DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and EPHA5

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001268694.1 Gene:EPHA5 / 2044 HGNCID:3389 Length:1038 Species:Homo sapiens


Alignment Length:611 Identity:160/611 - (26%)
Similarity:266/611 - (43%) Gaps:133/611 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1132 SNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACR---------EE-------IPSEK-LR 1179
            ||.....||.:.:||..|        ...:...:.:||:         ||       :|.:. |:
Human   366 SNVNETSVFLEWIPPADT--------GGRKDVSYYIACKKCNSHAGVCEECGGHVRYLPRQSGLK 422

  Fly  1180 DTS-FKKSLCSDYDTVFQTTKRKKFADIVMDLK--VDLEHANNTESP---------------VRV 1226
            :|| ....|.:..:..|:.......:|:....:  |.:....|..:|               :.:
Human   423 NTSVMMVDLLAHTNYTFEIEAVNGVSDLSPGARQYVSVNVTTNQAAPSPVTNVKKGKIAKNSISL 487

  Fly  1227 RWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL-----YSFRVRAN 1286
            .|..|..|||.|:.||:.| .:| ||......|.:.:...||       |||     |.|::||.
Human   488 SWQEPDRPNGIILEYEIKY-FEK-DQETSYTIIKSKETTITA-------EGLKPASVYVFQIRAR 543

  Fly  1287 SIAGYGDFTEVEHIKVEP-------PPSYAKVFFWLLGIGLAFLI----VSLFGYVC-------- 1332
            :.||||.|:.....:..|       ..|...|....:.:|:..|.    |.|.|..|        
Human   544 TAAGYGVFSRRFEFETTPVSVAASSDQSQIPVIAVSVTVGVILLAVVIGVLLSGSCCECGCGRAS 608

  Fly  1333 ---------------YLHKRKVPSND-LHMNTEVNPFYASMQYI-PDDWEVLRENIIQLAP---- 1376
                           |...::.|..: :|.:...........|| |..:|...:.:.:.|.    
Human   609 SLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAKEIEA 673

  Fly  1377 --------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYH 1433
                    :|.|.||.|..|.||.  |...:...||||:....|:::|.:||.|||:|.:||..:
Human   674 SCITIERVIGAGEFGEVCSGRLKL--PGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPN 736

  Fly  1434 VVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQ 1498
            ::.|.||.::.:|.::|.|.|:.|.|.::|:      :::...|.:..:|               
Human   737 IIHLEGVVTKSKPVMIVTEYMENGSLDTFLK------KNDGQFTVIQLVG--------------- 780

  Fly  1499 MAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---DIYETDYYRKGTKGLLPV 1560
            |...|:.||.||:...:|||||||||.::..:|..|:.|||::|   |..|..|..:|  |.:|:
Human   781 MLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG--GKIPI 843

  Fly  1561 RWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFL 1625
            ||..||::....::|||||:|:|:|:||:.:...:||..::|:.|::.|.:|..:..|.:||..|
Human   844 RWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAAL 908

  Fly  1626 HKLMQRCWHHRSSARPSFLDIIAYLE 1651
            ::||..||....::||.|.:|:..|:
Human   909 YQLMLDCWQKERNSRPKFDEIVNMLD 934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 27/82 (33%)
PTKc_InsR_like 1364..1652 CDD:173625 97/303 (32%)
EPHA5NP_001268694.1 EphR_LBD_A5 60..232 CDD:198451
FN3 <355..>598 CDD:442628 55/248 (22%)
FN3 469..559 CDD:238020 28/98 (29%)
EphA2_TM 576..673 CDD:464211 14/96 (15%)
PTKc_EphR_A 671..937 CDD:270651 95/289 (33%)
SAM_EPH-A5 966..1031 CDD:188945
Blue background indicates that the domain is not in the aligned region.

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