILEWSEPRD 364

  Fly  1124 YKDEEDLSSNKQFYEVFAK------------------ELPPNQ-------THFVFEKLRHFTRYA 1163
            ....:||     .|.|..|                  |..|.|       .| :...|.| |||.
Human   365 LGGRDDL-----LYNVICKKCHGAGGASACSRCDDNVEFVPRQLGLTERRVH-ISHLLAH-TRYT 422

  Fly  1164 IFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRW 1228
            ..|.|         :...|.|..|...|..|..||.:...:::     ..|...:::.|.:.:.|
Human   423 FEVQA---------VNGVSGKSPLPPRYAAVNITTNQAAPSEV-----PTLRLHSSSGSSLTLSW 473

  Fly  1229 TPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL-----YSFRVRANSI 1288
            .||..|||.|:.||:.|       .|:.:.|.:...:|.....:   :||     |..:|||.::
Human   474 APPERPNGVILDYEMKY-------FEKSEGIASTVTSQMNSVQL---DGLRPDARYVVQVRARTV 528

  Fly  1289 AGYGDFTE-------------VEHIKVEPPPSYAKVFFWLLG---IGLAFLI-VSLFGYVCYLHK 1336
            ||||.::.             .:.::.:.|        .::|   .||.|:: |.:...|| |.|
Human   529 AGYGQYSRPAEFETTSERGSGAQQLQEQLP--------LIVGSATAGLVFVVAVVVIAIVC-LRK 584

  Fly  1337 RKVPSNDLH-----------MNTEVNPFYASMQYIPDDWEVLRE-------NIIQLAP-LGQGSF 1382
            ::..|:..:           |...::||     ...|..|.:||       :.:::.. :|.|.|
Human   585 QRHGSDSEYTEKLQQYIAPGMKVYIDPF-----TYEDPNEAVREFAKEIDVSCVKIEEVIGAGEF 644

  Fly  1383 GMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPA 1447
            |.|..|.||.  |...:...||||:....|:|:|.:||||||:|.:||..:::||.||.::.:|.
Human   645 GEVCRGRLKQ--PGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPV 707

  Fly  1448 LVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAA 1512
            :::.|.|:...|.|:||.      ::...|.:..:|               |...||.||.||:.
Human   708 MILTEFMENCALDSFLRL------NDGQFTVIQLVG---------------MLRGIAAGMKYLSE 751

  Fly  1513 KKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD----YYRKGTKGLLPVRWMPPESLRDGVY 1573
            ..:|||||||||.:|..:|..|:.|||::| ..|.|    .|.....|.:|:||..||::....:
Human   752 MNYVHRDLAARNILVNSNLVCKVSDFGLSR-FLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKF 815

  Fly  1574 SSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSS 1638
            :|||||:|:|:|:||:.:...:||..:||:.|:..|.....:..|.:||..||:||..||....:
Human   816 TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRN 880

  Fly  1639 ARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQE 1703
            .||.|..|:..|:....|:...:|.                      |.|...:.|.|.|| ...
Human   881 LRPKFSQIVNTLDKLIRNAASLKVI----------------------ASAQSGMSQPLLDR-TVP 922

  Fly  1704 DATTPLRMGDYQQNSSLDQPPES 1726
            |.||...:||:.....:.:..||
Human   923 DYTTFTTVGDWLDAIKMGRYKES 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	23/95 (24%)
		PTKc_InsR_like	1364..1652	CDD:173625	103/299 (34%)
EPHB3	NP_004434.2	EphR_LBD_B3	39..211	CDD:198446
		Ephrin_rec_like	272..316	CDD:429604	14/69 (20%)
		fn3	341..436	CDD:394996	23/110 (21%)
		FN3	<473..542	CDD:238020	23/78 (29%)
		EphA2_TM	560..630	CDD:464211	17/75 (23%)
		PTKc_EphR_B	628..896	CDD:173638	100/291 (34%)
		SAM_superfamily	922..990	CDD:472832	7/24 (29%)