Protein Alignment InR and EPHA7

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_004431.1
• Gene: EPHA7 / 2045
• HGNCID: 3390
• Length: 998
• Species: Homo sapiens
• Alignment Length: 1016
• Identity: 244/1016 - (24%)
• Similarity: 387/1016 - (38%)
• Gaps: 303/1016 - (29%)

  Fly   750 PNQ-----TVFIRKGG---VFFHFNPKLCVSTINQLLPMLASKPKFFE------KSDVGADSNGN 800
            |||     |.:|.||.   :|...  |..:...|.|..:|.:..:.|.      ..|.|.:...|
Human    79 PNQNNWLRTNWISKGNAQRIFVEL--KFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIREN 141

  Fly   801 RGSCGTAVLNVTLQSVGANSAM---------LNVTTKV-EIGEPQKPSNATIVFKDPRAFIGFVF 855
                    |.|.:.::.|:.:.         :.:.|:| ||| |.......:.|:|..|.|..|
Human   142 --------LYVKIDTIAADESFTQGDLGERKMKLNTEVREIG-PLSKKGFYLAFQDVGACIALV- 196

  Fly   856 YHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSE-LTNAESDV 919
                     |.|.....|   |.:                       :..:||..: :|.:|.
Human   197 ---------SVKVYYKKC---WSI-----------------------IENLAIFPDTVTGSEF-- 224

  Fly   920 KNFRTNPGRPSKVTEVVATAISDSKINV------------TWSYLDKPYGVLTRYFIKAKLINRP 972
                      |.:.||..|.:|.::...            .|..   |.|         |.|.:.
Human   225 ----------SSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLV---PIG---------KCICKA 267

  Fly   973 TRNNNRDYCTEP----LVKAMENDLPAT-TPTKKISDPLAGD-CKCVEGSKKTSSQEYDDRKVQA 1031
            ......|.| ||    ..|:...||..: .||...||..... |:|.:|..:..|    |....|
Human   268 GYQQKGDTC-EPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPS----DPPYVA 327

  Fly  1032 GMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRR---RR-------- 1085
            .....:|.||.||  ||.:: ..|.:.|..|:          |||..:.:.|   :|
Human   328 CTRPPSAPQNLIF--NINQT-TVSLEWSPPAD----------NGGRNDVTYRILCKRCSWEQGEC 379

  Fly  1086 -----DVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFY---EVFAK 1142
                 ::...|:...:|.:.:.  |..:....:..||.:..|   ...|||.:::.:   .:...
Human   380 VPCGSNIGYMPQQTGLEDNYVT--VMDLLAHANYTFEVEAVN---GVSDLSRSQRLFAAVSITTG 439

  Fly  1143 ELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIV 1207
            :..|:|...|.:                                     :.|.|.:
Human   440 QAAPSQVSGVMK-------------------------------------ERVLQRS--------- 458

  Fly  1208 MDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLI 1272
                            |.:.|..|..|||.|..||:.|  .:.||.|  :.........|:..:.
Human   459 ----------------VELSWQEPEHPNGVITEYEIKY--YEKDQRE--RTYSTVKTKSTSASIN 503

  Fly  1273 KLNEG-LYSFRVRANSIAGYGDFT----------------EVEHIKVEPPPSYAKVFFWLLGI-G 1319
            .|..| :|.|::||.:.||||:::                |...:..|..|   .:...::.: |
Human   504 NLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNP---VIIIAVVAVAG 565

  Fly  1320 LAFLIVSLFGYV-----C-YLHKRKVPSNDLHMNTEVNPFYASMQYI-PDDWEVLRENIIQLAP- 1376
            ...|:..:||::     | |....:....:|:.:.:   |..:..|| |:.:|.....:.|.|.
Human   566 TIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFK---FPGTKTYIDPETYEDPNRAVHQFAKE 627

  Fly  1377 -----------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFD 1430
                       :|.|.||.|..|.||.  |...|...||||:....|:::|.:||.|||:|.:||
Human   628 LDASCIKIERVIGAGEFGEVCSGRLKL--PGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFD 690

  Fly  1431 TYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGR 1495
            ..:||.|.||.:||:|.::|:|.|:.|.|.::||.|      :...|.:..:|
Human   691 HPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKH------DGQFTVIQLVG------------ 737

  Fly  1496 IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR-------DIYETDYYRKG 1553
               |...||.||.|||...:|||||||||.:|..:|..|:.|||::|       .:|.|
Human   738 ---MLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTT------ 793

  Fly  1554 TKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERP 1618
            |.|.:||||..||:::...::|||||:|:|:|:||:.:...:||..:||:.|::.:.:|..:..|
Human   794 TGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAP 858

  Fly  1619 ENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQC--PNS 1657
            .:||..||:||..||....:.||.|..|:..|:...  |||
Human   859 MDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNS 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032	11/38 (29%)
		FN3	791..>964	CDD:442628	33/195 (17%)
		FN3	1224..1302	CDD:238020	25/94 (27%)
		PTKc_InsR_like	1364..1652	CDD:173625	109/306 (36%)
EPHA7	NP_004431.1	EphR_LBD_A7	30..206	CDD:198453	33/150 (22%)
		FN3	<314..>539	CDD:442628	57/312 (18%)
		FN3	443..534	CDD:238020	29/156 (19%)
		EphA2_TM	565..630	CDD:464211	14/67 (21%)
		PTKc_EphR_A	628..894	CDD:270651	106/294 (36%)
		SAM_EPH-A7	919..988	CDD:188947
		PDZ-binding. /evidence=ECO:0000255	996..998