DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and EPHA8

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_065387.1 Gene:EPHA8 / 2046 HGNCID:3391 Length:1005 Species:Homo sapiens


Alignment Length:883 Identity:223/883 - (25%)
Similarity:336/883 - (38%) Gaps:262/883 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   889 VLSNLIPYTNYSYYVRTMAISSE-LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYL 952
            :||..|.|......||.:|..|| :|.|:|            |.:.||....:..|:        
Human   194 ILSLRIYYKKCPAMVRNLAAFSEAVTGADS------------SSLVEVRGQCVRHSE-------- 238

  Fly   953 DKPYGVLTRYFIKAKLINRPTRNNNRDYCT---EPLVKAMENDLPATTPTKKISDPLAGDCKCVE 1014
                                .|:..:.||:   |.||                  |: |.|.|..
Human   239 --------------------ERDTPKMYCSAEGEWLV------------------PI-GKCVCSA 264

  Fly  1015 GSKKTSSQEYDDRK---VQAGMEFENALQNFIFVPNIRKSKNG----------SSDKSDGAEG-- 1064
            |        |::|:   |...:.|             .||..|          |...:..|:.  
Human   265 G--------YEERRDACVACELGF-------------YKSAPGDQLCARCPPHSHSAAPAAQACH 308

  Fly  1065 -------AALDSNAIPNGGATNP---------SRRRRDVALE--PELD-----DVEGSVLLRHVR 1106
                   ||||.   |:...|.|         |.....|.||  |.||     |:..:.:.|...
Human   309 CDLSYYRAALDP---PSSACTRPPSAPVNLISSVNGTSVTLEWAPPLDPGGRSDITYNAVCRRCP 370

  Fly  1107 SITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTH------FVFEKLRHFTRYAIF 1165
            ......:|               ..|..:|.        |.||.      .|...|.|. .|:.:
Human   371 WALSRCEA---------------CGSGTRFV--------PQQTSLVQASLLVANLLAHM-NYSFW 411

  Fly  1166 VVACR--EEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRW 1228
            :.|..  .::..|..|..           .|..||.:...:.:|:   :..|.|..|.  |.:.|
Human   412 IEAVNGVSDLSPEPRRAA-----------VVNITTNQAAPSQVVV---IRQERAGQTS--VSLLW 460

  Fly  1229 TPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL-YSFRVRANSIAGYG 1292
            ..|..|||.|:.||:.| .:|..:::....:.|.....|..   .|..|. |.|:|||.:.||.|
Human   461 QEPEQPNGIILEYEIKY-YEKDKEMQSYSTLKAVTTRATVS---GLKPGTRYVFQVRARTSAGCG 521

  Fly  1293 DFTEVEHIKV-EPPPSY-AKVFFWLLGIGLAFLIVSLFGYVCYL----HKRKVPSND---LH-MN 1347
            .|::...::. :|.|.| .:...|:....:..|:|.|...:|..    :.:....:|   :| .|
Human   522 RFSQAMEVETGKPRPRYDTRTIVWICLTLITGLVVLLLLLICKKRHCGYSKAFQDSDEEKMHYQN 586

  Fly  1348 TEVNP-----------------FYASMQYIPD----------DWEVLRENIIQLAPLGQGSFGMV 1385
            .:..|                 |||......:          :.|..|.:|.::  :|.|..|.|
Human   587 GQAPPPVFLPLHHPPGKLPEPQFYAEPHTYEEPGRAGRSFTREIEASRIHIEKI--IGSGDSGEV 649

  Fly  1386 YEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVV 1450
            ..|.|:  .|...|...|||.:....|:|:|.:||||||:|.:||..:::||.||.:||:.|::|
Human   650 CYGRLR--VPGQRDVPVAIKALKAGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTRGRLAMIV 712

  Fly  1451 MELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKF 1515
            .|.|:.|.|.::||.|      :...|.:..:|               |...:..||.||:...:
Human   713 TEYMENGSLDTFLRTH------DGQFTIMQLVG---------------MLRGVGAGMRYLSDLGY 756

  Fly  1516 VHRDLAARNCMVADDLTVKIGDFGMTRDIYETD----YYRKGTKGLLPVRWMPPESLRDGVYSSA 1576
            |||||||||.:|..:|..|:.|||::| :.|.|    |...|  |.:|:||..||::....:|||
Human   757 VHRDLAARNVLVDSNLVCKVSDFGLSR-VLEDDPDAAYTTTG--GKIPIRWTAPEAIAFRTFSSA 818

  Fly  1577 SDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARP 1641
            |||:|||||:||:.....:||..::|..|:..|.:|..:..|..||..||:||..|||...:.||
Human   819 SDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRP 883

  Fly  1642 SFLDIIAYLE---------------PQCPNSQFKEVSF 1664
            .|..|::.|:               .:||...|....|
Human   884 RFSQIVSVLDALIRSPESLRATATVSRCPPPAFVRSCF 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 16/75 (21%)
FN3 1224..1302 CDD:238020 24/78 (31%)
PTKc_InsR_like 1364..1652 CDD:173625 108/306 (35%)
EPHA8NP_065387.1 EphR_LBD 31..203 CDD:470656 4/8 (50%)
FN3 <326..>519 CDD:442628 51/236 (22%)
fn3 439..524 CDD:394996 27/93 (29%)
EphA2_TM <562..632 CDD:464211 8/69 (12%)
Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000250 564..570 0/5 (0%)
Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000250 589..644 8/56 (14%)
PTKc_EphR_A 630..896 CDD:270651 108/293 (37%)
SAM_EPH-A8 933..995 CDD:188949
PDZ-binding. /evidence=ECO:0000255 1003..1005
Blue background indicates that the domain is not in the aligned region.

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